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Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial.
Dizman N, Meza L, Bergerot P, Alcantara M, Dorff T, Lyou Y, Frankel P, Cui Y, Mira V, Llamas M, Hsu J, Zengin Z, Salgia N, Salgia S, Malhotra J, Chawla N, Chehrazi-Raffle A, Muddasani R, Gillece J, Reining L, Trent J, Takahashi M, Oka K, Higashi S, Kortylewski M, Highlander SK, Pal SK. Dizman N, et al. Nat Med. 2022 Apr;28(4):704-712. doi: 10.1038/s41591-022-01694-6. Epub 2022 Feb 28. Nat Med. 2022. PMID: 35228755 Free PMC article. Clinical Trial.
In this open-label, single-center study (NCT03829111), 30 treatment-naive patients with metastatic renal cell carcinoma with clear cell and/or sarcomatoid histology and intermediate- or poor-risk disease were randomized 2:1 to receive nivolumab and ipilimumab with or without dail …
In this open-label, single-center study (NCT03829111), 30 treatment-naive patients with metastatic renal cell carcinoma with clear cell and/ …
Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial.
Yasukawa Z, Inoue R, Ozeki M, Okubo T, Takagi T, Honda A, Naito Y. Yasukawa Z, et al. Nutrients. 2019 Sep 10;11(9):2170. doi: 10.3390/nu11092170. Nutrients. 2019. PMID: 31509971 Free PMC article. Clinical Trial.
Intake of the PHGG for 3 months significantly improved stool form, evaluated using BSS, and had no effects on stool frequency. ...Our results suggest that intake of PHGG improves human stool form via regulating intestinal microbiota....
Intake of the PHGG for 3 months significantly improved stool form, evaluated using BSS, and had no effects on stool frequency. …
Effect of Tongxie Yaofang Granule in treating diarrhea-predominate irritable bowel syndrome.
Pan F, Zhang T, Zhang YH, Xu JJ, Chen FM. Pan F, et al. Chin J Integr Med. 2009 Jun;15(3):216-9. doi: 10.1007/s11655-009-0216-7. Epub 2009 Jul 2. Chin J Integr Med. 2009. PMID: 19568715 Clinical Trial.
To the intervention group the TXYF granule was given at one package each time, twice a day; the control group was treated with Miyarisan three times a day, two tablets each time. The course of treatment was 4 weeks for both groups. The total efficacy in them was compared, …
To the intervention group the TXYF granule was given at one package each time, twice a day; the control group was treated with Miyarisan …
Genomic analysis of Shiga toxin-producing Escherichia coli from patients and asymptomatic food handlers in Japan.
Baba H, Kanamori H, Kudo H, Kuroki Y, Higashi S, Oka K, Takahashi M, Yoshida M, Oshima K, Aoyagi T, Tokuda K, Kaku M. Baba H, et al. PLoS One. 2019 Nov 19;14(11):e0225340. doi: 10.1371/journal.pone.0225340. eCollection 2019. PLoS One. 2019. PMID: 31743366 Free PMC article.
In Japan, STEC infection is a notifiable disease, and food handlers are required to undergo routine stool examination for STEC. However, the molecular epidemiology of STEC is not entirely known. ...Among 48 isolates with serotypes found in the patients (serotype O157:H7 an …
In Japan, STEC infection is a notifiable disease, and food handlers are required to undergo routine stool examination for STEC. Howev …
Intestinal distribution and intraluminal localization of orally administered Clostridium butyricum in rats.
Sato R, Tanaka M. Sato R, et al. Microbiol Immunol. 1997;41(9):665-71. doi: 10.1111/j.1348-0421.1997.tb01909.x. Microbiol Immunol. 1997. PMID: 9343816 Free article.
The total viable number of C. butyricum was counted using a selective medium, and viable resting spores were selectively detected by treating the samples with ethanol. To investigate the intraluminal localization of the C. butyricum cells, frozen intestinal tracts were imp …
The total viable number of C. butyricum was counted using a selective medium, and viable resting spores were selectively detected by …