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2016 1
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Page 1
[No title available]
[No authors listed] [No authors listed] PMID: 38175892
Mechanistic understanding of gut irAEs has been hampered because robust colitis is not observed in laboratory mice treated with checkpoint inhibitors. We report here that this limitation can be overcome by using mice harboring the microbiota of wild-caught mi …
Mechanistic understanding of gut irAEs has been hampered because robust colitis is not observed in laboratory mice treated with ch
[No title available]
[No authors listed] [No authors listed] PMID: 30420754 Free article.
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells with …
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal mi
[No title available]
[No authors listed] [No authors listed] PMID: 34941392 Free article.
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but the effect of diet and supplements on this interaction is not well studied. We assessed fecal microbiota profiles, dietary habits, and commercially available probi …
Gut bacteria modulate the response to immune checkpoint blockade (ICB) treatment in cancer, but the effect of diet and supplem …
[No title available]
[No authors listed] [No authors listed] PMID: 34239137
Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across tumor types, but also a high rate of immune-related adverse events. ...Tumor-associated immune and genomic biomarkers of response to CICB w …
Treatment with combined immune checkpoint blockade (CICB) targeting CTLA-4 and PD-1 is associated with clinical benefit across …
[No title available]
[No authors listed] [No authors listed] PMID: 37602831
Dual CTLA4 and PD-1 blockade exacerbated autoimmune colitis, activated an inflammatory response, and promoted myeloid cell infiltration, with higher percentages of macrophages, dendritic cells, monocytes, and neutrophils. ...SIGNIFICANCE: F. prausnitzii allev …
Dual CTLA4 and PD-1 blockade exacerbated autoimmune colitis, activated an inflammatory response, and promoted myeloid cell
[No title available]
[No authors listed] [No authors listed] PMID: 31138779 Free article.
Gegen Qinlian decoction (GQD), a classical traditional Chinese medicine (TCM) formula, has been clinically proven to be effective in the treatment of ulcerative colitis (UC) and type 2 diabetes mellitus. Here, a systemic pharmacological study revealed that GQD acts through …
Gegen Qinlian decoction (GQD), a classical traditional Chinese medicine (TCM) formula, has been clinically proven to be effective in the tre …
[No title available]
[No authors listed] [No authors listed] PMID: 37872166 Free article.
The immune profile of the colon of these mice with CPI-colitis is analysed using bulk RNA sequencing, single-cell RNA sequencing and flow cytometry. ...This pre-clinical model of CPI-colitis could be attenuated following blockade of the IL23/IFNgamma a …
The immune profile of the colon of these mice with CPI-colitis is analysed using bulk RNA sequencing, single-cell RNA sequenci …
[No title available]
[No authors listed] [No authors listed] PMID: 37953676
The wide application of immune checkpoint blockade (ICB) therapy is impeded by the development of ICB-induced colitis, a condition intricately linked to alterations in the gut microbiota. ...Probiotic intervention thus emerges as a promising approach f …
The wide application of immune checkpoint blockade (ICB) therapy is impeded by the development of ICB-induced colitis, …
[No title available]
[No authors listed] [No authors listed] PMID: 31214189 Free article.
Immune checkpoint blockade (ICB) immunotherapy increases antitumor immunity by blocking cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4) or programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) and displays robust clinical responses in …
Immune checkpoint blockade (ICB) immunotherapy increases antitumor immunity by blocking cytotoxic-T-lymphocyte-associated prot …
[No title available]
[No authors listed] [No authors listed] PMID: 36246150 Free article.
Immune checkpoint inhibitors (ICIs) are a new class of cancer pharmacotherapy consisting of antibodies that block inhibitory immune regulators such as cytotoxic T lymphocyte antigen 4, programmed cell death 1 and programmed death-ligand 1. Checkpoint block
Immune checkpoint inhibitors (ICIs) are a new class of cancer pharmacotherapy consisting of antibodies that block inhibitory immune r …
20 results