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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 5
1991 13
1992 30
1993 80
1994 112
1995 165
1996 210
1997 241
1998 258
1999 291
2000 296
2001 306
2002 290
2003 356
2004 306
2005 377
2006 393
2007 378
2008 404
2009 418
2010 407
2011 406
2012 350
2013 365
2014 387
2015 363
2016 312
2017 301
2018 305
2019 293
2020 317
2021 345
2022 318
2023 288
2024 103

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8,979 results

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Page 1
Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis.
Maehara T, Kaneko N, Perugino CA, Mattoo H, Kers J, Allard-Chamard H, Mahajan VS, Liu H, Murphy SJ, Ghebremichael M, Fox D, Payne AS, Lafyatis R, Stone JH, Khanna D, Pillai S. Maehara T, et al. J Clin Invest. 2020 May 1;130(5):2451-2464. doi: 10.1172/JCI131700. J Clin Invest. 2020. PMID: 31990684 Free PMC article. Clinical Trial.
We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. ...A circulating effecto …
We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that C …
Autoimmune Lymphoproliferative Syndrome: An Overview.
Matson DR, Yang DT. Matson DR, et al. Arch Pathol Lab Med. 2020 Feb;144(2):245-251. doi: 10.5858/arpa.2018-0190-RS. Epub 2019 Apr 8. Arch Pathol Lab Med. 2020. PMID: 30958694 Free PMC article. Review.
Autoimmune lymphoproliferative syndrome (ALPS) is an inherited nonmalignant lymphoproliferative disorder characterized by heterozygous mutations within the first apoptosis signal receptor (FAS) signaling pathway. Defects in FAS-mediated apoptosis cause an expansion …
Autoimmune lymphoproliferative syndrome (ALPS) is an inherited nonmalignant lymphoproliferative disorder characterized by heterozygous mutat …
Notch signaling protects CD4 T cells from STING-mediated apoptosis during acute systemic inflammation.
Long J, Yang C, Zheng Y, Loughran P, Guang F, Li Y, Liao H, Scott MJ, Tang D, Billiar TR, Deng M. Long J, et al. Sci Adv. 2020 Sep 23;6(39):eabc5447. doi: 10.1126/sciadv.abc5447. Print 2020 Sep. Sci Adv. 2020. PMID: 32967837 Free PMC article.
Notch was previously identified as the top negative regulator of STING in macrophages through a kinase inhibitor library screening. However, how Notch signaling regulates STING activation in T cells is unknown. Here, using a gamma-secretase inhibitor to block Notch …
Notch was previously identified as the top negative regulator of STING in macrophages through a kinase inhibitor library screening. However, …
IMMUNE CELL PHENOTYPE AND FUNCTION IN SEPSIS.
Rimmelé T, Payen D, Cantaluppi V, Marshall J, Gomez H, Gomez A, Murray P, Kellum JA; ADQI XIV Workgroup. Rimmelé T, et al. Shock. 2016 Mar;45(3):282-91. doi: 10.1097/SHK.0000000000000495. Shock. 2016. PMID: 26529661 Free PMC article. Review.
Reduced expression of HLA-DR is a characteristic finding on septic monocytes, but monocyte antimicrobial function does not appear to be significantly altered in sepsis. Regarding adaptive immunity, sepsis-induced apoptosis leads to lymphopenia in patients with septic shock …
Reduced expression of HLA-DR is a characteristic finding on septic monocytes, but monocyte antimicrobial function does not appear to be sign …
Mitofusin 2 Promotes Apoptosis of CD4(+) T Cells by Inhibiting Autophagy in Sepsis.
Ying L, Zhao GJ, Wu Y, Ke HL, Hong GL, Zhang H, Dong N, Wu Y, Yao YM, Lu ZQ. Ying L, et al. Mediators Inflamm. 2017;2017:4926205. doi: 10.1155/2017/4926205. Epub 2017 Nov 19. Mediators Inflamm. 2017. PMID: 29358849 Free PMC article.
Apoptosis of CD4(+) T cells is a primary pathophysiological mechanism of immune dysfunction in the pathogenesis of sepsis. ...Here, we discovered increased in vivo Mfn2 expression, autophagy deficiency, and elevated cell apoptosis in murine sple …
Apoptosis of CD4(+) T cells is a primary pathophysiological mechanism of immune dysfunction in the pathogenesis …
Vitamin D receptor expression in SLE peripheral blood CD4+T cells is associated with disease activity and cell apoptosis.
