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Items: 1 to 20 of 46


Network pharmacology-based identification of the protective mechanisms of taraxasterol in experimental colitis.

Chen W, Da W, Li C, Fan H, Liang R, Yuan J, Huang X, Yang R, Zhang J, Zhu J.

Int Immunopharmacol. 2019 Jun;71:259-266. doi: 10.1016/j.intimp.2019.03.042. Epub 2019 Mar 28.


Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease.

Ning L, Lou X, Zhang F, Xu G.

Mediators Inflamm. 2019 Jan 21;2019:2624941. doi: 10.1155/2019/2624941. eCollection 2019. Review.


Constitutive androstane receptor and pregnane X receptor cooperatively ameliorate DSS-induced colitis.

Uehara D, Tojima H, Kakizaki S, Yamazaki Y, Horiguchi N, Takizawa D, Sato K, Yamada M, Uraoka T.

Dig Liver Dis. 2019 Feb;51(2):226-235. doi: 10.1016/j.dld.2018.10.008. Epub 2018 Oct 22.


Biochemical Markers, Genotype, and Inflammation in Pediatric Inflammatory Bowel Disease: A Danish Population-Based Study.

Ziade F, Rungoe C, Kallemose T, Paerregaard A, Wewer AV, Jakobsen C.

Dig Dis. 2019;37(2):140-146. doi: 10.1159/000494215. Epub 2018 Nov 13.


Activating the pregnane X receptor by imperatorin attenuates dextran sulphate sodium-induced colitis in mice.

Liu M, Zhang G, Zheng C, Song M, Liu F, Huang X, Bai S, Huang X, Lin C, Zhu C, Hu Y, Mi S, Liu C.

Br J Pharmacol. 2018 Sep;175(17):3563-3580. doi: 10.1111/bph.14424. Epub 2018 Jul 23.


Berberine Upregulates P-Glycoprotein in Human Caco-2 Cells and in an Experimental Model of Colitis in the Rat via Activation of Nrf2-Dependent Mechanisms.

Jing W, Safarpour Y, Zhang T, Guo P, Chen G, Wu X, Fu Q, Wang Y.

J Pharmacol Exp Ther. 2018 Aug;366(2):332-340. doi: 10.1124/jpet.118.249615. Epub 2018 Jun 11.


Cell-Surface and Nuclear Receptors in the Colon as Targets for Bacterial Metabolites and Its Relevance to Colon Health.

Sivaprakasam S, Bhutia YD, Ramachandran S, Ganapathy V.

Nutrients. 2017 Aug 10;9(8). pii: E856. doi: 10.3390/nu9080856. Review.


Pregnane X Receptor Polymorphisms and Risk of Inflammatory Bowel Disease: A Meta-Analysis.

Guo X, Yan M.

Immunol Invest. 2017 Aug;46(6):566-576. doi: 10.1080/08820139.2017.1322101. Epub 2017 Jul 25.


Constitutive androstane receptor regulates the intestinal mucosal response to injury.

Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA.

Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19.


Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation.

Kodama S, Shimura T, Kuribayashi H, Abe T, Yoshinari K.

Toxicol Lett. 2017 Apr 5;271:58-65. doi: 10.1016/j.toxlet.2017.02.018. Epub 2017 Feb 22.


Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory conditions and dampens Crohn's disease-like ileitis.

Van den Bossche L, Borsboom D, Devriese S, Van Welden S, Holvoet T, Devisscher L, Hindryckx P, De Vos M, Laukens D.

Lab Invest. 2017 May;97(5):519-529. doi: 10.1038/labinvest.2017.6. Epub 2017 Feb 6.


Relationship between NR1I2 polymorphisms and inflammatory bowel disease risk: A systematic review and meta-analysis.

Sun MY, Lin JN.

Clin Res Hepatol Gastroenterol. 2017 Mar;41(2):230-239. doi: 10.1016/j.clinre.2016.10.006. Epub 2016 Nov 25. Review.


Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.

Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2016 Oct;359(1):91-101. doi: 10.1124/jpet.116.234096. Epub 2016 Jul 20.


Rifaximin Improves Clostridium difficile Toxin A-Induced Toxicity in Caco-2 Cells by the PXR-Dependent TLR4/MyD88/NF-κB Pathway.

Esposito G, Nobile N, Gigli S, Seguella L, Pesce M, d'Alessandro A, Bruzzese E, Capoccia E, Steardo L, Cuomo R, Sarnelli G.

Front Pharmacol. 2016 May 9;7:120. doi: 10.3389/fphar.2016.00120. eCollection 2016.


Tanshinone IIA ameliorates dextran sulfate sodium-induced inflammatory bowel disease via the pregnane X receptor.

Zhang X, Wang Y, Ma Z, Liang Q, Tang X, Hu D, Tan H, Xiao C, Gao Y.

Drug Des Devel Ther. 2015 Dec 7;9:6343-62. doi: 10.2147/DDDT.S79388. eCollection 2015.


Review article: the potential mechanisms of action of rifaximin in the management of inflammatory bowel diseases.

Sartor RB.

Aliment Pharmacol Ther. 2016 Jan;43 Suppl 1:27-36. doi: 10.1111/apt.13436. Review.


Ginsenosides Regulate PXR/NF-κB Signaling and Attenuate Dextran Sulfate Sodium-Induced Colitis.

Zhang J, Cao L, Wang H, Cheng X, Wang L, Zhu L, Yan T, Xie Y, Wu Y, Zhao M, Ma S, Wu M, Wang G, Hao H.

Drug Metab Dispos. 2015 Aug;43(8):1181-9. doi: 10.1124/dmd.115.063800. Epub 2015 May 18.


The protective effect of piperine on dextran sulfate sodium induced inflammatory bowel disease and its relation with pregnane X receptor activation.

Hu D, Wang Y, Chen Z, Ma Z, You Q, Zhang X, Liang Q, Tan H, Xiao C, Tang X, Gao Y.

J Ethnopharmacol. 2015 Jul 1;169:109-23. doi: 10.1016/j.jep.2015.04.006. Epub 2015 Apr 21.


St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins.

Sehirli AO, Cetinel S, Ozkan N, Selman S, Tetik S, Yuksel M, Dulger FG.

J Physiol Pharmacol. 2015 Apr;66(2):203-14.


Expression of hepatic cytochrome P450 in a mouse model of ulcerative colitis changes with pathological conditions.

Kusunoki Y, Ikarashi N, Matsuda S, Matsukawa Y, Kitaoka S, Kon R, Tajima M, Wakui N, Ochiai W, Machida Y, Sugiyama K.

J Gastroenterol Hepatol. 2015 Nov;30(11):1618-26. doi: 10.1111/jgh.12966.


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