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Brain Res. 2005 Nov 30;1063(2):201-3. Epub 2005 Nov 2.

Normal hypocretin-1 (orexin-A) levels in the cerebrospinal fluid of patients with Huntington's disease.

Author information

1
Department of Psychiatry and Psychotherapy, Sleep Disorders Center, Georg-August-University, von-Siebold-Strasse 5, 37075 Goettingen, Germany. ameier2@gwdg.de

Abstract

A significant atrophy and loss of hypocretin neurons in the brains of human patients with Huntington's disease (HD) and in R6/2 mice have been reported. We included 10 patients with HD and 12 patients with chorea-like hyperkinetic movement disorders (non-HD). All patients of the HD group and eleven patients of the non-HD group showed normal hypocretin-1 levels. Thus, hypocretin-1 may not serve as an additional diagnostic marker for HD.

PMID:
16263095
DOI:
10.1016/j.brainres.2005.09.028
[Indexed for MEDLINE]

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