Zhang Y, Niu L, Wang F, Tang X, Wang C, Zhu Y. Zhang Y, et al. Mod Rheumatol. 2022 Apr 18;32(3):577-583. doi: 10.1093/mr/roab023. Mod Rheumatol. 2022. PMID: 34897495
The aim of this study was to examine the correlation between CD4+T cells VDR expression, cell apoptosis, and disease activity in patients with SLE. ...The frequency of VDR-positive CD4+T cells, Th1 cells, Th2 cells, Th17 cells, Tre …
The aim of this study was to examine the correlation between CD4+T cells VDR expression, cell apoptosis, and dis …
Progressive Loss of Donor-Reactive CD4(+) Effector Memory T Cells due to Apoptosis Underlies Donor-Specific Hyporesponsiveness in Stable Renal Transplant Recipients.
van der List ACJ, Litjens NHR, Klepper M, Prevoo F, Betjes MGH. van der List ACJ, et al. J Immunol. 2022 Oct 1;209(7):1389-1400. doi: 10.4049/jimmunol.2200352. Epub 2022 Sep 2. J Immunol. 2022. PMID: 36165198
Results demonstrated a decline in CD4(+) donor-reactive T cells within the first 3-5 y after transplantation. ...This decline was strongly correlated with reduced proliferation of CD4(+) T cells to donor Ag. The donor-reactive CD8(+) T …
Results demonstrated a decline in CD4(+) donor-reactive T cells within the first 3-5 y after transplantation. ...This d …
Induction of apoptosis in CD4(+) T-cells is linked with optimal treatment response in patients with relapsing-remitting multiple sclerosis treated with Glatiramer acetate.
Boziki M, Lagoudaki R, Melo P, Kanidou F, Bakirtzis C, Nikolaidis I, Grigoriadou E, Afrantou T, Tatsi T, Matsi S, Grigoriadis N. Boziki M, et al. J Neurol Sci. 2019 Jun 15;401:43-50. doi: 10.1016/j.jns.2019.03.030. Epub 2019 Mar 29. J Neurol Sci. 2019. PMID: 31009931
Eighteen patients (8 patients under GA and 10 patients under IFNbeta were additionally evaluated at a 12-month follow-up and were relapse- and radiological activity-free. For these patients, apoptosis was also evaluated by molecular techniques. RESULTS: At inclusion, optim …
Eighteen patients (8 patients under GA and 10 patients under IFNbeta were additionally evaluated at a 12-month follow-up and were relapse- a …
MiR-let-7i inhibits CD4+ T cell apoptosis in patients with acute coronary syndrome.
Zhao B, Zhang Z, Gui L, Xiang Y, Sun X, Huang L. Zhao B, et al. Adv Clin Exp Med. 2021 Aug;30(8):779-788. doi: 10.17219/acem/135937. Adv Clin Exp Med. 2021. PMID: 34313407 Free article.
Studies have confirmed that CD4+ T cells are resistant to apoptosis, but the specific mechanism has not been elucidated yet. ...RESULTS: Apoptosis of CD4+ T cells in ACS patients was significantly decreased. ...
Studies have confirmed that CD4+ T cells are resistant to apoptosis, but the specific mechanism has not been elu …
An exacerbated metabolism and mitochondrial reactive oxygen species contribute to mitochondrial alterations and apoptosis in CD4 T cells during the acute phase of Trypanosoma cruzi infection.
Ana Y, Rojas Marquez JD, Fozzatti L, Baigorrí RE, Marin C, Maletto BA, Cerbán FM, Radi R, Piacenza L, Stempin CC. Ana Y, et al. Free Radic Biol Med. 2021 Feb 1;163:268-280. doi: 10.1016/j.freeradbiomed.2020.12.009. Epub 2020 Dec 28. Free Radic Biol Med. 2021. PMID: 33359261
In addition, CD4 T cells with mitochondrial alteration displayed an activated phenotype, and were less functional and more prone to apoptosis. ...Remarkably, the apoptosis observed in CD4 T cells with MMP depolarization was …
In addition, CD4 T cells with mitochondrial alteration displayed an activated phenotype, and were less functional and m …
8,979 results