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Items: 1 to 20 of 21


Single Cell Imaging of Nuclear Architecture Changes.

Morrish RB, Hermes M, Metz J, Stone N, Pagliara S, Chahwan R, Palombo F.

Front Cell Dev Biol. 2019 Jul 24;7:141. doi: 10.3389/fcell.2019.00141. eCollection 2019.


A universal fluorescence-based toolkit for real-time quantification of DNA and RNA nuclease activity.

Sheppard EC, Rogers S, Harmer NJ, Chahwan R.

Sci Rep. 2019 Jun 20;9(1):8853. doi: 10.1038/s41598-019-45356-z.


Epigenomic Modifications Mediating Antibody Maturation.

Sheppard EC, Morrish RB, Dillon MJ, Leyland R, Chahwan R.

Front Immunol. 2018 Feb 26;9:355. doi: 10.3389/fimmu.2018.00355. eCollection 2018. Review.


Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens.

Harmer NJ, Chahwan R.

Virulence. 2016 Aug 17;7(6):623-6. doi: 10.1080/21505594.2016.1193278. Epub 2016 May 25. No abstract available.


Overlapping hotspots in CDRs are critical sites for V region diversification.

Wei L, Chahwan R, Wang S, Wang X, Pham PT, Goodman MF, Bergman A, Scharff MD, MacCarthy T.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):E728-37. doi: 10.1073/pnas.1500788112. Epub 2015 Feb 2.


The MutSĪ² complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair.

van Oers JM, Edwards Y, Chahwan R, Zhang W, Smith C, Pechuan X, Schaetzlein S, Jin B, Wang Y, Bergman A, Scharff MD, Edelmann W.

Oncogene. 2014 Jul 24;33(30):3939-46. doi: 10.1038/onc.2013.365. Epub 2013 Sep 9.


Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.

Schaetzlein S, Chahwan R, Avdievich E, Roa S, Wei K, Eoff RL, Sellers RS, Clark AB, Kunkel TA, Scharff MD, Edelmann W.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):E2470-9. doi: 10.1073/pnas.1308512110. Epub 2013 Jun 10.


RNF8 links nucleosomal and cytoskeletal ubiquitylation of higher order protein structures.

Chahwan R, Gravel S, Matsusaka T, Jackson SP.

Cell Cycle. 2013 Apr 15;12(8):1161-2. doi: 10.4161/cc.24402. Epub 2013 Apr 2. No abstract available.


Dma/RNF8 proteins are evolutionarily conserved E3 ubiquitin ligases that target septins.

Chahwan R, Gravel S, Matsusaka T, Jackson SP.

Cell Cycle. 2013 Mar 15;12(6):1000-8. doi: 10.4161/cc.23947. Epub 2013 Feb 26.


AIDing antibody diversity by error-prone mismatch repair.

Chahwan R, Edelmann W, Scharff MD, Roa S.

Semin Immunol. 2012 Aug;24(4):293-300. doi: 10.1016/j.smim.2012.05.005. Epub 2012 Jun 14. Review.


The ATPase activity of MLH1 is required to orchestrate DNA double-strand breaks and end processing during class switch recombination.

Chahwan R, van Oers JM, Avdievich E, Zhao C, Edelmann W, Scharff MD, Roa S.

J Exp Med. 2012 Apr 9;209(4):671-8. doi: 10.1084/jem.20111531. Epub 2012 Mar 26.


Aicardi-Goutieres syndrome: from patients to genes and beyond.

Chahwan C, Chahwan R.

Clin Genet. 2012 May;81(5):413-20. doi: 10.1111/j.1399-0004.2011.01825.x. Epub 2012 Jan 8. Review.


Mismatch-mediated error prone repair at the immunoglobulin genes.

Chahwan R, Edelmann W, Scharff MD, Roa S.

Biomed Pharmacother. 2011 Dec;65(8):529-36. doi: 10.1016/j.biopha.2011.09.001. Epub 2011 Oct 24. Review.


The multidimensional nature of epigenetic information and its role in disease.

Chahwan R, Wontakal SN, Roa S.

Discov Med. 2011 Mar;11(58):233-43. Review.


Crosstalk between genetic and epigenetic information through cytosine deamination.

Chahwan R, Wontakal SN, Roa S.

Trends Genet. 2010 Oct;26(10):443-8. doi: 10.1016/j.tig.2010.07.005. Epub 2010 Aug 26.


The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination.

Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):809-14. doi: 10.1073/pnas.0913790107. Epub 2009 Dec 22.


Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.

Science. 2007 Dec 7;318(5856):1637-40. Epub 2007 Nov 15.


Involvement of mammalian Mus81 in genome integrity and tumor suppression.

McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-Sweatman O, Khokha R, Kanaar R, Jasin M, Hande MP, Hakem R.

Science. 2004 Jun 18;304(5678):1822-6.


Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells.

Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, Khaw AK, McPherson P, Shehabeldin A, Laister R, Arrowsmith C, Kanaar R, West SC, Jasin M, Hakem R.

EMBO J. 2003 Nov 17;22(22):6137-47.

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