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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 1
1976 2
1977 1
1979 1
1980 1
1982 1
1983 3
1984 7
1985 5
1986 9
1987 6
1988 9
1989 22
1990 27
1991 33
1992 37
1993 49
1994 46
1995 64
1996 73
1997 87
1998 112
1999 164
2000 225
2001 280
2002 407
2003 470
2004 571
2005 702
2006 915
2007 968
2008 1038
2009 1160
2010 1324
2011 1526
2012 1785
2013 2054
2014 2536
2015 2785
2016 3057
2017 3147
2018 3478
2019 3836
2020 4467
2021 5182
2022 5163
2023 5437
2024 3214

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50,932 results

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Page 1
Genomic Analysis in the Age of Human Genome Sequencing.
Lappalainen T, Scott AJ, Brandt M, Hall IM. Lappalainen T, et al. Cell. 2019 Mar 21;177(1):70-84. doi: 10.1016/j.cell.2019.02.032. Cell. 2019. PMID: 30901550 Free PMC article. Review.
Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. ...However, whi …
Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studi …
GREAP: a comprehensive enrichment analysis software for human genomic regions.
Yang Y, Qian F, Li X, Li Y, Zhou L, Wang Q, Zhou X, Zhang J, Song C, Yu Z, Cui T, Feng C, Zhu J, Shang D, Liu J, Sun M, Zhang Y, Tang H, Li C. Yang Y, et al. Brief Bioinform. 2022 Sep 20;23(5):bbac329. doi: 10.1093/bib/bbac329. Brief Bioinform. 2022. PMID: 35959979
Here, we designed a novel software, Genomic Region sets Enrichment Analysis Platform (GREAP), which provides comprehensive region annotation and enrichment analysis capabilities. ...GREAP provides widespread annotation and enrichment analysis of …
Here, we designed a novel software, Genomic Region sets Enrichment Analysis Platform (GREAP), which provides comprehensive …
Next-Generation Sequencing Technologies.
McCombie WR, McPherson JD, Mardis ER. McCombie WR, et al. Cold Spring Harb Perspect Med. 2019 Nov 1;9(11):a036798. doi: 10.1101/cshperspect.a036798. Cold Spring Harb Perspect Med. 2019. PMID: 30478097 Free PMC article. Review.
Nonetheless, the meteoric increase in sequencing throughput with NGS has dramatically changed our understanding of our genome and ourselves. Sequencing the first human genome as a haploid reference took nearly 10 years but now a full diploid human genome sequ …
Nonetheless, the meteoric increase in sequencing throughput with NGS has dramatically changed our understanding of our genome and our …
The cancer genome.
Stratton MR, Campbell PJ, Futreal PA. Stratton MR, et al. Nature. 2009 Apr 9;458(7239):719-24. doi: 10.1038/nature07943. Nature. 2009. PMID: 19360079 Free PMC article. Review.
All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter of a century much has been learnt about these mutations and the abnormal genes that operate in human cancers. We are now, however, moving i …
All cancers arise as a result of changes that have occurred in the DNA sequence of the genomes of cancer cells. Over the past quarter …
Whole genome sequencing.
Ng PC, Kirkness EF. Ng PC, et al. Methods Mol Biol. 2010;628:215-26. doi: 10.1007/978-1-60327-367-1_12. Methods Mol Biol. 2010. PMID: 20238084 Review.
Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling costs of sequencing technology, we envision paradigm shift from microarray-based genotyping studies to whole genome sequencing. We review …
Whole genome sequencing provides the most comprehensive collection of an individual's genetic variation. With the falling cost …
Clinical sequencing: is WGS the better WES?
Meienberg J, Bruggmann R, Oexle K, Matyas G. Meienberg J, et al. Hum Genet. 2016 Mar;135(3):359-62. doi: 10.1007/s00439-015-1631-9. Epub 2016 Jan 7. Hum Genet. 2016. PMID: 26742503 Free PMC article.
We compared whole exome sequencing (WES) with the most recent PCR-free whole genome sequencing (WGS), showing that only the latter is able to provide hitherto unprecedented complete coverage of the coding region of the genome. Thus, from a clinical/technical point o …
We compared whole exome sequencing (WES) with the most recent PCR-free whole genome sequencing (WGS), showing that only the latter is …
Comprehensive Genomic Analysis Reveals Extensive Diversity of Type I and Type IV Secretion Systems in Klebsiella pneumoniae.
Yang M, Zhou X, Bao Y, Zhang Y, Liu B, Gan L, Tao W, Tuo J, Gong H. Yang M, et al. Curr Microbiol. 2023 Jul 5;80(8):270. doi: 10.1007/s00284-023-03362-5. Curr Microbiol. 2023. PMID: 37402963
In this study, the six common secretion systems (T1SS-T6SS) were comprehensively investigated in the genomes of 952 K. pneumoniae strains. ...
In this study, the six common secretion systems (T1SS-T6SS) were comprehensively investigated in the genomes of 952 K. pneumon …
Comprehensive analysis of genomic variation, pan-genome and biosynthetic potential of Corynebacterium glutamicum strains.
Rahman MS, Shimul MEK, Parvez MAK. Rahman MS, et al. PLoS One. 2024 May 8;19(5):e0299588. doi: 10.1371/journal.pone.0299588. eCollection 2024. PLoS One. 2024. PMID: 38718091 Free PMC article.
Though it is widely accepted at the industrial level, knowledge about the genomic diversity of the strains is limited. Here, we investigated the comparative genomic features of the strains and pan-genomic characteristics. We also observed phylogenetic relatio …
Though it is widely accepted at the industrial level, knowledge about the genomic diversity of the strains is limited. Here, we inves …
Comprehensive dissection of dispensable genomic regions in Streptomyces based on comparative analysis approach.
Bu QT, Li YP, Xie H, Wang J, Li ZY, Chen XA, Mao XM, Li YQ. Bu QT, et al. Microb Cell Fact. 2020 May 6;19(1):99. doi: 10.1186/s12934-020-01359-4. Microb Cell Fact. 2020. PMID: 32375781 Free PMC article.
RESULTS: Phylogenetic tree analysis revealed that the model strains including S. coelicolor A3(2), S. albus J1074 and S. avermitilis MA-4680 were preferred reference for comparative analysis of candidate genomes. ...These results suggested that large-scale de …
RESULTS: Phylogenetic tree analysis revealed that the model strains including S. coelicolor A3(2), S. albus J1074 and S. avermitilis …
Comprehensive pan-genome analysis of Lactiplantibacillus plantarum complete genomes.
Carpi FM, Coman MM, Silvi S, Picciolini M, Verdenelli MC, Napolioni V. Carpi FM, et al. J Appl Microbiol. 2022 Jan;132(1):592-604. doi: 10.1111/jam.15199. Epub 2021 Jul 24. J Appl Microbiol. 2022. PMID: 34216519 Free PMC article.
Considering our updated list of PMGs, we determined that approximatively 70% of the PMGs belongs to the core/soft-core genome. CONCLUSIONS: The comparative genomic analysis conducted in this study provide new insights into the genomic content and varia …
Considering our updated list of PMGs, we determined that approximatively 70% of the PMGs belongs to the core/soft-core genome. CONCLU …
50,932 results
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