Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 943

1.

Aberrant activation of Cdc2/cyclin B1 is involved in initiation of cytoskeletal pathology in murine Niemann-Pick disease type C.

Ba L, Li ZJ, Bu BT, Wang W, Zhang M.

J Huazhong Univ Sci Technolog Med Sci. 2017 Oct;37(5):732-739. doi: 10.1007/s11596-017-1796-7. Epub 2017 Oct 20.

PMID:
29058287
2.

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.

Riggs JR, Nagy M, Elsner J, Erdman P, Cashion D, Robinson D, Harris R, Huang D, Tehrani L, Deyanat-Yazdi G, Narla RK, Peng X, Tran T, Barnes L, Miller T, Katz J, Tang Y, Chen M, Moghaddam MF, Bahmanyar S, Pagarigan B, Delker S, LeBrun L, Chamberlain PP, Calabrese A, Canan SS, Leftheris K, Zhu D, Boylan JF.

J Med Chem. 2017 Nov 9;60(21):8989-9002. doi: 10.1021/acs.jmedchem.7b01223. Epub 2017 Oct 27.

PMID:
28991472
3.

Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers.

Sun QZ, Lin GF, Li LL, Jin XT, Huang LY, Zhang G, Yang W, Chen K, Xiang R, Chen C, Wei YQ, Lu GW, Yang SY.

J Med Chem. 2017 Jul 27;60(14):6337-6352. doi: 10.1021/acs.jmedchem.7b00665. Epub 2017 Jul 17.

PMID:
28692292
4.

The Cdc2/Cdk1 inhibitor, purvalanol A, enhances the cytotoxic effects of taxol through Op18/stathmin in non-small cell lung cancer cells in vitro.

Chen X, Liao Y, Long D, Yu T, Shen F, Lin X.

Int J Mol Med. 2017 Jul;40(1):235-242. doi: 10.3892/ijmm.2017.2989. Epub 2017 May 15.

PMID:
28534969
5.

Heat shock protein 70 promotes coxsackievirus B3 translation initiation and elongation via Akt-mTORC1 pathway depending on activation of p70S6K and Cdc2.

Wang F, Qiu Y, Zhang HM, Hanson P, Ye X, Zhao G, Xie R, Tong L, Yang D.

Cell Microbiol. 2017 Jul;19(7). doi: 10.1111/cmi.12725. Epub 2017 Feb 1.

PMID:
28095607
6.

Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells.

Sun WJ, Huang H, He B, Hu DH, Li PH, Yu YJ, Zhou XH, Lv Z, Zhou L, Hu TY, Yao ZC, Lu MD, Shen X, Zheng ZQ.

Biochem Pharmacol. 2017 Mar 1;127:90-100. doi: 10.1016/j.bcp.2016.12.008. Epub 2016 Dec 22.

PMID:
28012958
7.

Characterization of cyclin-dependent kinases and Cdc2/Cdc28 kinase subunits in Trichomonas vaginalis.

Amador E, López-Pacheco K, Morales N, Coria R, López-Villaseñor I.

Parasitology. 2017 Apr;144(5):571-582. doi: 10.1017/S0031182016002195. Epub 2016 Dec 8.

PMID:
27928981
8.

Cdc2-like kinase 2 in the hypothalamus is necessary to maintain energy homeostasis.

Quaresma PG, Weissmann L, Zanotto TM, Santos AC, de Matos AH, Furigo IC, Simabuco FM, Donato J Jr, Bittencourt JC, Lopes-Cendes I, Prada PO.

Int J Obes (Lond). 2017 Feb;41(2):268-278. doi: 10.1038/ijo.2016.174. Epub 2016 Oct 13.

PMID:
27733761
9.
10.
11.

Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors.

Ganga Reddy V, Srinivasa Reddy T, Lakshma Nayak V, Prasad B, Reddy AP, Ravikumar A, Taj S, Kamal A.

Eur J Med Chem. 2016 Oct 21;122:164-177. doi: 10.1016/j.ejmech.2016.06.011. Epub 2016 Jun 11.

PMID:
27344493
12.

Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2.

Zhang Y, Qian D, Li Z, Huang Y, Wu Q, Ru G, Chen M, Wang B.

Cell Stress Chaperones. 2016 Jul;21(4):687-96. doi: 10.1007/s12192-016-0693-5. Epub 2016 Apr 26.

13.

Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma.

Park SY, Piao Y, Thomas C, Fuller GN, de Groot JF.

Oncotarget. 2016 May 3;7(18):26793-805. doi: 10.18632/oncotarget.8471.

14.

Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade.

Zhang B, Leng C, Wu C, Zhang Z, Dou L, Luo X, Zhang B, Chen X.

Oncol Rep. 2016 Mar;35(3):1807-15. doi: 10.3892/or.2015.4479. Epub 2015 Dec 8.

PMID:
26647806
15.

Two Distinct Cdc2 Pools Regulate Cell Cycle Progression and the DNA Damage Response in the Fission Yeast S.pombe.

Caspari T, Hilditch V.

PLoS One. 2015 Jul 1;10(7):e0130748. doi: 10.1371/journal.pone.0130748. eCollection 2015.

16.

Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk.

Qi LW, Zhang Z, Zhang CF, Anderson S, Liu Q, Yuan CS, Wang CZ.

Am J Chin Med. 2015;43(4):743-56. doi: 10.1142/S0192415X15500469. Epub 2015 Jun 28.

PMID:
26119958
17.

Two Cdc2 Kinase Genes with Distinct Functions in Vegetative and Infectious Hyphae in Fusarium graminearum.

Liu H, Zhang S, Ma J, Dai Y, Li C, Lyu X, Wang C, Xu JR.

PLoS Pathog. 2015 Jun 17;11(6):e1004913. doi: 10.1371/journal.ppat.1004913. eCollection 2015 Jun.

18.

DCIR2+ cDC2 DCs and Zbtb32 Restore CD4+ T-Cell Tolerance and Inhibit Diabetes.

Price JD, Hotta-Iwamura C, Zhao Y, Beauchamp NM, Tarbell KV.

Diabetes. 2015 Oct;64(10):3521-31. doi: 10.2337/db14-1880. Epub 2015 Jun 12.

19.

Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow.

Schlitzer A, Sivakamasundari V, Chen J, Sumatoh HR, Schreuder J, Lum J, Malleret B, Zhang S, Larbi A, Zolezzi F, Renia L, Poidinger M, Naik S, Newell EW, Robson P, Ginhoux F.

Nat Immunol. 2015 Jul;16(7):718-28. doi: 10.1038/ni.3200. Epub 2015 Jun 8.

PMID:
26054720
20.

Nitrosative stress induces a novel intra-S checkpoint pathway in Schizosaccharomyces pombe involving phosphorylation of Cdc2 by Wee1.

Biswas P, Kar P, Ghosh S.

Free Radic Biol Med. 2015 Sep;86:145-55. doi: 10.1016/j.freeradbiomed.2015.05.021. Epub 2015 May 22.

PMID:
26006103

Supplemental Content

Support Center