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Items: 1 to 20 of 134

1.

Adipose tissue macrophages do not affect atherosclerosis development in mice.

Bijnen M, van de Gaar J, Vroomen M, Gijbels MJ, de Winther M, Schalkwijk CG, Wouters K.

Atherosclerosis. 2018 Dec 19;281:31-37. doi: 10.1016/j.atherosclerosis.2018.12.010. [Epub ahead of print]

PMID:
30654169
2.

Circulating CD14+CD16- classical monocytes do not associate with a vulnerable plaque phenotype, and do not predict secondary events in severe atherosclerotic patients.

Meeuwsen JAL, de Vries JJ, van Duijvenvoorde A, van der Velden S, van der Laan SW, van Koeverden ID, van de Weg SM, de Borst GJ, de Winther MPJ, Kuiper J, Pasterkamp G, Hoefer IE, de Jager SCA; Queen of Hearts Consortium.

J Mol Cell Cardiol. 2019 Jan 7;127:260-269. doi: 10.1016/j.yjmcc.2019.01.002. [Epub ahead of print]

3.

Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

van Beek AA, Van den Bossche J, Mastroberardino PG, de Winther MPJ, Leenen PJM.

Trends Immunol. 2019 Jan 6. pii: S1471-4906(18)30235-7. doi: 10.1016/j.it.2018.12.007. [Epub ahead of print] Review.

PMID:
30626541
4.

A Proinflammatory Gut Microbiota Increases Systemic Inflammation and Accelerates Atherosclerosis.

Brandsma E, Kloosterhuis NJ, Koster M, Dekker DC, Gijbels MJJ, van der Velden S, Ríos-Morales M, van Faassen MJR, Loreti MG, de Bruin A, Fu J, Kuipers F, Bakker BM, Westerterp M, de Winther MPJ, Hofker MH, van de Sluis B, Koonen DPY.

Circ Res. 2019 Jan 4;124(1):94-100. doi: 10.1161/CIRCRESAHA.118.313234.

PMID:
30582442
5.

Macrophage CD40-signaling drives experimental autoimmune encephalomyelitis.

Aarts SABM, Seijkens TTP, Kusters PJH, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CPAA, de Winther MPJ, Kooij G, Lutgens E.

J Pathol. 2018 Nov 24. doi: 10.1002/path.5205. [Epub ahead of print]

PMID:
30471110
6.

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J.

Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092.

7.

Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.

Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Slütter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E.

Eur Heart J. 2018 Nov 17. doi: 10.1093/eurheartj/ehy714. [Epub ahead of print]

PMID:
30452556
8.

Potential epigenetic therapeutics for atherosclerosis treatment.

Nicorescu I, Dallinga GM, de Winther MPJ, Stroes ESG, Bahjat M.

Atherosclerosis. 2018 Oct 8. pii: S0021-9150(18)31425-4. doi: 10.1016/j.atherosclerosis.2018.10.006. [Epub ahead of print] Review.

PMID:
30340764
9.

Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis.

Lacy M, Atzler D, Liu R, de Winther M, Weber C, Lutgens E.

Pharmacol Ther. 2019 Jan;193:50-62. doi: 10.1016/j.pharmthera.2018.08.012. Epub 2018 Aug 25. Review.

PMID:
30149100
10.

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.

Aarts SABM, Reiche ME, den Toom M, Beckers L, Gijbels MJJ, Gerdes N, de Winther MPJ, Lutgens E.

PLoS One. 2018 Aug 10;13(8):e0202150. doi: 10.1371/journal.pone.0202150. eCollection 2018.

11.

Myeloid Kdm6b deficiency results in advanced atherosclerosis.

Neele AE, Gijbels MJJ, van der Velden S, Hoeksema MA, Boshuizen MCS, Prange KHM, Chen HJ, Van den Bossche J, van Roomen CPPA, Shami A, Levels JHM, Kroon J, Lucas T, Dimmeler S, Lutgens E, de Winther MPJ.

Atherosclerosis. 2018 Aug;275:156-165. doi: 10.1016/j.atherosclerosis.2018.05.052. Epub 2018 Jun 1.

12.

Repressing the repressor: Ezh2 mediates macrophage activation.

Neele AE, de Winther MPJ.

J Exp Med. 2018 May 7;215(5):1269-1271. doi: 10.1084/jem.20180479. Epub 2018 Apr 24.

13.

Lipopolysaccharide Lowers Cholesteryl Ester Transfer Protein by Activating F4/80+Clec4f+Vsig4+Ly6C- Kupffer Cell Subsets.

van der Tuin SJL, Li Z, Berbée JFP, Verkouter I, Ringnalda LE, Neele AE, van Klinken JB, Rensen SS, Fu J, de Winther MPJ, Groen AK, Rensen PCN, Willems van Dijk K, Wang Y.

J Am Heart Assoc. 2018 Mar 10;7(6). pii: e008105. doi: 10.1161/JAHA.117.008105.

14.

Noncanonical NF-κB signaling in microvessels of atherosclerotic lesions is associated with inflammation, atheromatous plaque morphology and myocardial infarction.

Maracle CX, Agca R, Helder B, Meeuwsen JAL, Niessen HWM, Biessen EAL, de Winther MPJ, de Jager SCA, Nurmohamed MT, Tas SW.

Atherosclerosis. 2018 Mar;270:33-41. doi: 10.1016/j.atherosclerosis.2018.01.032. Epub 2018 Jan 31.

15.

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E.

J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055.

16.

DARC matter(s) for inflammatory cells.

Atzler D, de Winther MPJ.

Cardiovasc Res. 2018 Feb 1;114(2):e11-e13. doi: 10.1093/cvr/cvx230. No abstract available.

PMID:
29373721
17.

Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases.

Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard BG, Neidhart M, Stroes ESG, Catapano AL, Bekkering S.

Eur Heart J. 2018 Oct 7;39(38):3521-3527. doi: 10.1093/eurheartj/ehx581.

18.

IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.

van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, Koning F, van Kooten C, Rensen PCN, Boon MR, Verbeek JS, van Dijk KW, van Harmelen V.

Int J Obes (Lond). 2018 Feb;42(2):260-269. doi: 10.1038/ijo.2017.209. Epub 2017 Aug 30.

PMID:
28852207
19.

Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils.

van den Berg SM, van Dam AD, Kusters PJH, Beckers L, den Toom M, van der Velden S, Van den Bossche J, van Die I, Boon MR, Rensen PCN, Lutgens E, de Winther MPJ.

J Mol Endocrinol. 2017 Oct;59(3):245-255. doi: 10.1530/JME-17-0112. Epub 2017 Jul 10.

PMID:
28694301
20.

Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis.

Beldman TJ, Senders ML, Alaarg A, Pérez-Medina C, Tang J, Zhao Y, Fay F, Deichmöller J, Born B, Desclos E, van der Wel NN, Hoebe RA, Kohen F, Kartvelishvily E, Neeman M, Reiner T, Calcagno C, Fayad ZA, de Winther MPJ, Lutgens E, Mulder WJM, Kluza E.

ACS Nano. 2017 Jun 27;11(6):5785-5799. doi: 10.1021/acsnano.7b01385. Epub 2017 May 15.

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