Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 68


Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors.

Namkung Y, LeGouill C, Kumar S, Cao Y, Teixeira LB, Lukasheva V, Giubilaro J, Simões SC, Longpré JM, Devost D, Hébert TE, Piñeyro G, Leduc R, Costa-Neto CM, Bouvier M, Laporte SA.

Sci Signal. 2018 Dec 4;11(559). pii: eaat1631. doi: 10.1126/scisignal.aat1631.


The binding of captopril to angiotensin I-converting enzyme triggers activation of signaling pathways.

Reis RI, Nogueira MD, Campanha-Rodrigues AL, Pereira LM, Andrade MCC, Parreiras-E-Silva LT, Costa-Neto CM, Mortara RA, Casarini DE.

Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C367-C379. doi: 10.1152/ajpcell.00012.2016. Epub 2018 Jun 6.


Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential.

Corrêa MF, Barbosa ÁJR, Teixeira LB, Duarte DA, Simões SC, Parreiras-E-Silva LT, Balbino AM, Landgraf RG, Bouvier M, Costa-Neto CM, Fernandes JPS.

Front Pharmacol. 2017 Nov 14;8:825. doi: 10.3389/fphar.2017.00825. eCollection 2017.


Ang-(1-7) is an endogenous β-arrestin-biased agonist of the AT1 receptor with protective action in cardiac hypertrophy.

Teixeira LB, Parreiras-E-Silva LT, Bruder-Nascimento T, Duarte DA, Simões SC, Costa RM, Rodríguez DY, Ferreira PAB, Silva CAA, Abrao EP, Oliveira EB, Bouvier M, Tostes RC, Costa-Neto CM.

Sci Rep. 2017 Sep 19;7(1):11903. doi: 10.1038/s41598-017-12074-3.


Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats.

Parreiras-E-Silva LT, Vargas-Pinilla P, Duarte DA, Longo D, Espinoza Pardo GV, Dulor Finkler A, Paixão-Côrtes VR, Paré P, Rovaris DL, Oliveira EB, Caceres RA, Gonçalves GL, Bouvier M, Salzano FM, Lucion AB, Costa-Neto CM, Bortolini MC.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9044-9049. doi: 10.1073/pnas.1711687114. Epub 2017 Aug 7.


Chronic treatment with fluoxetine modulates vascular adrenergic responses by inhibition of pre- and post-synaptic mechanisms.

Pereira CA, Rodrigues FL, Ruginsk SG, Zanotto CZ, Rodrigues JA, Duarte DA, Costa-Neto CM, Resstel LB, Carneiro FS, Tostes RC.

Eur J Pharmacol. 2017 Apr 5;800:70-80. doi: 10.1016/j.ejphar.2017.02.029. Epub 2017 Feb 17.


A Pluridimensional View of Biased Agonism.

Costa-Neto CM, Parreiras-E-Silva LT, Bouvier M.

Mol Pharmacol. 2016 Nov;90(5):587-595. Epub 2016 Sep 16. Review.


Host kinin B1 receptor plays a protective role against melanoma progression.

Maria AG, Dillenburg-Pilla P, Reis RI, Floriano EM, Tefé-Silva C, Ramos SG, Pesquero JB, Nahmias C, Costa-Neto CM.

Sci Rep. 2016 Feb 22;6:22078. doi: 10.1038/srep22078.


Highlight: Kinin 2015 at São Paulo, Brazil.

Buck HS, Calixto JB, Pesquero JB, Campos MM, Viel TA, Costa-Neto CM.

Biol Chem. 2016 Apr;397(4):281-2. doi: 10.1515/hsz-2016-0115. No abstract available.


Recent updates on GPCR biased agonism.

Pupo AS, Duarte DA, Lima V, Teixeira LB, Parreiras-E-Silva LT, Costa-Neto CM.

Pharmacol Res. 2016 Oct;112:49-57. doi: 10.1016/j.phrs.2016.01.031. Epub 2016 Feb 2. Review.


A Novel Vasoactive Proline-Rich Oligopeptide from the Skin Secretion of the Frog Brachycephalus ephippium.

