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2002 1
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31 results

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Curcumin Decreases Viability and Inhibits Proliferation of Imatinib-Sensitive and Imatinib-Resistant Chronic Myeloid Leukemia Cell Lines.
Bilajac E, Mahmutović L, Glamočlija U, Osmanović A, Hromić-Jahjefendić A, Tambuwala MM, Suljagić M. Bilajac E, et al. Metabolites. 2022 Dec 30;13(1):58. doi: 10.3390/metabo13010058. Metabolites. 2022. PMID: 36676983 Free PMC article.
We have evaluated curcumin's effects on imatinib-sensitive LAMA84S and K562, as well as imatinib-resistant LAMA84R cell lines. ...Altogether, these results indicate the potential role of curcumin in the treatment of CML....
We have evaluated curcumin's effects on imatinib-sensitive LAMA84S and K562, as well as imatinib-resistant LAMA84R cell lines. …
Efficacy of phytosomal curcumin among patients with non-alcoholic fatty liver disease.
Mirhafez SR, Rezai A, Dehabeh M, Nobakht M Gh BF, Bidkhori M, Sahebkar A, Hariri M. Mirhafez SR, et al. Int J Vitam Nutr Res. 2021 Jun;91(3-4):278-286. doi: 10.1024/0300-9831/a000629. Epub 2019 Dec 10. Int J Vitam Nutr Res. 2021. PMID: 31818232 Clinical Trial.
Scientists proposed that curcumin could be used for treatment of non-alcoholic fatty liver disease (NAFLD). ...Patients in the curcumin group received 250 mg/day of phytosomal curcumin, while those in the control group received 250 mg/day of placebo for durat …
Scientists proposed that curcumin could be used for treatment of non-alcoholic fatty liver disease (NAFLD). ...Patients in the cur …
Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21.
Taverna S, Giallombardo M, Pucci M, Flugy A, Manno M, Raccosta S, Rolfo C, De Leo G, Alessandro R. Taverna S, et al. Oncotarget. 2015 Sep 8;6(26):21918-33. doi: 10.18632/oncotarget.4204. Oncotarget. 2015. PMID: 26116834 Free PMC article.
The addition of Curcumin, to Chronic Myelogenous Leukemia (CML) cells, caused a dose-dependent increase of PTEN, target of miR-21. ...Furthermore, we showed that addition of Curcumin to CML cells caused a downregulation of Bcr-Abl expression through th …
The addition of Curcumin, to Chronic Myelogenous Leukemia (CML) cells, caused a dose-dependent increase of PTEN, target of miR …
[Effect of curcumin on STAT5 signaling pathway in primary CML cells].
Chen WH, Chen Y, Cui GH, Gu JX, Hu D, Chen WK, Li XG. Chen WH, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004 Oct;12(5):572-6. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2004. PMID: 15498113 Chinese.
To study the effect of curcumin on signaling pathway of signal transducers and activators of transcription (STAT5) in primary newly-diagnosed chronic myelocytic leukemia (CML) cells, and to explore the clinical significance of curcumin in the treatment of pri …
To study the effect of curcumin on signaling pathway of signal transducers and activators of transcription (STAT5) in primary newly-d …
SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1alpha axis.
Monteleone F, Taverna S, Alessandro R, Fontana S. Monteleone F, et al. J Exp Clin Cancer Res. 2018 Jul 25;37(1):170. doi: 10.1186/s13046-018-0843-y. J Exp Clin Cancer Res. 2018. PMID: 30045750 Free PMC article.
Imatinib (gleevec, STI-571) is a selective inhibitor of BCR-ABL activity highly effective in the treatment of CML. However, even though almost all CML patients respond to treatment with imatinib or third generation inhibitors, these drugs are not curative and need t …
Imatinib (gleevec, STI-571) is a selective inhibitor of BCR-ABL activity highly effective in the treatment of CML. However, even thou …
Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth.
