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Items: 1 to 20 of 145

1.

N-Terminal Truncated Aβ4 - 42 Is a Substrate for Neprilysin Degradation in vitro and in vivo.

Hornung K, Zampar S, Engel N, Klafki H, Liepold T, Bayer TA, Wiltfang J, Jahn O, Wirths O.

J Alzheimers Dis. 2019 Jan 14. doi: 10.3233/JAD-181134. [Epub ahead of print]

PMID:
30664509
2.

SUMO1-conjugation is altered during normal aging but not by increased amyloid burden.

Stankova T, Piepkorn L, Bayer TA, Jahn O, Tirard M.

Aging Cell. 2018 Apr 6:e12760. doi: 10.1111/acel.12760. [Epub ahead of print]

3.

Synergistic Effect on Neurodegeneration by N-Truncated Aβ4-42 and Pyroglutamate Aβ3-42 in a Mouse Model of Alzheimer's Disease.

Lopez-Noguerola JS, Giessen NME, Ueberück M, Meißner JN, Pelgrim CE, Adams J, Wirths O, Bouter Y, Bayer TA.

Front Aging Neurosci. 2018 Mar 8;10:64. doi: 10.3389/fnagi.2018.00064. eCollection 2018.

4.

Synaptic Alterations in Mouse Models for Alzheimer Disease-A Special Focus on N-Truncated Abeta 4-42.

Dietrich K, Bouter Y, Müller M, Bayer TA.

Molecules. 2018 Mar 21;23(4). pii: E718. doi: 10.3390/molecules23040718. Review.

5.

Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age.

Ramos-Miguel A, Jones AA, Sawada K, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG.

Neurobiol Dis. 2018 Jun;114:31-44. doi: 10.1016/j.nbd.2018.02.006. Epub 2018 Feb 26.

PMID:
29496544
6.

N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models.

Wirths O, Walter S, Kraus I, Klafki HW, Stazi M, Oberstein TJ, Ghiso J, Wiltfang J, Bayer TA, Weggen S.

Alzheimers Res Ther. 2017 Oct 4;9(1):80. doi: 10.1186/s13195-017-0309-z.

7.

Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer's disease.

Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF.

Part Fibre Toxicol. 2017 Aug 30;14(1):35. doi: 10.1186/s12989-017-0213-5.

8.

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease.

Yin Z, Raj D, Saiepour N, Van Dam D, Brouwer N, Holtman IR, Eggen BJL, Möller T, Tamm JA, Abdourahman A, Hol EM, Kamphuis W, Bayer TA, De Deyn PP, Boddeke E.

Neurobiol Aging. 2017 Jul;55:115-122. doi: 10.1016/j.neurobiolaging.2017.03.021. Epub 2017 Mar 27.

PMID:
28434692
9.

Decreased cortical FADD protein is associated with clinical dementia and cognitive decline in an elderly community sample.

Ramos-Miguel A, García-Sevilla JA, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG, García-Fuster MJ.

Mol Neurodegener. 2017 Mar 20;12(1):26. doi: 10.1186/s13024-017-0168-x.

10.

Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs.

Jakobsen JE, Johansen MG, Schmidt M, Liu Y, Li R, Callesen H, Melnikova M, Habekost M, Matrone C, Bouter Y, Bayer TA, Nielsen AL, Duthie M, Fraser PE, Holm IE, Jørgensen AL.

J Alzheimers Dis. 2016 Jul 14;53(4):1617-30. doi: 10.3233/JAD-160408.

PMID:
27540966
11.

Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models.

Reinert J, Richard BC, Klafki HW, Friedrich B, Bayer TA, Wiltfang J, Kovacs GG, Ingelsson M, Lannfelt L, Paetau A, Bergquist J, Wirths O.

Acta Neuropathol Commun. 2016 Mar 8;4:24. doi: 10.1186/s40478-016-0294-7.

12.

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

Kumar S, Wirths O, Stüber K, Wunderlich P, Koch P, Theil S, Rezaei-Ghaleh N, Zweckstetter M, Bayer TA, Brüstle O, Thal DR, Walter J.

Acta Neuropathol. 2016 Apr;131(4):525-37. doi: 10.1007/s00401-016-1546-0. Epub 2016 Feb 22.

13.

Gene Expression Profiling in the APP/PS1KI Mouse Model of Familial Alzheimer's Disease.

Weissmann R, Hüttenrauch M, Kacprowski T, Bouter Y, Pradier L, Bayer TA, Kuss AW, Wirths O.

J Alzheimers Dis. 2016;50(2):397-409. doi: 10.3233/JAD-150745.

PMID:
26639971
14.

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample.

Ramos-Miguel A, Hercher C, Beasley CL, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG.

Mol Neurodegener. 2015 Dec 2;10:65. doi: 10.1186/s13024-015-0061-4.

15.

Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X.

Antonios G, Borgers H, Richard BC, Brauß A, Meißner J, Weggen S, Pena V, Pillot T, Davies SL, Bakrania P, Matthews D, Brownlees J, Bouter Y, Bayer TA.

Sci Rep. 2015 Dec 2;5:17338. doi: 10.1038/srep17338.

16.

Endothelial LRP1 transports amyloid-β(1-42) across the blood-brain barrier.

Storck SE, Meister S, Nahrath J, Meißner JN, Schubert N, Di Spiezio A, Baches S, Vandenbroucke RE, Bouter Y, Prikulis I, Korth C, Weggen S, Heimann A, Schwaninger M, Bayer TA, Pietrzik CU.

J Clin Invest. 2016 Jan;126(1):123-36. doi: 10.1172/JCI81108. Epub 2015 Nov 30.

17.

N-truncated Aβ2-X starting with position two in sporadic Alzheimer's disease cases and two Alzheimer mouse models.

Savastano A, Klafki H, Haußmann U, Oberstein TJ, Muller P, Wirths O, Wiltfang J, Bayer TA.

J Alzheimers Dis. 2016;49(1):101-10. doi: 10.3233/JAD-150394.

PMID:
26529393
18.

Abeta targets of the biosimilar antibodies of Bapineuzumab, Crenezumab, Solanezumab in comparison to an antibody against N‑truncated Abeta in sporadic Alzheimer disease cases and mouse models.

Bouter Y, Lopez Noguerola JS, Tucholla P, Crespi GA, Parker MW, Wiltfang J, Miles LA, Bayer TA.

Acta Neuropathol. 2015 Nov;130(5):713-29.

PMID:
26467270
19.

N-Truncated Aβ 2-X Starting with Position Two in Sporadic Alzheimer's Disease Cases and Two Alzheimer Mouse Models.

Savastano A, Klafki H, Haußmann U, Oberstein TJ, Muller P, Wirths O, Wiltfang J, Bayer TA.

J Alzheimers Dis. 2015 Sep 24. [Epub ahead of print]

PMID:
26444772
20.

Super-Resolution Microscopy of Cerebrospinal Fluid Biomarkers as a Tool for Alzheimer's Disease Diagnostics.

Zhang WI, Antonios G, Rabano A, Bayer TA, Schneider A, Rizzoli SO.

J Alzheimers Dis. 2015;46(4):1007-20. doi: 10.3233/JAD-150064.

PMID:
25881910

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