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Am J Reprod Immunol. 2018 Jul;80(1):e12862. doi: 10.1111/aji.12862. Epub 2018 Apr 17.

Prevalence of HHV-6 in endometrium from women with recurrent implantation failure.

Author information

1
Reproductive Medicine Institute, Evanston, IL, USA.
2
Department Microbiology and Immunology, Clinical Immunology Laboratory, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA.
3
Reproductive Medicine and Immunology, Department of Obstetrics and Gynecology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, USA.
4
Clinic Las Condes, Santiago, Chile.

Abstract

PROBLEM:

To study the prevalence of HHV-6 in endometrial biopsies among women experiencing recurrent implantation failure (RIF) after IVF/ET compared with controls.

METHOD OF STUDY:

Thirty women experiencing RIF after IVF/ET and 10 fertile women participated in the study. All women had endometrial biopsies taken in the luteal phase of their menstrual cycle for an endometrial immune profile (EIP) and HHV-6 mRNA as well as lymphocyte and granulocyte populations. The prevalence of HHV-6 in endometrial biopsies was determined, and biopsies for positive and negative expression of HHV-6 were compared with the results of their EIP and lymphocyte and granulocyte populations.

RESULTS:

Thirty-seven percentage of women with a history of RIF and 0% of controls demonstrated the presence of HHV-6 in their endometrial biopsies. No associations were found when the results of the endometrial immune profile were compared with the presence or absence of HHV-6. Significant increase in neutrophil-specific CD16b mRNA was found in HHV-6-positive samples, and the levels of B cells-related CD19 mRNA were lower in biopsies from women with RIF in comparison with normal controls.

CONCLUSION:

HHV-6 infection is an important factor in RIF.

KEYWORDS:

HHV-6; endometrial biopsy; herpesvirus; recurrent implantation failure

PMID:
29667291
DOI:
10.1111/aji.12862

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