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Items: 20


Back to the future: Rational maps for exploring acetylcholine receptor space and time.

Tessier CJG, Emlaw JR, Cao ZQ, Pérez-Areales FJ, Salameh JJ, Prinston JE, McNulty MS, daCosta CJB.

Biochim Biophys Acta Proteins Proteom. 2017 Nov;1865(11 Pt B):1522-1528. doi: 10.1016/j.bbapap.2017.08.006. Epub 2017 Aug 24. Review.


Ancestral Reconstruction Approach to Acetylcholine Receptor Structure and Function.

Prinston JE, Emlaw JR, Dextraze MF, Tessier CJG, Pérez-Areales FJ, McNulty MS, daCosta CJB.

Structure. 2017 Aug 1;25(8):1295-1302.e3. doi: 10.1016/j.str.2017.06.005. Epub 2017 Jul 6.


Improved resolution of single channel dwell times reveals mechanisms of binding, priming, and gating in muscle AChR.

Mukhtasimova N, daCosta CJ, Sine SM.

J Gen Physiol. 2016 Jul;148(1):43-63. doi: 10.1085/jgp.201611584.


Stoichiometry for α-bungarotoxin block of α7 acetylcholine receptors.

daCosta CJ, Free CR, Sine SM.

Nat Commun. 2015 Aug 18;6:8057. doi: 10.1038/ncomms9057.


The role of the M4 lipid-sensor in the folding, trafficking, and allosteric modulation of nicotinic acetylcholine receptors.

Hénault CM, Sun J, Therien JP, daCosta CJ, Carswell CL, Labriola JM, Juranka PF, Baenziger JE.

Neuropharmacology. 2015 Sep;96(Pt B):157-68. doi: 10.1016/j.neuropharm.2014.11.011. Epub 2014 Nov 26. Review.


A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors.

daCosta CJ, Dey L, Therien JP, Baenziger JE.

Nat Chem Biol. 2013 Nov;9(11):701-7. doi: 10.1038/nchembio.1338. Epub 2013 Sep 8.


Gating of pentameric ligand-gated ion channels: structural insights and ambiguities.

daCosta CJ, Baenziger JE.

Structure. 2013 Aug 6;21(8):1271-83. doi: 10.1016/j.str.2013.06.019. Review.


Inter-residue coupling contributes to high-affinity subtype-selective binding of α-bungarotoxin to nicotinic receptors.

Sine SM, Huang S, Li SX, daCosta CJ, Chen L.

Biochem J. 2013 Sep 1;454(2):311-21. doi: 10.1042/BJ20130638.


Stoichiometry for drug potentiation of a pentameric ion channel.

daCosta CJ, Sine SM.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6595-600. doi: 10.1073/pnas.1301909110. Epub 2013 Apr 1.


Molecular mechanisms of acetylcholine receptor-lipid interactions: from model membranes to human biology.

Baenziger JE, daCosta CJB.

Biophys Rev. 2013 Mar;5(1):1-9. doi: 10.1007/s12551-012-0078-7. Epub 2012 May 10. Review.


Single-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.

daCosta CJ, Free CR, Corradi J, Bouzat C, Sine SM.

J Neurosci. 2011 Sep 28;31(39):13870-9. doi: 10.1523/JNEUROSCI.2652-11.2011.


Structural characterization and agonist binding to human α4β2 nicotinic receptors.

daCosta CJ, Michel Sturgeon R, Hamouda AK, Blanton MP, Baenziger JE.

Biochem Biophys Res Commun. 2011 Apr 15;407(3):456-60. doi: 10.1016/j.bbrc.2011.03.026. Epub 2011 Mar 17.


Phospholipase C activity affinity purifies with the Torpedo nicotinic acetylcholine receptor.

Labriola JM, daCosta CJ, Wang S, Figeys D, Smith JC, Sturgeon RM, Baenziger JE.

J Biol Chem. 2010 Apr 2;285(14):10337-43. doi: 10.1074/jbc.M109.071993. Epub 2010 Feb 4.


Anionic lipids allosterically modulate multiple nicotinic acetylcholine receptor conformational equilibria.

daCosta CJ, Medaglia SA, Lavigne N, Wang S, Carswell CL, Baenziger JE.

J Biol Chem. 2009 Dec 4;284(49):33841-9. doi: 10.1074/jbc.M109.048280. Epub 2009 Oct 8.


A lipid-dependent uncoupled conformation of the acetylcholine receptor.

daCosta CJ, Baenziger JE.

J Biol Chem. 2009 Jun 26;284(26):17819-25. doi: 10.1074/jbc.M900030200. Epub 2009 Apr 8.


Lipid composition alters drug action at the nicotinic acetylcholine receptor.

Baenziger JE, Ryan SE, Goodreid MM, Vuong NQ, Sturgeon RM, daCosta CJ.

Mol Pharmacol. 2008 Mar;73(3):880-90. Epub 2007 Nov 30.


Role of glycosylation and membrane environment in nicotinic acetylcholine receptor stability.

daCosta CJ, Kaiser DE, Baenziger JE.

Biophys J. 2005 Mar;88(3):1755-64. Epub 2004 Dec 30.


Phosphatidic acid and phosphatidylserine have distinct structural and functional interactions with the nicotinic acetylcholine receptor.

daCosta CJ, Wagg ID, McKay ME, Baenziger JE.

J Biol Chem. 2004 Apr 9;279(15):14967-74. Epub 2004 Jan 29.


A rapid method for assessing lipid:protein and detergent:protein ratios in membrane-protein crystallization.

daCosta CJ, Baenziger JE.

Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):77-83. Epub 2002 Dec 19.


Lipid-protein interactions at the nicotinic acetylcholine receptor. A functional coupling between nicotinic receptors and phosphatidic acid-containing lipid bilayers.

daCosta CJ, Ogrel AA, McCardy EA, Blanton MP, Baenziger JE.

J Biol Chem. 2002 Jan 4;277(1):201-8. Epub 2001 Oct 26.

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