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Items: 1 to 20 of 75

1.

Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.

Spear TT, Wang Y, Foley KC, Murray DC, Scurti GM, Simms PE, Garrett-Mayer E, Hellman LM, Baker BM, Nishimura MI.

Cancer Immunol Immunother. 2017 Jun 20. doi: 10.1007/s00262-017-2032-9. [Epub ahead of print]

PMID:
28634816
2.

How an alloreactive T-cell receptor achieves peptide and MHC specificity.

Wang Y, Singh NK, Spear TT, Hellman LM, Piepenbrink KH, McMahan RH, Rosen HR, Vander Kooi CW, Nishimura MI, Baker BM.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4792-E4801. doi: 10.1073/pnas.1700459114. Epub 2017 Jun 1.

PMID:
28572406
3.

Using Global Analysis to Extend the Accuracy and Precision of Binding Measurements with T cell Receptors and Their Peptide/MHC Ligands.

Blevins SJ, Baker BM.

Front Mol Biosci. 2017 Jan 31;4:2. doi: 10.3389/fmolb.2017.00002. eCollection 2017.

4.

ATLAS: A database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes.

Borrman T, Cimons J, Cosiano M, Purcaro M, Pierce BG, Baker BM, Weng Z.

Proteins. 2017 May;85(5):908-916. doi: 10.1002/prot.25260. Epub 2017 Feb 16.

PMID:
28160322
5.

MHC Bias by T Cell Receptors: Genetic Evidence for MHC and TCR Coevolution.

Baker BM, Evavold BD.

Trends Immunol. 2017 Jan;38(1):2-4. doi: 10.1016/j.it.2016.11.003. Epub 2016 Dec 9.

PMID:
27939452
6.

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.

Heo SJ, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA, Mauck RL.

Elife. 2016 Nov 30;5. pii: e18207. doi: 10.7554/eLife.18207.

7.

Ligand-Driven T Cell Receptor Selection in Celiac Disease.

Singh NK, Baker BM.

Structure. 2016 Oct 4;24(10):1623-1624. doi: 10.1016/j.str.2016.09.004.

PMID:
27705812
8.

Deep Mutational Scans as a Guide to Engineering High Affinity T Cell Receptor Interactions with Peptide-bound Major Histocompatibility Complex.

Harris DT, Wang N, Riley TP, Anderson SD, Singh NK, Procko E, Baker BM, Kranz DM.

J Biol Chem. 2016 Nov 18;291(47):24566-24578. Epub 2016 Sep 28.

PMID:
27681597
9.

A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.

Riley TP, Ayres CM, Hellman LM, Singh NK, Cosiano M, Cimons JM, Anderson MJ, Piepenbrink KH, Pierce BG, Weng Z, Baker BM.

Protein Eng Des Sel. 2016 Dec;29(12):595-606. Epub 2016 Sep 13.

PMID:
27624308
10.

An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.

Harris DT, Singh NK, Cai Q, Smith SN, Vander Kooi CW, Procko E, Kranz DM, Baker BM.

Structure. 2016 Jul 6;24(7):1142-54. doi: 10.1016/j.str.2016.04.011. Epub 2016 May 26.

PMID:
27238970
11.

Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity.

Ayres CM, Scott DR, Corcelli SA, Baker BM.

Sci Rep. 2016 Apr 27;6:25070. doi: 10.1038/srep25070.

12.

Computational Modeling of T Cell Receptor Complexes.

Riley TP, Singh NK, Pierce BG, Weng Z, Baker BM.

Methods Mol Biol. 2016;1414:319-40. doi: 10.1007/978-1-4939-3569-7_19.

PMID:
27094300
13.

Computational Reprogramming of T Cell Antigen Receptor Binding Properties.

Riley TP, Singh NK, Pierce BG, Baker BM, Weng Z.

Methods Mol Biol. 2016;1414:305-18. doi: 10.1007/978-1-4939-3569-7_18.

PMID:
27094299
14.

Hepatitis C virus-cross-reactive TCR gene-modified T cells: a model for immunotherapy against diseases with genomic instability.

Spear TT, Riley TP, Lyons GE, Callender GG, Roszkowski JJ, Wang Y, Simms PE, Scurti GM, Foley KC, Murray DC, Hellman LM, McMahan RH, Iwashima M, Garrett-Mayer E, Rosen HR, Baker BM, Nishimura MI.

J Leukoc Biol. 2016 Sep;100(3):545-57. doi: 10.1189/jlb.2A1215-561R. Epub 2016 Feb 26.

PMID:
26921345
15.

Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide-MHC complexes.

Hellman LM, Yin L, Wang Y, Blevins SJ, Riley TP, Belden OS, Spear TT, Nishimura MI, Stern LJ, Baker BM.

J Immunol Methods. 2016 May;432:95-101. doi: 10.1016/j.jim.2016.02.016. Epub 2016 Feb 18.

16.

How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire.

Blevins SJ, Pierce BG, Singh NK, Riley TP, Wang Y, Spear TT, Nishimura MI, Weng Z, Baker BM.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1276-85. doi: 10.1073/pnas.1522069113. Epub 2016 Feb 16.

17.

FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function.

Thompson MG, Larson M, Vidrine A, Barrios K, Navarro F, Meyers K, Simms P, Prajapati K, Chitsike L, Hellman LM, Baker BM, Watkins SK.

J Immunol. 2015 Dec 15;195(12):5637-47. doi: 10.4049/jimmunol.1501758. Epub 2015 Nov 11.

18.

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity.

Adams JJ, Narayanan S, Birnbaum ME, Sidhu SS, Blevins SJ, Gee MH, Sibener LV, Baker BM, Kranz DM, Garcia KC.

Nat Immunol. 2016 Jan;17(1):87-94. doi: 10.1038/ni.3310. Epub 2015 Nov 2.

19.

Citizens unite for computational immunology!

Belden OS, Baker SC, Baker BM.

Trends Immunol. 2015 Jul;36(7):385-7. doi: 10.1016/j.it.2015.05.004.

20.

Changing the peptide specificity of a human T-cell receptor by directed evolution.

Smith SN, Wang Y, Baylon JL, Singh NK, Baker BM, Tajkhorshid E, Kranz DM.

Nat Commun. 2014 Nov 7;5:5223. doi: 10.1038/ncomms6223.

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