Ligand-mediated negative regulation of a chimeric transmembrane receptor tyrosine phosphatase.
Cell. 1993.
PMID: 8490965
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3
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found by citation matching
v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA.
Cell. 1990.
PMID: 1972036
Close similarity between receptor-linked tyrosine phosphatase and rat brain proteoglycan.
Cell. 1994.
PMID: 8293458
No abstract available.
Search results
Page 1
NK cell recognition of hematopoietic cells by SLAM-SAP families.
Cell Mol Immunol. 2019 May;16(5):452-459. doi: 10.1038/s41423-019-0222-4. Epub 2019 Mar 25.
Cell Mol Immunol. 2019.
PMID: 30911116
Free PMC article.
Review.
The signaling lymphocyte activation molecule (SLAM) family of receptors (SFRs) are ubiquitously expressed on immune cells, and they regulate multiple immune events by recruiting SH2 (Src homology 2) domain-containing SAP family adapters, including SAP and its …
The signaling lymphocyte activation molecule (SLAM) family of receptors (SFRs) are ubiquitously expressed on immune cells, and they r …
Signaling for NKT cell development: the SAP-FynT connection.
J Exp Med. 2005 Mar 21;201(6):833-6. doi: 10.1084/jem.20050339.
J Exp Med. 2005.
PMID: 15781574
Free PMC article.
Review.
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By connecting homotypic SLAM family receptor interactions with the FynT Src kinase, SAP may integrate a set of long-standing yet seeming …
New studies demonstrate a critical role for the adaptor protein SAP (SLAM-associated protein) during NKT cell development. By …
SAP modulates B cell functions in a genetic background-dependent manner.
Immunol Lett. 2013 Jun;153(1-2):15-21. doi: 10.1016/j.imlet.2013.06.003. Epub 2013 Jun 24.
Immunol Lett. 2013.
PMID: 23806511
Free PMC article.
It is however not well understood whether in XLP patients and SAP-/- mice B cell functions are affected, even though B cells themselves do not express SAP. Here we report that B cell intrinsic responses to haptenated protein antigens are impaire …
It is however not well understood whether in XLP patients and SAP-/- mice B cell functions are affected, even though B cell …
Allosteric inhibition of SHP2 rescues functional T-cell abnormalities in SAP deficiency.
J Allergy Clin Immunol. 2022 Dec;150(6):1507-1516.e7. doi: 10.1016/j.jaci.2022.06.021. Epub 2022 Jul 14.
J Allergy Clin Immunol. 2022.
PMID: 35839843
In T cells, SAP relays activatory signals from the T-cell receptor but in its absence SH2 containing protein tyrosine phosphase-1 (SHP1), SH2 containing protein tyrosine phosphase-2 (SHP2), and SH2 containing inositol 5'-phosphatase proteins (SHIP) induce T- …
In T cells, SAP relays activatory signals from the T-cell receptor but in its absence SH2 containing protein tyrosine p …
Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination.
Curr Opin Virol. 2013 Jun;3(3):363-70. doi: 10.1016/j.coviro.2013.05.015. Epub 2013 Jun 3.
Curr Opin Virol. 2013.
PMID: 23743125
Free PMC article.
Review.
Sustained contact between Tfh cells and B cells is necessary for the provision of help to B cells. ...SAP binds to SLAM family receptors and mediates signaling that affects cell adhesion, cytokine secretion, and TCR signaling strength. ...
Sustained contact between Tfh cells and B cells is necessary for the provision of help to B cells. ...SAP binds …
NK cell regulation by SLAM family receptors and SAP-related adapters.
Immunol Rev. 2006 Dec;214:22-34. doi: 10.1111/j.1600-065X.2006.00453.x.
Immunol Rev. 2006.
PMID: 17100873
Review.
Natural killer (NK) cells express at least three members of the SLAM family. They are 2B4, NK, T- and B-cell antigen (NTB-A), and CD2-like receptor-activating cytotoxic cells (CRACC), which recognize their respective ligands CD48, NTB-A, and CRACC on target …
Natural killer (NK) cells express at least three members of the SLAM family. They are 2B4, NK, T- and B-cell antigen (NTB-A), …
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses.
Braz J Med Biol Res. 2011 Apr;44(4):276-82. doi: 10.1590/s0100-879x2011007500038. Epub 2011 Mar 29.
Braz J Med Biol Res. 2011.
PMID: 21445533
Free article.
Review.
The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM- …
The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the …
SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3zeta interactions.
J Immunol. 2014 Oct 15;193(8):3860-71. doi: 10.4049/jimmunol.1401660. Epub 2014 Sep 12.
J Immunol. 2014.
PMID: 25217164
The germinal center response requires cooperation between Ag-specific T and B lymphocytes, which takes the form of long-lasting cell-cell conjugation in vivo. Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is required for stable cog …
The germinal center response requires cooperation between Ag-specific T and B lymphocytes, which takes the form of long-lasting cell- …
T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP.
J Immunol. 2017 Oct 15;199(8):2745-2757. doi: 10.4049/jimmunol.1700557. Epub 2017 Sep 13.
J Immunol. 2017.
PMID: 28904129
Free PMC article.
This interaction induces cell type-specific signals in both cell types, mediated by the SLAM-associated protein (SAP) family of adaptors. ...Thus, naive T cells regulate B cell survival in a SLAMF6- and SAP-dependent manner....
This interaction induces cell type-specific signals in both cell types, mediated by the SLAM-associated protein (SAP) f …
From SAP-less T cells to helpless B cells and back: dynamic T-B cell interactions underlie germinal center development and function.
Immunol Rev. 2012 May;247(1):24-35. doi: 10.1111/j.1600-065X.2012.01119.x.
Immunol Rev. 2012.
PMID: 22500829
Review.
Germinal centers (GCs) are highly organized tissue microdomains in which high affinity, class-switched, antibody-producing cells and humoral immune memory are generated. Critical underlying cell-cell interaction events include at the minimum binary interactio …
Germinal centers (GCs) are highly organized tissue microdomains in which high affinity, class-switched, antibody-producing cells and …
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