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Items: 1 to 20 of 51

1.

Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity.

Woodford MR, Hughes M, Sager RA, Backe SJ, Baker-Williams AJ, Bratslavsky MS, Jacob JM, Shapiro O, Wong M, Bratslavsky G, Bourboulia D, Mollapour M.

Oncotarget. 2019 Oct 8;10(56):5824-5834. doi: 10.18632/oncotarget.27217. eCollection 2019 Oct 8.

2.

Co-chaperones TIMP2 and AHA1 Competitively Regulate Extracellular HSP90:Client MMP2 Activity and Matrix Proteolysis.

Baker-Williams AJ, Hashmi F, Budzyński MA, Woodford MR, Gleicher S, Himanen SV, Makedon AM, Friedman D, Cortes S, Namek S, Stetler-Stevenson WG, Bratslavsky G, Bah A, Mollapour M, Sistonen L, Bourboulia D.

Cell Rep. 2019 Aug 13;28(7):1894-1906.e6. doi: 10.1016/j.celrep.2019.07.045.

3.

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90.

Sager RA, Woodford MR, Backe SJ, Makedon AM, Baker-Williams AJ, DiGregorio BT, Loiselle DR, Haystead TA, Zachara NE, Prodromou C, Bourboulia D, Schmidt LS, Linehan WM, Bratslavsky G, Mollapour M.

Cell Rep. 2019 Jan 29;26(5):1344-1356.e5. doi: 10.1016/j.celrep.2019.01.018.

4.

Extracellular Phosphorylation of TIMP-2 by Secreted c-Src Tyrosine Kinase Controls MMP-2 Activity.

Sánchez-Pozo J, Baker-Williams AJ, Woodford MR, Bullard R, Wei B, Mollapour M, Stetler-Stevenson WG, Bratslavsky G, Bourboulia D.

iScience. 2018 Mar 23;1:87-96. doi: 10.1016/j.isci.2018.02.004. Epub 2018 Mar 23.

5.

Detection and Analysis of Extracellular Hsp90 (eHsp90).

Cortes S, Baker-Williams AJ, Mollapour M, Bourboulia D.

Methods Mol Biol. 2018;1709:321-329. doi: 10.1007/978-1-4939-7477-1_23.

PMID:
29177669
6.

Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

Dushukyan N, Dunn DM, Sager RA, Woodford MR, Loiselle DR, Daneshvar M, Baker-Williams AJ, Chisholm JD, Truman AW, Vaughan CK, Haystead TA, Bratslavsky G, Bourboulia D, Mollapour M.

Cell Rep. 2017 Nov 14;21(7):1883-1895. doi: 10.1016/j.celrep.2017.10.074.

7.

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M.

EMBO J. 2017 Dec 15;36(24):3650-3665. doi: 10.15252/embj.201796700. Epub 2017 Nov 10.

8.

Structural and functional basis of protein phosphatase 5 substrate specificity.

Oberoi J, Dunn DM, Woodford MR, Mariotti L, Schulman J, Bourboulia D, Mollapour M, Vaughan CK.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):9009-14. doi: 10.1073/pnas.1603059113. Epub 2016 Jul 27.

9.

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D, Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W, Bratslavsky G, Mollapour M.

Nat Commun. 2016 Jun 29;7:12037. doi: 10.1038/ncomms12037.

10.

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.

Woodford MR, Truman AW, Dunn DM, Jensen SM, Cotran R, Bullard R, Abouelleil M, Beebe K, Wolfgeher D, Wierzbicki S, Post DE, Caza T, Tsutsumi S, Panaretou B, Kron SJ, Trepel JB, Landas S, Prodromou C, Shapiro O, Stetler-Stevenson WG, Bourboulia D, Neckers L, Bratslavsky G, Mollapour M.

Cell Rep. 2016 Feb 2;14(4):872-884. doi: 10.1016/j.celrep.2015.12.084. Epub 2016 Jan 21.

11.

The dynamic interactome of human Aha1 upon Y223 phosphorylation.