Larasati YA, Yoneda-Kato N, Nakamae I, Yokoyama T, Meiyanto E, Kato JY. Larasati YA, et al. Sci Rep. 2018 Feb 1;8(1):2039. doi: 10.1038/s41598-018-20179-6. Sci Rep. 2018. PMID: 29391517 Free PMC article.
In the present study, we confirmed the anti-tumorigenic effects of curcumin on CML-derived leukemic cells in a xenograft model and in vitro culture system. ...Curcumin increased ROS levels over the threshold in leukemic cells, and the antioxidant, glutathione …
In the present study, we confirmed the anti-tumorigenic effects of curcumin on CML-derived leukemic cells in a xenograft model …
Curcumin and Curcumin-Loaded Nanogel Induce Apoptosis Activity in K562 Chronic Myelogenous Leukemia Cells.
Khatamsaz S, Hashemi M. Khatamsaz S, et al. Galen Med J. 2018 Feb 23;7:e921. doi: 10.22086/gmj.v0i0.921. eCollection 2018. Galen Med J. 2018. PMID: 34466417 Free PMC article.
Different nanodrug concentrations were prepared and evaluated on the K562 CML cell line. The apoptotic activities of curcumin and nanodrug on the cells were detected by flow cytometry, MTT assay, and trypan blue staining. ...Apoptosis of the K562 cell line occurred …
Different nanodrug concentrations were prepared and evaluated on the K562 CML cell line. The apoptotic activities of curcumin …
Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression.
Nakamae I, Morimoto T, Shima H, Shionyu M, Fujiki H, Yoneda-Kato N, Yokoyama T, Kanaya S, Kakiuchi K, Shirai T, Meiyanto E, Kato JY. Nakamae I, et al. Molecules. 2019 Nov 10;24(22):4067. doi: 10.3390/molecules24224067. Molecules. 2019. PMID: 31717651 Free PMC article.
BACKGROUND: Curcumin has been shown to exert pleiotropic biological effects, including anti-tumorigenic activity. ...In this study, we synthesized 39 novel curcumin derivatives and examined their anti-proliferative and anti-tumorigenic properties. ...
BACKGROUND: Curcumin has been shown to exert pleiotropic biological effects, including anti-tumorigenic activity. ...In this study, w …
Curcumin Prevents the Glycation of Tricarboxylic Acid Cycle and Cell Respiration Proteins in the Heart of Mice Fed with a High-fructose Diet.
León-García MC, Silva-Gaona OG, Hernández-Ortiz M, Vargas-Ortiz K, Ramírez-Emiliano J, Garay-Sevilla ME, Encarnación-Guevara S, Pérez-Vázquez V. León-García MC, et al. Curr Pharm Des. 2022;28(21):1769-1778. doi: 10.2174/1381612828666220331160501. Curr Pharm Des. 2022. PMID: 35362381
The latter is related to a higher risk of cardiovascular disease. Curcumin is a natural pleiotropic compound that may possess antiglycant properties. ...RESULTS: Fourteen glycated protein spots were detected, two of them with anti-AGE and the other 12 with anti- CML …
The latter is related to a higher risk of cardiovascular disease. Curcumin is a natural pleiotropic compound that may possess antigly …
Curcumin modulates chronic myelogenous leukemia exosomes composition and affects angiogenic phenotype via exosomal miR-21.
Taverna S, Fontana S, Monteleone F, Pucci M, Saieva L, De Caro V, Cardinale VG, Giallombardo M, Vicario E, Rolfo C, Leo GD, Alessandro R. Taverna S, et al. Oncotarget. 2016 May 24;7(21):30420-39. doi: 10.18632/oncotarget.8483. Oncotarget. 2016. PMID: 27050372 Free PMC article.
Exosomes released by CML cells treated with Curcumin contain a high amount of miR-21 that is shuttled into the endothelial cells in a biologically active form. The treatment of HUVECs with CML Curcu-exosomes reduced RhoB expression and negatively modulated en …
Exosomes released by CML cells treated with Curcumin contain a high amount of miR-21 that is shuttled into the endothelial cel …
31 results