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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1947 2
1949 3
1951 2
1952 3
1953 8
1954 6
1955 6
1956 4
1957 4
1958 7
1959 9
1960 21
1961 15
1962 10
1963 18
1964 21
1965 14
1966 22
1967 30
1968 48
1969 38
1970 46
1971 54
1972 68
1973 74
1974 86
1975 79
1976 76
1977 68
1978 47
1979 68
1980 75
1981 69
1982 67
1983 66
1984 93
1985 78
1986 95
1987 85
1988 88
1989 99
1990 91
1991 117
1992 93
1993 82
1994 99
1995 106
1996 82
1997 87
1998 107
1999 119
2000 167
2001 139
2002 151
2003 175
2004 202
2005 183
2006 198
2007 183
2008 192
2009 178
2010 163
2011 186
2012 197
2013 192
2014 201
2015 159
2016 164
2017 157
2018 153
2019 168
2020 152
2021 151
2022 117
2023 108
2024 51

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6,540 results

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Page 1
The kinetic isotope effect in the search for deuterated drugs.
Shao L, Hewitt MC. Shao L, et al. Drug News Perspect. 2010 Jul-Aug;23(6):398-404. doi: 10.1358/dnp.2010.23.6.1426638. Drug News Perspect. 2010. PMID: 20697607 Free article. Review.
The kinetic isotope effect has long been exploited by physical organic chemists to study reaction mechanisms due to its effect on reaction rates when cleavage of a C-isotope bond is rate determining. ...A history of the deuterium kinetic isot …
The kinetic isotope effect has long been exploited by physical organic chemists to study reaction mechanisms due to its eff …
Partially-deuterated samples of HET-s(218-289) fibrils: assignment and deuterium isotope effect.
Smith AA, Ravotti F, Testori E, Cadalbert R, Ernst M, Böckmann A, Meier BH. Smith AA, et al. J Biomol NMR. 2017 Feb;67(2):109-119. doi: 10.1007/s10858-016-0087-0. Epub 2017 Jan 10. J Biomol NMR. 2017. PMID: 28074361
The samples used are partially deuterated for higher spectral resolution, and the shifts in resonance frequencies of Calpha and Cbeta due to the deuterium isotope effect are investigated. It is shown that the deuterium isotope effect can …
The samples used are partially deuterated for higher spectral resolution, and the shifts in resonance frequencies of Calpha and Cbeta due to …
Synthesis of Deuterium-Labeled Pyrrolylcarnosine.
Shevchenko VP, Nagaev IY, Fedorova TN, Myasoedov NF. Shevchenko VP, et al. Dokl Biochem Biophys. 2022 Dec;507(1):374-379. doi: 10.1134/S1607672922340130. Epub 2023 Feb 14. Dokl Biochem Biophys. 2022. PMID: 36787006
The effect of temperature on the effectiveness of the incorporation of deuterium into pyrrolylcarnosine (PC) was studied. Deuterium gas and heavy water were used as a source of deuterium. Isotope exchange was carried out using solid-phase …
The effect of temperature on the effectiveness of the incorporation of deuterium into pyrrolylcarnosine (PC) was studie …
Deuterium isotope effects on noncovalent interactions between molecules.
Wade D. Wade D. Chem Biol Interact. 1999 Feb 12;117(3):191-217. doi: 10.1016/s0009-2797(98)00097-0. Chem Biol Interact. 1999. PMID: 10190576 Review.
The topic of deuterium isotope effects is usually concerned with the effects on chemical reactions that are caused by the substitution of deuterium atoms for protium, or hydrogen, atoms in a molecule. ...Deuterium isotope effect …
The topic of deuterium isotope effects is usually concerned with the effects on chemical reactions that are caus …
Kinetic deuterium isotope effects in cytochrome P450 oxidation reactions.
Guengerich FP. Guengerich FP. J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):428-31. doi: 10.1002/jlcr.3031. Epub 2013 Mar 10. J Labelled Comp Radiopharm. 2013. PMID: 24285515 Free PMC article. Review.
