Effect of canola oil consumption on memory, synapse and neuropathology in the triple transgenic mouse model of Alzheimer's disease

Sci Rep. 2017 Dec 7;7(1):17134. doi: 10.1038/s41598-017-17373-3.

Abstract

In recent years consumption of canola oil has increased due to lower cost compared with olive oil and the perception that it shares its health benefits. However, no data are available on the effect of canola oil intake on Alzheimer's disease (AD) pathogenesis. Herein, we investigated the effect of chronic daily consumption of canola oil on the phenotype of a mouse model of AD that develops both plaques and tangles (3xTg). To this end mice received either regular chow or a chow diet supplemented with canola oil for 6 months. At this time point we found that chronic exposure to the canola-rich diet resulted in a significant increase in body weight and impairments in their working memory together with decrease levels of post-synaptic density protein-95, a marker of synaptic integrity, and an increase in the ratio of insoluble Aβ 42/40. No significant changes were observed in tau phosphorylation and neuroinflammation. Taken together, our findings do not support a beneficial effect of chronic canola oil consumption on two important aspects of AD pathophysiology which includes memory impairments as well as synaptic integrity. While more studies are needed, our data do not justify the current trend aimed at replacing olive oil with canola oil.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / genetics
  • Animals
  • Brain / drug effects*
  • Brain / pathology
  • Disease Models, Animal*
  • Disks Large Homolog 4 Protein / metabolism
  • Female
  • Male
  • Memory / drug effects*
  • Mice
  • Mice, Transgenic
  • Neuropathology*
  • Peptide Fragments / metabolism
  • Presenilin-1 / genetics
  • Rapeseed Oil / administration & dosage*
  • Synapses / drug effects*
  • Synapses / pathology
  • tau Proteins / genetics

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Disks Large Homolog 4 Protein
  • Dlg4 protein, mouse
  • Peptide Fragments
  • Presenilin-1
  • Rapeseed Oil
  • amyloid beta-protein (40-42)
  • presenilin 1, mouse
  • tau Proteins