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2010 4
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Page 1
Modeling host responses in ferrets during A/California/07/2009 influenza infection.
Rowe T, León AJ, Crevar CJ, Carter DM, Xu L, Ran L, Fang Y, Cameron CM, Cameron MJ, Banner D, Ng DC, Ran R, Weirback HK, Wiley CA, Kelvin DJ, Ross TM. Rowe T, et al. Virology. 2010 Jun 5;401(2):257-65. doi: 10.1016/j.virol.2010.02.020. Epub 2010 Mar 23. Virology. 2010. PMID: 20334888 Free PMC article.
Chemokines CCL2, CCL8, CXCL7 and CXCL10 along with the majority of interferon-stimulated genes were expressed early, correlated to lung pathology, and abruptly decreased expression on day 7 following infection of A/California/07/2009. Interestingly, the drop in innate immu …
Chemokines CCL2, CCL8, CXCL7 and CXCL10 along with the majority of interferon-stimulated genes were expressed early, correlated to lu …
Deficiency of eIF4B Increases Mouse Mortality and Impairs Antiviral Immunity.
Chen B, Chen Y, Rai KR, Wang X, Liu S, Li Y, Xiao M, Ma Y, Wang G, Guo G, Huang S, Chen JL. Chen B, et al. Front Immunol. 2021 Sep 10;12:723885. doi: 10.3389/fimmu.2021.723885. eCollection 2021. Front Immunol. 2021. PMID: 34566982 Free PMC article.
Selective deletion of eIF4B in lung epithelium also markedly promoted replication of influenza A virus (IAV) in the lung of infected animals. Furthermore, we observed that eIF4B deficiency significantly enhanced the expression of several important inflammation-associated f …
Selective deletion of eIF4B in lung epithelium also markedly promoted replication of influenza A virus (IAV) in the lung of infected …
The PA-interacting host protein nucleolin acts as an antiviral factor during highly pathogenic H5N1 avian influenza virus infection.
Gao Z, Hu J, Wang X, Yang Q, Liang Y, Ma C, Liu D, Liu K, Hao X, Gu M, Liu X, Jiao XA, Liu X. Gao Z, et al. Arch Virol. 2018 Oct;163(10):2775-2786. doi: 10.1007/s00705-018-3926-3. Epub 2018 Jul 5. Arch Virol. 2018. PMID: 29974255
Polymerase acidic (PA) protein is a multifunctional regulator of influenza A virus (IAV) replication and pathogenesis. In a previous study, we reported that nucleolin (NCL) is a novel PA-interacting host protein. ...Further studies exploring the antiviral mechanisms of NCL …
Polymerase acidic (PA) protein is a multifunctional regulator of influenza A virus (IAV) replication and pathogenesis. In a previous …
Coronavirus: a shift in focus away from IFN response and towards other inflammatory targets.
Thoutam A, Breitzig M, Lockey R, Kolliputi N. Thoutam A, et al. J Cell Commun Signal. 2020 Sep 7:1-2. doi: 10.1007/s12079-020-00574-3. Online ahead of print. J Cell Commun Signal. 2020. PMID: 32922564 Free article.
To better understand the biology of COVID-19, an initial barrage of studies compared SARS-CoV-2 to other respiratory viruses: MERS-CoV, SARS-CoV-1, human parainfluenza virus 3 (HPIV3), respiratory syncytial virus (RSV), and Influenza A Virus (IAV). These studies ind …
To better understand the biology of COVID-19, an initial barrage of studies compared SARS-CoV-2 to other respiratory viruses: MERS-CoV, SARS …
Coronavirus: a shift in focus away from IFN response and towards other inflammatory targets.
Thoutam A, Breitzig M, Lockey R, Kolliputi N. Thoutam A, et al. J Cell Commun Signal. 2020 Dec;14(4):469-470. doi: 10.1007/s12079-020-00574-3. Epub 2020 Sep 7. J Cell Commun Signal. 2020. PMID: 32895779 Free PMC article.
To better understand the biology of COVID-19, an initial barrage of studies compared SARS-CoV-2 to other respiratory viruses: MERS-CoV, SARS-CoV-1, human parainfluenza virus 3 (HPIV3), respiratory syncytial virus (RSV), and Influenza A Virus (IAV). These studies ind …
To better understand the biology of COVID-19, an initial barrage of studies compared SARS-CoV-2 to other respiratory viruses: MERS-CoV, SARS …
Suppression of innate immune pathology by regulatory T cells during Influenza A virus infection of immunodeficient mice.
Antunes I, Kassiotis G. Antunes I, et al. J Virol. 2010 Dec;84(24):12564-75. doi: 10.1128/JVI.01559-10. Epub 2010 Oct 13. J Virol. 2010. PMID: 20943986 Free PMC article.
Here, we have examined the potential involvement of regulatory T (Treg) cells in limiting pathology induced by influenza A virus (IAV) infection. Using lymphocyte-deficient mice as hosts, we showed that Treg cell reconstitution resulted in a significant delay in weight los …
Here, we have examined the potential involvement of regulatory T (Treg) cells in limiting pathology induced by influenza A virus (IAV …
Plasticity and virus specificity of the airway epithelial cell immune response during respiratory virus infection.
Ioannidis I, McNally B, Willette M, Peeples ME, Chaussabel D, Durbin JE, Ramilo O, Mejias A, Flaño E. Ioannidis I, et al. J Virol. 2012 May;86(10):5422-36. doi: 10.1128/JVI.06757-11. Epub 2012 Mar 7. J Virol. 2012. PMID: 22398282 Free PMC article.
Here, using oligonucleotide and protein arrays, we analyze the infection of primary polarized human AEC cultures with influenza virus and respiratory syncytial virus (RSV), and we show that the immune response of AECs is quantitatively and qualitatively virus specif …
Here, using oligonucleotide and protein arrays, we analyze the infection of primary polarized human AEC cultures with influenza …
The differential activity of interferon-α subtypes is consistent among distinct target genes and cell types.
Moll HP, Maier T, Zommer A, Lavoie T, Brostjan C. Moll HP, et al. Cytokine. 2011 Jan;53(1):52-9. doi: 10.1016/j.cyto.2010.09.006. Epub 2010 Oct 12. Cytokine. 2011. PMID: 20943413 Free PMC article.
The cellular response was evaluated for 13 distinct IFN-alpha proteins with respect to transcript regulation of the IFN-stimulated genes (ISGs) IFIT1, ISG15, CXCL10, CXCL11 and CCL8. The IFN-alpha proteins displayed a remarkably consistent potency in gene induction irrespe …
The cellular response was evaluated for 13 distinct IFN-alpha proteins with respect to transcript regulation of the IFN-stimulated genes (IS …
Spiral ligament fibrocyte-derived MCP-1/CCL2 contributes to inner ear inflammation secondary to nontypeable H. influenzae-induced otitis media.
Woo JI, Pan H, Oh S, Lim DJ, Moon SK. Woo JI, et al. BMC Infect Dis. 2010 Oct 28;10:314. doi: 10.1186/1471-2334-10-314. BMC Infect Dis. 2010. PMID: 21029462 Free PMC article.
We demonstrated that targeting MCP-1/CCL2 enhances NTHI-induced up-regulation of MCP-2/CCL8 in SLFs and up-regulates the basal expression of CCR2 in the splenocytes. ...
We demonstrated that targeting MCP-1/CCL2 enhances NTHI-induced up-regulation of MCP-2/CCL8 in SLFs and up-regulates the basal expres …