The rate-limiting nature of this step can be analyzed using the kinetic isotope effect (KIE) approach. The most relevant type of KIE is one termed intermolecular non-competitive, indicative of rate-limiting C-H bond breaking. A plot of KIE versus kcat for several P4 …
The rate-limiting nature of this step can be analyzed using the kinetic isotope effect (KIE) approach. The most relevant type …
Isotope effect studies on the cytochrome P450 enzymes.
Korzekwa KR, Gillette JR, Trager WF. Korzekwa KR, et al. Drug Metab Rev. 1995;27(1-2):45-59. doi: 10.3109/03602539509029814. Drug Metab Rev. 1995. PMID: 7641584 Review.
Isotope effect experiments provide a powerful tool for study of the fundamental aspects of the enzymology of the cytochrome P450 enzymes. ...Indeed, the kind of knowledge that isotope effect studies can provide is not readily obtainable by other method …
Isotope effect experiments provide a powerful tool for study of the fundamental aspects of the enzymology of the cytochrome P4 …
Employing deuterium kinetic isotope effects to uncover the mechanism of (R)-3-hydroxybutyrate dehydrogenase.
Machado TFG, da Silva RG. Machado TFG, et al. Methods Enzymol. 2023;685:225-240. doi: 10.1016/bs.mie.2023.03.004. Epub 2023 Apr 5. Methods Enzymol. 2023. PMID: 37245903
For the latter, however, one needs to determine the intrinsic isotope effect: that which would be measured if hydride transfer were rate determining. Alas, as is the case for many other enzymatic reactions, those catalyzed by SDRs are often limited by the rate of …
For the latter, however, one needs to determine the intrinsic isotope effect: that which would be measured if hydride transfer …
Deuterium isotope probing (DIP) on Listeria innocua: Optimisation of labelling and impact on viability state.
Trigueros S, Brauge T, Dedole T, Debuiche S, Rebuffel V, Morales S, Marcoux PR, Midelet G. Trigueros S, et al. PLoS One. 2023 Mar 9;18(3):e0280885. doi: 10.1371/journal.pone.0280885. eCollection 2023. PLoS One. 2023. PMID: 36893178 Free PMC article.
An innovative approach, Raman microspectroscopy coupled with deuterium isotope probing (Raman-DIP), can be used to evaluate the metabolism of deuterated carbon source in bacteria and also to presume different anabolic pathways. This method requires the treatment of …
An innovative approach, Raman microspectroscopy coupled with deuterium isotope probing (Raman-DIP), can be used to evaluate th …
Deuterium and its impact on living organisms.
Kselíková V, Vítová M, Bišová K. Kselíková V, et al. Folia Microbiol (Praha). 2019 Sep;64(5):673-681. doi: 10.1007/s12223-019-00740-0. Epub 2019 Jul 27. Folia Microbiol (Praha). 2019. PMID: 31352668 Review.
The rare stable isotope of hydrogen, deuterium, has fascinated researchers since its discovery in the 1930s. ...Deuterium exhibits unique physicochemical properties as well as having the strongest kinetic isotope effects among all other elements …
The rare stable isotope of hydrogen, deuterium, has fascinated researchers since its discovery in the 1930s. ...Deuterium …
Large deuterium isotope effects and their use: a historical review.
Krumbiegel P. Krumbiegel P. Isotopes Environ Health Stud. 2011 Mar;47(1):1-17. doi: 10.1080/10256016.2011.556725. Isotopes Environ Health Stud. 2011. PMID: 21390986 Review.
Large isotope effects of (2)H (deuterium) against (1)H (protium) were seen to possibly influence interpretations of reaction mechanisms if corresponding labelling is used. Much work was invested to ensure the safety of deuterium use in men in spite of …
Large isotope effects of (2)H (deuterium) against (1)H (protium) were seen to possibly influence interpretations of rea …
6,540 results