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Items: 1 to 20 of 32


Amyloid-β Inhibits PDGFβ Receptor Activation and Prevents PDGF-BBInduced Neuroprotection.

Liu H, Saffi GT, Vasefi MS, Choi Y, Kruk JS, Ahmed N, Gondora N, Mielke J, Leonenko Z, Beazely MA.

Curr Alzheimer Res. 2018;15(7):618-627. doi: 10.2174/1567205015666180110110321.


Fitting naloxone into community pharmacy practice.

Grindrod K, Beazely M.

Can Pharm J (Ott). 2016 Nov;149(6):329-331. Epub 2016 Oct 6. No abstract available.


Structure-activity relationship studies of benzyl-, phenethyl-, and pyridyl-substituted tetrahydroacridin-9-amines as multitargeting agents to treat Alzheimer's disease.

Osman W, Mohamed T, Sit VM, Vasefi MS, Beazely MA, Rao PP.

Chem Biol Drug Des. 2016 Nov;88(5):710-723. doi: 10.1111/cbdd.12800. Epub 2016 Jul 11.


Data on acylglycerophosphate acyltransferase 4 (AGPAT4) during murine embryogenesis and in embryo-derived cultured primary neurons and glia.

Bradley RM, Mardian EB, Marvyn PM, Vasefi MS, Beazely MA, Mielke JG, Duncan RE.

Data Brief. 2015 Nov 24;6:28-32. doi: 10.1016/j.dib.2015.11.033. eCollection 2016 Mar.


Fluoxetine-induced transactivation of the platelet-derived growth factor type β receptor reveals a novel heterologous desensitization process.

Kruk JS, Vasefi MS, Gondora N, Ahmed N, Heikkila JJ, Beazely MA.

Mol Cell Neurosci. 2015 Mar;65:45-51. doi: 10.1016/j.mcn.2015.02.013. Epub 2015 Feb 19.


5-HT7 receptor activation promotes an increase in TrkB receptor expression and phosphorylation.

Samarajeewa A, Goldemann L, Vasefi MS, Ahmed N, Gondora N, Khanderia C, Mielke JG, Beazely MA.

Front Behav Neurosci. 2014 Nov 7;8:391. doi: 10.3389/fnbeh.2014.00391. eCollection 2014.


Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: towards non-invasive glaucoma gene therapy.

Alqawlaq S, Sivak JM, Huzil JT, Ivanova MV, Flanagan JG, Beazely MA, Foldvari M.

Nanomedicine. 2014 Nov;10(8):1637-47. doi: 10.1016/j.nano.2014.05.010. Epub 2014 Jun 4.


Reactive oxygen species are required for 5-HT-induced transactivation of neuronal platelet-derived growth factor and TrkB receptors, but not for ERK1/2 activation.

Kruk JS, Vasefi MS, Heikkila JJ, Beazely MA.

PLoS One. 2013 Sep 27;8(9):e77027. doi: 10.1371/journal.pone.0077027. eCollection 2013.


Acute 5-HT7 receptor activation increases NMDA-evoked currents and differentially alters NMDA receptor subunit phosphorylation and trafficking in hippocampal neurons.

Vasefi MS, Yang K, Li J, Kruk JS, Heikkila JJ, Jackson MF, MacDonald JF, Beazely MA.

Mol Brain. 2013 May 14;6:24. doi: 10.1186/1756-6606-6-24.


5-Hydroxytryptamine type 7 receptor neuroprotection against NMDA-induced excitotoxicity is PDGFβ receptor dependent.

Vasefi MS, Kruk JS, Heikkila JJ, Beazely MA.

J Neurochem. 2013 Apr;125(1):26-36. doi: 10.1111/jnc.12157. Epub 2013 Feb 13.


5-HT(1A) receptors transactivate the platelet-derived growth factor receptor type beta in neuronal cells.

Kruk JS, Vasefi MS, Liu H, Heikkila JJ, Beazely MA.

Cell Signal. 2013 Jan;25(1):133-43. doi: 10.1016/j.cellsig.2012.09.021. Epub 2012 Sep 21.


Development and evaluation of multifunctional agents for potential treatment of Alzheimer's disease: application to a pyrimidine-2,4-diamine template.

Mohamed T, Yeung JC, Vasefi MS, Beazely MA, Rao PP.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4707-12. doi: 10.1016/j.bmcl.2012.05.077. Epub 2012 May 26.


Activation of 5-HT7 receptors increases neuronal platelet-derived growth factor β receptor expression.

Vasefi MS, Kruk JS, Liu H, Heikkila JJ, Beazely MA.

Neurosci Lett. 2012 Mar 9;511(2):65-9. doi: 10.1016/j.neulet.2012.01.016. Epub 2012 Jan 20.


Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1.

Peng F, Yao H, Bai X, Zhu X, Reiner BC, Beazely M, Funa K, Xiong H, Buch S.

J Biol Chem. 2010 Jul 9;285(28):21615-24. doi: 10.1074/jbc.M110.107003. Epub 2010 May 7.


Postsynaptic clustering and activation of Pyk2 by PSD-95.

Bartos JA, Ulrich JD, Li H, Beazely MA, Chen Y, Macdonald JF, Hell JW.

J Neurosci. 2010 Jan 13;30(2):449-63. doi: 10.1523/JNEUROSCI.4992-08.2010.


Vasoactive intestinal peptide acts via multiple signal pathways to regulate hippocampal NMDA receptors and synaptic transmission.

Yang K, Trepanier CH, Li H, Beazely MA, Lerner EA, Jackson MF, MacDonald JF.

Hippocampus. 2009 Sep;19(9):779-89. doi: 10.1002/hipo.20559.


Platelet-derived growth factor selectively inhibits NR2B-containing N-methyl-D-aspartate receptors in CA1 hippocampal neurons.

Beazely MA, Lim A, Li H, Trepanier C, Chen X, Sidhu B, Macdonald JF.

J Biol Chem. 2009 Mar 20;284(12):8054-63. doi: 10.1074/jbc.M805384200. Epub 2008 Dec 23.


Abelson tyrosine kinase links PDGFbeta receptor activation to cytoskeletal regulation of NMDA receptors in CA1 hippocampal neurons.

Beazely MA, Weerapura M, MacDonald JF.

Mol Brain. 2008 Dec 12;1:20. doi: 10.1186/1756-6606-1-20.


Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.

Thompson RJ, Jackson MF, Olah ME, Rungta RL, Hines DJ, Beazely MA, MacDonald JF, MacVicar BA.

Science. 2008 Dec 5;322(5907):1555-9. doi: 10.1126/science.1165209.


Hippocampal long-term synaptic plasticity and signal amplification of NMDA receptors.

MacDonald JF, Jackson MF, Beazely MA.

Crit Rev Neurobiol. 2006;18(1-2):71-84. Review.


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