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Items: 1 to 20 of 43


Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis.

Deshpande LS, DeLorenzo RJ.

Neurobiol Dis. 2020 Jan;133:104418. doi: 10.1016/j.nbd.2019.03.006. Epub 2019 Mar 12. Review.


Targeting Intracellular Calcium Stores Alleviates Neurological Morbidities in a DFP-Based Rat Model of Gulf War Illness.

Phillips KF, Santos E, Blair RE, Deshpande LS.

Toxicol Sci. 2019 Jun 1;169(2):567-578. doi: 10.1093/toxsci/kfz070.


Hypothermia Reduces Mortality, Prevents the Calcium Plateau, and Is Neuroprotective Following Status Epilepticus in Rats.

Phillips KF, Deshpande LS, DeLorenzo RJ.

Front Neurol. 2018 Jun 11;9:438. doi: 10.3389/fneur.2018.00438. eCollection 2018.


Chronic Neurological Morbidities and Elevated Hippocampal Calcium Levels in a DFP-Based Rat Model of Gulf War Illness.

Phillips KF, Deshpande LS.

Mil Med. 2018 Mar 1;183(suppl_1):552-555. doi: 10.1093/milmed/usx148.


Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication.

Deshpande LS, Blair RE, Phillips KF, DeLorenzo RJ.

Ann N Y Acad Sci. 2016 Jun;1374(1):176-83. doi: 10.1111/nyas.13122. Epub 2016 Jun 21. Review.


Pharmacological blockade of the calcium plateau provides neuroprotection following organophosphate paraoxon induced status epilepticus in rats.

Deshpande LS, Blair RE, Huang BA, Phillips KF, DeLorenzo RJ.

Neurotoxicol Teratol. 2016 Jul-Aug;56:81-86. doi: 10.1016/ Epub 2016 May 17.


Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness.

Phillips KF, Deshpande LS.

Neurotoxicology. 2016 Jan;52:127-33. doi: 10.1016/j.neuro.2015.11.014. Epub 2015 Nov 24.


Cannabinoids: is there a potential treatment role in epilepsy?

Blair RE, Deshpande LS, DeLorenzo RJ.

Expert Opin Pharmacother. 2015;16(13):1911-4. Epub 2015 Aug 3.


Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity.

Deshpande LS, Phillips K, Huang B, DeLorenzo RJ.

Neurotoxicology. 2014 Sep;44:352-7. doi: 10.1016/j.neuro.2014.08.008. Epub 2014 Aug 27.


Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication.

Deshpande LS, Carter DS, Phillips KF, Blair RE, DeLorenzo RJ.

Neurotoxicology. 2014 Sep;44:17-26. doi: 10.1016/j.neuro.2014.04.006. Epub 2014 Apr 29.


Mechanisms of levetiracetam in the control of status epilepticus and epilepsy.

Deshpande LS, Delorenzo RJ.

Front Neurol. 2014 Jan 31;5:11. doi: 10.3389/fneur.2014.00011. eCollection 2014. Review.


Hypothermia reduces calcium entry via the N-methyl-D-aspartate and ryanodine receptors in cultured hippocampal neurons.

Phillips KF, Deshpande LS, DeLorenzo RJ.

Eur J Pharmacol. 2013 Jan 5;698(1-3):186-92. doi: 10.1016/j.ejphar.2012.10.010. Epub 2012 Oct 17.


Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons.

Deshpande LS, Blair RE, DeLorenzo RJ.

Exp Neurol. 2011 Jun;229(2):264-73. doi: 10.1016/j.expneurol.2011.02.007. Epub 2011 Feb 12.


Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals.

Carter DS, Deshpande LS, Rafiq A, Sombati S, DeLorenzo RJ.

Seizure. 2011 Apr;20(3):218-24. doi: 10.1016/j.seizure.2010.11.022. Epub 2010 Dec 18.


An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges.

Ziobro JM, Deshpande LS, Delorenzo RJ.

Brain Res. 2011 Jan 31;1371:110-20. doi: 10.1016/j.brainres.2010.11.065. Epub 2010 Nov 25.


Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.

Deshpande LS, DeLorenzo RJ.

Neuroreport. 2011 Jan 5;22(1):15-8. doi: 10.1097/WNR.0b013e3283413231.


Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus.

Nagarkatti N, Deshpande LS, Carter DS, DeLorenzo RJ.

Eur J Neurosci. 2010 Jul;32(1):80-8. doi: 10.1111/j.1460-9568.2010.07262.x. Epub 2010 Jun 28.


Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate.

Deshpande LS, Carter DS, Blair RE, DeLorenzo RJ.

Toxicol Sci. 2010 Aug;116(2):623-31. doi: 10.1093/toxsci/kfq157. Epub 2010 May 23.


Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy.

Blair RE, Deshpande LS, Sombati S, Elphick MR, Martin BR, DeLorenzo RJ.

Neuropharmacology. 2009 Sep;57(3):208-18. doi: 10.1016/j.neuropharm.2009.06.007. Epub 2009 Jun 18.


Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis.

Nagarkatti N, Deshpande LS, DeLorenzo RJ.

Expert Rev Neurother. 2009 Jun;9(6):813-24. doi: 10.1586/ern.09.21. Review.

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