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Items: 20

1.

The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation.

Tcymbarevich IV, Eloranta JJ, Rossel JB, Obialo N, Spalinger M, Cosin-Roger J, Lang S, Kullak-Ublick GA, Wagner CA, Scharl M, Seuwen K, Ruiz PA, Rogler G, de Vallière C, Misselwitz B; Swiss IBD Cohort Study Group.

BMC Gastroenterol. 2019 Jan 7;19(1):2. doi: 10.1186/s12876-018-0922-8.

2.

Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease.

Tcymbarevich I, Richards SM, Russo G, Kühn-Georgijevic J, Cosin-Roger J, Baebler K, Lang S, Bengs S, Atrott K, Bettoni C, Gruber S, Frey-Wagner I, Scharl M, Misselwitz B, Wagner CA, Seuwen K, Rogler G, Ruiz PA, Spalinger M, de Vallière C.

J Crohns Colitis. 2018 Oct 9. doi: 10.1093/ecco-jcc/jjy152. [Epub ahead of print]

PMID:
30535144
3.

Succinate receptor mediates intestinal inflammation and fibrosis.

Macias-Ceja DC, Ortiz-Masiá D, Salvador P, Gisbert-Ferrándiz L, Hernández C, Hausmann M, Rogler G, Esplugues JV, Hinojosa J, Alós R, Navarro F, Cosin-Roger J, Calatayud S, Barrachina MD.

Mucosal Immunol. 2019 Jan;12(1):178-187. doi: 10.1038/s41385-018-0087-3. Epub 2018 Oct 2.

PMID:
30279517
4.

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.

Cosin-Roger J, Spalinger MR, Ruiz PA, Stanzel C, Terhalle A, Wolfram L, Melhem H, Atrott K, Lang S, Frey-Wagner I, Fried M, Scharl M, Hausmann M, Rogler G.

PLoS One. 2018 Feb 15;13(2):e0193003. doi: 10.1371/journal.pone.0193003. eCollection 2018.

5.

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.

Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA.

Nat Commun. 2017 Jul 24;8(1):98. doi: 10.1038/s41467-017-00213-3.

6.

Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis.

Macias-Ceja DC, Cosín-Roger J, Ortiz-Masiá D, Salvador P, Hernández C, Esplugues JV, Calatayud S, Barrachina MD.

Br J Pharmacol. 2017 Aug;174(15):2501-2511. doi: 10.1111/bph.13860. Epub 2017 Jun 21.

7.

Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms.

Melhem H, Spalinger MR, Cosin-Roger J, Atrott K, Lang S, Wojtal KA, Vavricka SR, Rogler G, Frey-Wagner I.

J Crohns Colitis. 2017 Jul 1;11(7):871-884. doi: 10.1093/ecco-jcc/jjx016.

PMID:
28199527
8.

Hypoxia Positively Regulates the Expression of pH-Sensing G-Protein-Coupled Receptor OGR1 (GPR68).

de Vallière C, Cosin-Roger J, Simmen S, Atrott K, Melhem H, Zeitz J, Madanchi M, Tcymbarevich I, Fried M, Kullak-Ublick GA, Vavricka SR, Misselwitz B, Seuwen K, Wagner CA, Eloranta JJ, Rogler G, Ruiz PA.

Cell Mol Gastroenterol Hepatol. 2016 Jun 25;2(6):796-810. doi: 10.1016/j.jcmgh.2016.06.003. eCollection 2016 Nov.

9.

The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis.

Macias-Ceja DC, Cosín-Roger J, Ortiz-Masiá D, Salvador P, Hernández C, Calatayud S, Esplugues JV, Barrachina MD.

Clin Nutr. 2016 Dec;35(6):1333-1339. doi: 10.1016/j.clnu.2016.02.013. Epub 2016 Feb 23.

PMID:
26948401
10.

Decreased Fibrogenesis After Treatment with Pirfenidone in a Newly Developed Mouse Model of Intestinal Fibrosis.

Meier R, Lutz C, Cosín-Roger J, Fagagnini S, Bollmann G, Hünerwadel A, Mamie C, Lang S, Tchouboukov A, Weber FE, Weber A, Rogler G, Hausmann M.