Arcanjo DD, Vasconcelos AG, Comerma-Steffensen SG, Jesus JR, Silva LP, Pires Júnior OR, Costa-Neto CM, Oliveira EB, Migliolo L, Franco OL, Restini CB, Paulo M, Bendhack LM, Bemquerer MP, Oliveira AP, Simonsen U, Leite JR.

PLoS One. 2015 Dec 14;10(12):e0145071. doi: 10.1371/journal.pone.0145071. eCollection 2015.


Comparative analyses of downstream signal transduction targets modulated after activation of the AT1 receptor by two β-arrestin-biased agonists.

Santos GA, Duarte DA, Parreiras-E-Silva LT, Teixeira FR, Silva-Rocha R, Oliveira EB, Bouvier M, Costa-Neto CM.

Front Pharmacol. 2015 Jul 1;6:131. doi: 10.3389/fphar.2015.00131. eCollection 2015.


Non-canonical signalling and roles of the vasoactive peptides angiotensins and kinins.

Costa-Neto CM, Duarte DA, Lima V, Maria AG, Prando EC, Rodríguez DY, Santos GA, Souza PP, Parreiras-E-Silva LT.

Clin Sci (Lond). 2014 Jun;126(11):753-74. doi: 10.1042/CS20130414. Review.


The kinin B1 receptor regulates muscle-specific E3 ligases expression and is involved in skeletal muscle mass control.

Parreiras-E-Silva LT, Reis RI, Santos GA, Pires-Oliveira M, Pesquero JB, Gomes MD, Godinho RO, Costa-Neto CM.

Clin Sci (Lond). 2014 Aug;127(3):185-94. doi: 10.1042/CS20130358.


Receptor MAS protects mice against hypothermia and mortality induced by endotoxemia.

Souza LL, Duchene J, Todiras M, Azevedo LC, Costa-Neto CM, Alenina N, Santos RA, Bader M.

Shock. 2014 Apr;41(4):331-6. doi: 10.1097/SHK.0000000000000115.


Angiotensin II-independent angiotensin-(1-7) formation in rat hippocampus: involvement of thimet oligopeptidase.

Pereira MG, Souza LL, Becari C, Duarte DA, Camacho FR, Oliveira JA, Gomes MD, Oliveira EB, Salgado MC, Garcia-Cairasco N, Costa-Neto CM.

Hypertension. 2013 Nov;62(5):879-85. doi: 10.1161/HYPERTENSIONAHA.113.01613. Epub 2013 Sep 16.


Activation of the kinin B1 receptor attenuates melanoma tumor growth and metastasis.

Dillenburg-Pilla P, Maria AG, Reis RI, Floriano EM, Pereira CD, De Lucca FL, Ramos SG, Pesquero JB, Jasiulionis MG, Costa-Neto CM.

PLoS One. 2013 May 17;8(5):e64453. doi: 10.1371/journal.pone.0064453. Print 2013.


Hydrogen peroxide production regulates the mitochondrial function in insulin resistant muscle cells: effect of catalase overexpression.

Barbosa MR, Sampaio IH, Teodoro BG, Sousa TA, Zoppi CC, Queiroz AL, Passos MA, Alberici LC, Teixeira FR, Manfiolli AO, Batista TM, Cappelli AP, Reis RI, Frasson D, Kettelhut IC, Parreiras-e-Silva LT, Costa-Neto CM, Carneiro EM, Curi R, Silveira LR.

Biochim Biophys Acta. 2013 Oct;1832(10):1591-604. doi: 10.1016/j.bbadis.2013.04.029. Epub 2013 May 2.


Shear stress-induced Ang II AT1 receptor activation: G-protein dependent and independent mechanisms.

Barauna VG, Magalhaes FC, Campos LC, Reis RI, Kunapuli SP, Costa-Neto CM, Miyakawa AA, Krieger JE.

Biochem Biophys Res Commun. 2013 May 10;434(3):647-52. doi: 10.1016/j.bbrc.2013.04.005. Epub 2013 Apr 11.


Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway.

Axelband F, Dias J, Miranda F, Ferrão FM, Reis RI, Costa-Neto CM, Lara LS, Vieyra A.

Regul Pept. 2012 Aug 20;177(1-3):27-34. doi: 10.1016/j.regpep.2012.04.004. Epub 2012 May 3.

Supplemental Content

Loading ...
Support Center