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Items: 1 to 20 of 80

1.

Clinical and immunologic evaluation of three metastatic melanoma patients treated with autologous melanoma-reactive TCR-transduced T cells.

Moore T, Wagner CR, Scurti GM, Hutchens KA, Godellas C, Clark AL, Kolawole EM, Hellman LM, Singh NK, Huyke FA, Wang SY, Calabrese KM, Embree HD, Orentas R, Shirai K, Dellacecca E, Garrett-Mayer E, Li M, Eby JM, Stiff PJ, Evavold BD, Baker BM, Le Poole IC, Dropulic B, Clark JI, Nishimura MI.

Cancer Immunol Immunother. 2017 Oct 20. doi: 10.1007/s00262-017-2073-0. [Epub ahead of print]

PMID:
29052782
2.

Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.

Singh NK, Riley TP, Baker SCB, Borrman T, Weng Z, Baker BM.

J Immunol. 2017 Oct 1;199(7):2203-2213. doi: 10.4049/jimmunol.1700744. Review.

PMID:
28923982
3.

Matrix degradability controls multicellularity of 3D cell migration.

Trappmann B, Baker BM, Polacheck WJ, Choi CK, Burdick JA, Chen CS.

Nat Commun. 2017 Aug 29;8(1):371. doi: 10.1038/s41467-017-00418-6.

4.

Peptide and Peptide-Dependent Motions in MHC Proteins: Immunological Implications and Biophysical Underpinnings.

Ayres CM, Corcelli SA, Baker BM.

Front Immunol. 2017 Aug 7;8:935. doi: 10.3389/fimmu.2017.00935. eCollection 2017. Review.

5.

Modeling Sequence-Dependent Peptide Fluctuations in Immunologic Recognition.

Ayres CM, Riley TP, Corcelli SA, Baker BM.

J Chem Inf Model. 2017 Aug 28;57(8):1990-1998. doi: 10.1021/acs.jcim.7b00118. Epub 2017 Jul 25.

PMID:
28696685
6.

Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.

Spear TT, Wang Y, Foley KC, Murray DC, Scurti GM, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI.

Cancer Immunol Immunother. 2017 Nov;66(11):1411-1424. doi: 10.1007/s00262-017-2032-9. Epub 2017 Jun 20.

PMID:
28634816
7.

How an alloreactive T-cell receptor achieves peptide and MHC specificity.

Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4792-E4801. doi: 10.1073/pnas.1700459114. Epub 2017 Jun 1.

PMID:
28572406
8.

Using Global Analysis to Extend the Accuracy and Precision of Binding Measurements with T cell Receptors and Their Peptide/MHC Ligands.

Blevins SJ, Baker BM.

Front Mol Biosci. 2017 Jan 31;4:2. doi: 10.3389/fmolb.2017.00002. eCollection 2017.

9.

ATLAS: A database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes.

Borrman T, Cimons J, Cosiano M, Purcaro M, Pierce BG, Baker BM, Weng Z.

Proteins. 2017 May;85(5):908-916. doi: 10.1002/prot.25260. Epub 2017 Feb 16.

PMID:
28160322
10.

MHC Bias by T Cell Receptors: Genetic Evidence for MHC and TCR Coevolution.

Baker BM, Evavold BD.

Trends Immunol. 2017 Jan;38(1):2-4. doi: 10.1016/j.it.2016.11.003. Epub 2016 Dec 9.

PMID:
27939452
11.

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.

Heo SJ, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA, Mauck RL.

Elife. 2016 Nov 30;5. pii: e18207. doi: 10.7554/eLife.18207.

12.

Ligand-Driven T Cell Receptor Selection in Celiac Disease.

Singh NK, Baker BM.

Structure. 2016 Oct 4;24(10):1623-1624. doi: 10.1016/j.str.2016.09.004.

13.

Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.

Harris DT, Wang N, Riley TP, Anderson SD, Singh NK, Procko E, Baker BM, Kranz DM.

J Biol Chem. 2016 Nov 18;291(47):24566-24578. Epub 2016 Sep 28.

14.

A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.

Riley TP, Ayres CM, Hellman LM, Singh NK, Cosiano M, Cimons JM, Anderson MJ, Piepenbrink KH, Pierce BG, Weng Z, Baker BM.

Protein Eng Des Sel. 2016 Dec;29(12):595-606. Epub 2016 Sep 13.

PMID:
27624308
15.

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.

Harris DT, Singh NK, Cai Q, Smith SN, Vander Kooi C, Procko E, Kranz DM, Baker BM.

Structure. 2016 Jul 6;24(7):1142-1154. doi: 10.1016/j.str.2016.04.011. Epub 2016 May 26.

16.

Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity.

Ayres CM, Scott DR, Corcelli SA, Baker BM.

Sci Rep. 2016 Apr 27;6:25070. doi: 10.1038/srep25070.

17.

Computational Modeling of T Cell Receptor Complexes.

Riley TP, Singh NK, Pierce BG, Weng Z, Baker BM.

Methods Mol Biol. 2016;1414:319-40. doi: 10.1007/978-1-4939-3569-7_19.

PMID:
27094300
18.

Computational Reprogramming of T Cell Antigen Receptor Binding Properties.

Riley TP, Singh NK, Pierce BG, Baker BM, Weng Z.

Methods Mol Biol. 2016;1414:305-18. doi: 10.1007/978-1-4939-3569-7_18.

PMID:
27094299
19.

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.

Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI.

J Leukoc Biol. 2016 Sep;100(3):545-57. doi: 10.1189/jlb.2A1215-561R. Epub 2016 Feb 26.

20.

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.

Hellman LM, Yin L, Wang Y, Blevins SJ, Riley TP, Belden OS, Spear TT, Nishimura MI, Stern LJ, Baker BM.

J Immunol Methods. 2016 May;432:95-101. doi: 10.1016/j.jim.2016.02.016. Epub 2016 Feb 18.

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