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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1956 1
1957 1
1958 2
1959 2
1960 6
1962 2
1963 4
1964 5
1965 3
1966 5
1967 7
1968 8
1969 11
1970 11
1971 26
1972 28
1973 22
1974 27
1975 76
1976 95
1977 97
1978 76
1979 100
1980 109
1981 155
1982 153
1983 175
1984 197
1985 216
1986 197
1987 239
1988 289
1989 273
1990 298
1991 326
1992 339
1993 356
1994 403
1995 396
1996 461
1997 486
1998 565
1999 623
2000 713
2001 836
2002 886
2003 928
2004 1093
2005 1140
2006 1239
2007 1294
2008 1365
2009 1392
2010 1540
2011 1519
2012 1647
2013 1729
2014 1754
2015 1731
2016 1730
2017 1825
2018 1765
2019 1932
2020 2081
2021 2292
2022 2025
2023 2002
2024 921

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39,749 results

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Page 1
Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis.
Musumeci G, Castrogiovanni P, Trovato FM, Weinberg AM, Al-Wasiyah MK, Alqahtani MH, Mobasheri A. Musumeci G, et al. Int J Mol Sci. 2015 Aug 31;16(9):20560-75. doi: 10.3390/ijms160920560. Int J Mol Sci. 2015. PMID: 26334269 Free PMC article. Review.
Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the pathogenesis of OA. Identification of biomarkers of chondrocyte apoptosis may facili …
Cell death with morphological and molecular features of apoptosis has been detected in osteoarthritic (OA) cartilage, which suggests a key r …
Runx2, an inducer of osteoblast and chondrocyte differentiation.
Komori T. Komori T. Histochem Cell Biol. 2018 Apr;149(4):313-323. doi: 10.1007/s00418-018-1640-6. Epub 2018 Jan 22. Histochem Cell Biol. 2018. PMID: 29356961 Review.
Runx2(+) osteoprogenitors retain the capacity to differentiate into chondrocytes, and Sp7 and canonical Wnt signaling direct cells to osteoblasts, thereby inhibiting chondrocyte differentiation. ...Runx2 enhances chondrocyte proliferation through the inductio …
Runx2(+) osteoprogenitors retain the capacity to differentiate into chondrocytes, and Sp7 and canonical Wnt signaling direct cells to …
Chondrocyte De-Differentiation: Biophysical Cues to Nuclear Alterations.
Al-Maslamani NA, Oldershaw R, Tew S, Curran J, D'Hooghe P, Yamamoto K, Horn HF. Al-Maslamani NA, et al. Cells. 2022 Dec 12;11(24):4011. doi: 10.3390/cells11244011. Cells. 2022. PMID: 36552775 Free PMC article. Review.
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. ...We propose that manipulating chondrocyte nuclear architecture and chromatin organization will highlight mechanisms that will help to preserve the chondrocyte phenotype …
Autologous chondrocyte implantation (ACI) is a cell therapy to repair cartilage defects. ...We propose that manipulating chondrocy …
Glutamine Metabolism Controls Chondrocyte Identity and Function.
Stegen S, Rinaldi G, Loopmans S, Stockmans I, Moermans K, Thienpont B, Fendt SM, Carmeliet P, Carmeliet G. Stegen S, et al. Dev Cell. 2020 Jun 8;53(5):530-544.e8. doi: 10.1016/j.devcel.2020.05.001. Epub 2020 May 28. Dev Cell. 2020. PMID: 32470321 Free article.
Here, we show that chondrocyte identity and function are closely linked with glutamine metabolism in a feedforward process. ...Second, transaminase-mediated aspartate synthesis supports chondrocyte proliferation and matrix synthesis. Third, glutamine-derived glutath …
Here, we show that chondrocyte identity and function are closely linked with glutamine metabolism in a feedforward process. ...Second …
A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation.
Kozhemyakina E, Lassar AB, Zelzer E. Kozhemyakina E, et al. Development. 2015 Mar 1;142(5):817-31. doi: 10.1242/dev.105536. Development. 2015. PMID: 25715393 Free PMC article. Review.
Decades of work have identified the signaling pathways that regulate the differentiation of chondrocytes during bone formation, from their initial induction from mesenchymal progenitor cells to their terminal maturation into hypertrophic chondrocytes. Here, we revie …
Decades of work have identified the signaling pathways that regulate the differentiation of chondrocytes during bone formation, from …
Molecular Processes in Chondrocyte Biology.
Komori T. Komori T. Int J Mol Sci. 2020 Jun 11;21(11):4161. doi: 10.3390/ijms21114161. Int J Mol Sci. 2020. PMID: 32545161 Free PMC article.
Chondrocyte biology is a hot topic, because osteoarthritis (OA) is a serious problem in an aging society, but there are no fundamental therapeutic drugs [...]....
Chondrocyte biology is a hot topic, because osteoarthritis (OA) is a serious problem in an aging society, but there are no fundamenta …
Chondrocyte moves: clever strategies?
Morales TI. Morales TI. Osteoarthritis Cartilage. 2007 Aug;15(8):861-71. doi: 10.1016/j.joca.2007.02.022. Epub 2007 Apr 30. Osteoarthritis Cartilage. 2007. PMID: 17467303 Free PMC article. Review.
RESULTS: Investigators from different laboratories have observed chondrocyte motility in vitro. I became interested in the question of whether articular chondrocytes retained their phenotype during their migratory excursions. ...Examples of in vivo studies that have …
RESULTS: Investigators from different laboratories have observed chondrocyte motility in vitro. I became interested in the question o …
Chondrocyte apoptosis in development, aging and disease.
Horton WE Jr, Feng L, Adams C. Horton WE Jr, et al. Matrix Biol. 1998 Jun;17(2):107-15. doi: 10.1016/s0945-053x(98)90024-5. Matrix Biol. 1998. PMID: 9694591 Review.
There is increasing evidence that chondrocyte apoptosis plays an important role in cartilage development, aging and disease. ...Also, it will be of importance to define the relationship between chondrocyte apoptosis and the regulation of chondrocyte-specific …
There is increasing evidence that chondrocyte apoptosis plays an important role in cartilage development, aging and disease. ...Also, …
Chondrocyte Deformations Under Mild Dynamic Loading Conditions.
Komeili A, Otoo BS, Abusara Z, Sibole S, Federico S, Herzog W. Komeili A, et al. Ann Biomed Eng. 2021 Feb;49(2):846-857. doi: 10.1007/s10439-020-02615-9. Epub 2020 Sep 21. Ann Biomed Eng. 2021. PMID: 32959133
Despite extensive research on chondrocyte deformations for static conditions, work for dynamic conditions remains rare. ...We hypothesized that dynamic deformations of chondrocytes vastly differ from those observed under steady-state static strain conditions. ...
Despite extensive research on chondrocyte deformations for static conditions, work for dynamic conditions remains rare. ...We hypothe …
Pathomechanisms of Posttraumatic Osteoarthritis: Chondrocyte Behavior and Fate in a Precarious Environment.
Riegger J, Brenner RE. Riegger J, et al. Int J Mol Sci. 2020 Feb 25;21(5):1560. doi: 10.3390/ijms21051560. Int J Mol Sci. 2020. PMID: 32106481 Free PMC article. Review.
The present review focuses on the underlying pathomechanisms of PTOA and in particular the behavior and fate of the surviving chondrocytes, comprising chondrocyte metabolism, regulated cell death, and phenotypical changes comprising hypertrophy and senescence. ...
The present review focuses on the underlying pathomechanisms of PTOA and in particular the behavior and fate of the surviving chondrocyte …
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