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Exp Gerontol. 2017 Aug;94:4-8. doi: 10.1016/j.exger.2017.01.027. Epub 2017 Feb 2.

Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.

Author information

1
Research Service, James A. Haley Veterans Administration Hospital, 13000 Bruce B Downs Blvd, Tampa, FL, United States; Center of Excellence for Aging and Brain Repair, Dept. of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, United States. Electronic address: pbickfor@health.usf.edu.
2
Center of Excellence for Aging and Brain Repair, Dept. of Neurosurgery and Brain Repair, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.

Abstract

Aging is the primary risk factor for many neurodegenerative diseases. Thus, understanding the basic biological changes that take place with aging that lead to the brain being less resilient to disease progression of neurodegenerative diseases such as Parkinson's disease or Alzheimer's disease or insults to the brain such as stroke or traumatic brain injuries. Clearly this will not cure the disease per se, yet increasing the ability of the brain to respond to injury could improve long term outcomes. The focus of this review is examining changes in microglia with age and possible therapeutic interventions involving the use of polyphenol rich dietary supplements.

KEYWORDS:

Microglia; Polyphenol

PMID:
28163132
PMCID:
PMC5469713
DOI:
10.1016/j.exger.2017.01.027
[Indexed for MEDLINE]
Free PMC Article

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