Inflamm Bowel Dis. 2016 Mar;22(3):569-82. doi: 10.1097/MIB.0000000000000716.

11.

M1 Macrophages Activate Notch Signalling in Epithelial Cells: Relevance in Crohn's Disease.

Ortiz-Masiá D, Cosín-Roger J, Calatayud S, Hernández C, Alós R, Hinojosa J, Esplugues JV, Barrachina MD.

J Crohns Colitis. 2016 May;10(5):582-92. doi: 10.1093/ecco-jcc/jjw009. Epub 2016 Jan 22.

12.

The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD.

Cosín-Roger J, Ortiz-Masiá D, Calatayud S, Hernández C, Esplugues JV, Barrachina MD.

Mucosal Immunol. 2016 Jul;9(4):986-98. doi: 10.1038/mi.2015.123. Epub 2015 Nov 25.

PMID:
26601901
13.

Mutant HRAS as novel target for MEK and mTOR inhibitors.

Kiessling MK, Curioni-Fontecedro A, Samaras P, Atrott K, Cosin-Roger J, Lang S, Scharl M, Rogler G.

Oncotarget. 2015 Dec 8;6(39):42183-96. doi: 10.18632/oncotarget.5619.

14.

Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy.

Hernández C, Barrachina MD, Vallecillo-Hernández J, Álvarez Á, Ortiz-Masiá D, Cosín-Roger J, Esplugues JV, Calatayud S.

J Gastroenterol. 2016 Jul;51(7):691-701. doi: 10.1007/s00535-015-1137-1. Epub 2015 Nov 3.

PMID:
26525539
15.

Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase.

Gerster R, Eloranta JJ, Hausmann M, Ruiz PA, Cosin-Roger J, Terhalle A, Ziegler U, Kullak-Ublick GA, von Eckardstein A, Rogler G.

Cell Mol Gastroenterol Hepatol. 2014 Dec 26;1(2):171-187.e1. doi: 10.1016/j.jcmgh.2014.12.006. eCollection 2015 Mar.

16.

Progastrin represses the alternative activation of human macrophages and modulates their influence on colon cancer epithelial cells.

Hernández C, Barrachina MD, Cosín-Roger J, Ortiz-Masiá D, Álvarez Á, Terrádez L, Nicolau MJ, Alós R, Esplugues JV, Calatayud S.

PLoS One. 2014 Jun 5;9(6):e98458. doi: 10.1371/journal.pone.0098458. eCollection 2014.

17.

Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD.

Ortiz-Masiá D, Cosín-Roger J, Calatayud S, Hernández C, Alós R, Hinojosa J, Apostolova N, Alvarez A, Barrachina MD.

Mucosal Immunol. 2014 Jul;7(4):929-38. doi: 10.1038/mi.2013.108. Epub 2013 Dec 4.

PMID:
24301659
18.

M2 macrophages activate WNT signaling pathway in epithelial cells: relevance in ulcerative colitis.

Cosín-Roger J, Ortiz-Masiá D, Calatayud S, Hernández C, Alvarez A, Hinojosa J, Esplugues JV, Barrachina MD.

PLoS One. 2013 Oct 22;8(10):e78128. doi: 10.1371/journal.pone.0078128. eCollection 2013.

19.

Identification of a novel Pfkfb1 mRNA variant in rat fetal liver.

Cosin-Roger J, Vernia S, Alvarez MS, Cucarella C, Boscá L, Martin-Sanz P, Fernández-Alvarez AJ, Casado M.

Biochem Biophys Res Commun. 2013 Feb 1;431(1):36-40. doi: 10.1016/j.bbrc.2012.12.109. Epub 2013 Jan 3.

PMID:
23291237
20.

Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process.

Ortiz-Masià D, Díez I, Calatayud S, Hernández C, Cosín-Roger J, Hinojosa J, Esplugues JV, Barrachina MD.

PLoS One. 2012;7(10):e48535. doi: 10.1371/journal.pone.0048535. Epub 2012 Oct 31.

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