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Items: 6


P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice.

Tang SC, Kort A, Cheung KL, Rosing H, Fukami T, Durmus S, Wagenaar E, Hendrikx JJ, Nakajima M, van Vlijmen BJ, Beijnen JH, Schinkel AH.

Mol Pharm. 2015 Oct 5;12(10):3714-23. doi: 10.1021/acs.molpharmaceut.5b00470. Epub 2015 Sep 15.


No evidence for a direct effect of von Willebrand factor's ABH blood group antigens on von Willebrand factor clearance.

Groeneveld DJ, van Bekkum T, Cheung KL, Dirven RJ, Castaman G, Reitsma PH, van Vlijmen B, Eikenboom J.

J Thromb Haemost. 2015 Apr;13(4):592-600. doi: 10.1111/jth.12867. Epub 2015 Mar 11.


P-glycoprotein, CYP3A, and plasma carboxylesterase determine brain and blood disposition of the mTOR Inhibitor everolimus (Afinitor) in mice.

Tang SC, Sparidans RW, Cheung KL, Fukami T, Durmus S, Wagenaar E, Yokoi T, van Vlijmen BJ, Beijnen JH, Schinkel AH.

Clin Cancer Res. 2014 Jun 15;20(12):3133-45. doi: 10.1158/1078-0432.CCR-13-1759. Epub 2014 Apr 11.


Regulation of the F11, Klkb1, Cyp4v3 gene cluster in livers of metabolically challenged mice.

Safdar H, Cleuren AC, Cheung KL, Gonzalez FJ, Vos HL, Inoue Y, Reitsma PH, van Vlijmen BJ.

PLoS One. 2013 Sep 16;8(9):e74637. doi: 10.1371/journal.pone.0074637. eCollection 2013.


Acute and severe coagulopathy in adult mice following silencing of hepatic antithrombin and protein C production.

Safdar H, Cheung KL, Salvatori D, Versteeg HH, Laghmani el H, Wagenaar GT, Reitsma PH, van Vlijmen BJ.

Blood. 2013 May 23;121(21):4413-6. doi: 10.1182/blood-2012-11-465674. Epub 2013 Apr 2.


Modulation of mouse coagulation gene transcription following acute in vivo delivery of synthetic small interfering RNAs targeting HNF4α and C/EBPα.

Safdar H, Cheung KL, Vos HL, Gonzalez FJ, Reitsma PH, Inoue Y, van Vlijmen BJ.

PLoS One. 2012;7(6):e38104. doi: 10.1371/journal.pone.0038104. Epub 2012 Jun 1.

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