Wolfgeher D, Dunn DM, Woodford MR, Bourboulia D, Bratslavsky G, Mollapour M, Kron SJ, Truman AW.

Data Brief. 2015 Nov 6;5:752-5. doi: 10.1016/j.dib.2015.10.028. eCollection 2015 Dec.

12.

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells.

Dunn DM, Woodford MR, Truman AW, Jensen SM, Schulman J, Caza T, Remillard TC, Loiselle D, Wolfgeher D, Blagg BS, Franco L, Haystead TA, Daturpalli S, Mayer MP, Trepel JB, Morgan RM, Prodromou C, Kron SJ, Panaretou B, Stetler-Stevenson WG, Landas SK, Neckers L, Bratslavsky G, Bourboulia D, Mollapour M.

Cell Rep. 2015 Aug 11;12(6):1006-18. doi: 10.1016/j.celrep.2015.07.004. Epub 2015 Jul 30.

13.

Targeting Hsp90 in urothelial carcinoma.

Chehab M, Caza T, Skotnicki K, Landas S, Bratslavsky G, Mollapour M, Bourboulia D.

Oncotarget. 2015 Apr 20;6(11):8454-73. Review.

14.

Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors.

Mollapour M, Bourboulia D, Beebe K, Woodford MR, Polier S, Hoang A, Chelluri R, Li Y, Guo A, Lee MJ, Fotooh-Abadi E, Khan S, Prince T, Miyajima N, Yoshida S, Tsutsumi S, Xu W, Panaretou B, Stetler-Stevenson WG, Bratslavsky G, Trepel JB, Prodromou C, Neckers L.

Mol Cell. 2014 Jan 23;53(2):317-29. doi: 10.1016/j.molcel.2013.12.007.

15.

Molecular mechanisms of tissue inhibitor of metalloproteinase 2 in the tumor microenvironment.

Remillard TC, Bratslavsky G, Jensen-Taubman S, Stetler-Stevenson WG, Bourboulia D.

Mol Cell Ther. 2014 Jun 3;2:17. doi: 10.1186/2052-8426-2-17. eCollection 2014. Review.

16.

Contributions of co-chaperones and post-translational modifications towards Hsp90 drug sensitivity.

Walton-Diaz A, Khan S, Bourboulia D, Trepel JB, Neckers L, Mollapour M.

Future Med Chem. 2013 Jun;5(9):1059-71. doi: 10.4155/fmc.13.88. Review.

PMID:
23734688
17.

An endogenous inhibitor of angiogenesis inversely correlates with side population phenotype and function in human lung cancer cells.

Han H, Bourboulia D, Jensen-Taubman S, Isaac B, Wei B, Stetler-Stevenson WG.

Oncogene. 2014 Feb 27;33(9):1198-206. doi: 10.1038/onc.2013.61. Epub 2013 Mar 11.

18.

TIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cells.

Bourboulia D, Han H, Jensen-Taubman S, Gavil N, Isaac B, Wei B, Neckers L, Stetler-Stevenson WG.

Oncotarget. 2013 Jan;4(1):166-76.

19.

Combined inhibition of Wee1 and Hsp90 activates intrinsic apoptosis in cancer cells.

Iwai A, Bourboulia D, Mollapour M, Jensen-Taubman S, Lee S, Donnelly AC, Yoshida S, Miyajima N, Tsutsumi S, Smith AK, Sun D, Wu X, Blagg BS, Trepel JB, Stetler-Stevenson WG, Neckers L.

Cell Cycle. 2012 Oct 1;11(19):3649-55. doi: 10.4161/cc.21926. Epub 2012 Aug 30.

20.

TIMP-2 targets tumor-associated myeloid suppressor cells with effects in cancer immune dysfunction and angiogenesis.

Guedez L, Jensen-Taubman S, Bourboulia D, Kwityn CJ, Wei B, Caterina J, Stetler-Stevenson WG.

J Immunother. 2012 Jul;35(6):502-12. doi: 10.1097/CJI.0b013e3182619c8e.

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