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HIV-1 infection of microglial cells in a reconstituted humanized mouse model and identification of compounds that selectively reverse HIV latency.

Llewellyn GN, Alvarez-Carbonell D, Chateau M, Karn J, Cannon PM.

J Neurovirol. 2018 Apr;24(2):192-203. doi: 10.1007/s13365-017-0604-2. Epub 2017 Dec 18.


Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency.

Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, Ernst A, Ng TF, Cho T, Cannon PM, Sidhu SS, Sicheri F, Durocher D.

Nat Biotechnol. 2018 Jan;36(1):95-102. doi: 10.1038/nbt.4021. Epub 2017 Nov 27.


Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases.

Rogers GL, Cannon PM.

Hematol Oncol Clin North Am. 2017 Oct;31(5):883-895. doi: 10.1016/j.hoc.2017.06.008. Review.


Spatiotemporally restricted arenavirus replication induces immune surveillance and type I interferon-dependent tumour regression.

Kalkavan H, Sharma P, Kasper S, Helfrich I, Pandyra AA, Gassa A, Virchow I, Flatz L, Brandenburg T, Namineni S, Heikenwalder M, Höchst B, Knolle PA, Wollmann G, von Laer D, Drexler I, Rathbun J, Cannon PM, Scheu S, Bauer J, Chauhan J, Häussinger D, Willimsky G, Löhning M, Schadendorf D, Brandau S, Schuler M, Lang PA, Lang KS.

Nat Commun. 2017 Mar 1;8:14447. doi: 10.1038/ncomms14447.


Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells.

DiGiusto DL, Cannon PM, Holmes MC, Li L, Rao A, Wang J, Lee G, Gregory PD, Kim KA, Hayward SB, Meyer K, Exline C, Lopez E, Henley J, Gonzalez N, Bedell V, Stan R, Zaia JA.

Mol Ther Methods Clin Dev. 2016 Nov 9;3:16067. eCollection 2016.


Clinical Applications of Genome Editing to HIV Cure.

Wang CX, Cannon PM.

AIDS Patient Care STDS. 2016 Dec;30(12):539-544. Epub 2016 Nov 17.


A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

Lederman MM, Cannon PM, Currier JS, June CH, Kiem HP, Kuritzkes DR, Lewin SR, Margolis DM, McCune JM, Mellors JW, Schacker TW, Sekaly RP, Tebas P, Walker BD, Douek DC.

Pathog Immun. 2016 Spring;1(1):154-164.


Human Immunodeficiency Virus Immune Cell Receptors, Coreceptors, and Cofactors: Implications for Prevention and Treatment.

Woodham AW, Skeate JG, Sanna AM, Taylor JR, Da Silva DM, Cannon PM, Kast WM.

AIDS Patient Care STDS. 2016 Jul;30(7):291-306. doi: 10.1089/apc.2016.0100. Review.


The clinical applications of genome editing in HIV.

Wang CX, Cannon PM.

Blood. 2016 May 26;127(21):2546-52. doi: 10.1182/blood-2016-01-678144. Epub 2016 Apr 6. Review.


Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.

Wang J, Exline CM, DeClercq JJ, Llewellyn GN, Hayward SB, Li PW, Shivak DA, Surosky RT, Gregory PD, Holmes MC, Cannon PM.

Nat Biotechnol. 2015 Dec;33(12):1256-1263. doi: 10.1038/nbt.3408. Epub 2015 Nov 9.


Determinants in HIV-2 Env and tetherin required for functional interaction.

Exline CM, Yang SJ, Haworth KG, Rengarajan S, Lopez LA, Droniou ME, Seclen E, Cannon PM.

Retrovirology. 2015 Aug 7;12:67. doi: 10.1186/s12977-015-0194-0.


Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.

Rathbun JY, Droniou ME, Damoiseaux R, Haworth KG, Henley JE, Exline CM, Choe H, Cannon PM.

J Virol. 2015 Aug;89(16):8428-43. doi: 10.1128/JVI.00997-15. Epub 2015 Jun 3.


Genome editing technologies: defining a path to clinic.

Corrigan-Curay J, O'Reilly M, Kohn DB, Cannon PM, Bao G, Bushman FD, Carroll D, Cathomen T, Joung JK, Roth D, Sadelain M, Scharenberg AM, von Kalle C, Zhang F, Jambou R, Rosenthal E, Hassani M, Singh A, Porteus MH.

Mol Ther. 2015 May;23(5):796-806. doi: 10.1038/mt.2015.54. No abstract available.


AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.

Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES Jr, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M Jr, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M.

Nature. 2015 Mar 5;519(7541):87-91. doi: 10.1038/nature14264. Epub 2015 Feb 18.


HIV eradication--from Berlin to Boston.

Cannon PM, Kohn DB, Kiem HP.

Nat Biotechnol. 2014 Apr;32(4):315-6. doi: 10.1038/nbt.2868. No abstract available.


Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice.

Hofer U, Henley JE, Exline CM, Mulhern O, Lopez E, Cannon PM.

J Infect Dis. 2013 Nov;208 Suppl 2:S160-4. doi: 10.1093/infdis/jit382. Review.


Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases.

Li L, Krymskaya L, Wang J, Henley J, Rao A, Cao LF, Tran CA, Torres-Coronado M, Gardner A, Gonzalez N, Kim K, Liu PQ, Hofer U, Lopez E, Gregory PD, Liu Q, Holmes MC, Cannon PM, Zaia JA, DiGiusto DL.

Mol Ther. 2013 Jun;21(6):1259-69. doi: 10.1038/mt.2013.65. Epub 2013 Apr 16.


A systems biology starter kit for arenaviruses.

Droniou-Bonzom ME, Cannon PM.

Viruses. 2012 Dec;4(12):3625-46. Review.


Anti-tetherin activities of HIV-1 Vpu and Ebola virus glycoprotein do not involve removal of tetherin from lipid rafts.

Lopez LA, Yang SJ, Exline CM, Rengarajan S, Haworth KG, Cannon PM.

J Virol. 2012 May;86(10):5467-80. doi: 10.1128/JVI.06280-11. Epub 2012 Mar 7.


Substitutions in the glycoprotein (GP) of the Candid#1 vaccine strain of Junin virus increase dependence on human transferrin receptor 1 for entry and destabilize the metastable conformation of GP.

Droniou-Bonzom ME, Reignier T, Oldenburg JE, Cox AU, Exline CM, Rathbun JY, Cannon PM.

J Virol. 2011 Dec;85(24):13457-62. doi: 10.1128/JVI.05616-11. Epub 2011 Oct 5.

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