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Neuromyelitis optica, aquaporin-4 antibodies, and neuroendocrine disorders.
Iorio R, Papi C. Iorio R, et al. Handb Clin Neurol. 2021;181:173-186. doi: 10.1016/B978-0-12-820683-6.00013-0. Handb Clin Neurol. 2021. PMID: 34238456 Review.
The distinctive immunopathological characteristics of NMOSD lesions, occurring in regions where AQP4 is highly expressed, supports a central role for AQP4-IgG in disease pathogenesis. ...Focus of this chapter is the involvement of hypothalamus and CVOs in AQP4 …
The distinctive immunopathological characteristics of NMOSD lesions, occurring in regions where AQP4 is highly expressed, supports a …
Sleep Disturbances Associated with Neurological Autoimmunity.
Devine MF, St Louis EK. Devine MF, et al. Neurotherapeutics. 2021 Jan;18(1):181-201. doi: 10.1007/s13311-021-01020-x. Epub 2021 Mar 30. Neurotherapeutics. 2021. PMID: 33786802 Free PMC article. Review.
Potential immune-mediated etiopathogenesis has been proposed for various sleep disorders including narcolepsy, Kleine-Levin syndrome, and Morvan syndrome. Sleep manifestations are also common in various autoimmune neurological syndromes, but may be underestimated as overri …
Potential immune-mediated etiopathogenesis has been proposed for various sleep disorders including narcolepsy, Kleine-Levin syndrome, …
Atypical presentations of neuromyelitis optica.
Sato D, Fujihara K. Sato D, et al. Arq Neuropsiquiatr. 2011 Oct;69(5):824-8. doi: 10.1590/s0004-282x2011000600019. Arq Neuropsiquiatr. 2011. PMID: 22042189 Free article. Review.
Examples are not limited to, but may include patients only with brain and/or brainstem lesions, narcolepsy with hypothalamic lesions or patients with intractable hiccups, nausea and vomiting. ...
Examples are not limited to, but may include patients only with brain and/or brainstem lesions, narcolepsy with hypothalamic lesions …
The pathophysiologic basis of secondary narcolepsy and hypersomnia.
Kanbayashi T, Sagawa Y, Takemura F, Ito SU, Tsutsui K, Hishikawa Y, Nishino S. Kanbayashi T, et al. Curr Neurol Neurosci Rep. 2011 Apr;11(2):235-41. doi: 10.1007/s11910-011-0178-y. Curr Neurol Neurosci Rep. 2011. PMID: 21298561
The symptoms of narcolepsy can occur during the course of other neurologic conditions (ie, symptomatic narcolepsy). ...In addition, these patients often share the clinical characteristics of neuromyelitis optica (NMO) and the detection of NMO-IgG (or anti-aquaporin- …
The symptoms of narcolepsy can occur during the course of other neurologic conditions (ie, symptomatic narcolepsy). ...In addi …
Symptomatic narcolepsy in patients with neuromyelitis optica and multiple sclerosis: new neurochemical and immunological implications.
Kanbayashi T, Shimohata T, Nakashima I, Yaguchi H, Yabe I, Nishizawa M, Shimizu T, Nishino S. Kanbayashi T, et al. Arch Neurol. 2009 Dec;66(12):1563-6. doi: 10.1001/archneurol.2009.264. Arch Neurol. 2009. PMID: 20008665
Four of these patients met the International Classification of Sleep Disorders 2 narcolepsy criteria. Three patients, including 2 patients with narcolepsy, were seropositive for anti-AQP4 antibody and diagnosed as having neuromyelitis optica-related disorder. …
Four of these patients met the International Classification of Sleep Disorders 2 narcolepsy criteria. Three patients, including 2 pat …
A patient with both narcolepsy and multiple sclerosis in association with Pandemrix vaccination.
Vrethem M, Malmgren K, Lindh J. Vrethem M, et al. J Neurol Sci. 2012 Oct 15;321(1-2):89-91. doi: 10.1016/j.jns.2012.07.025. Epub 2012 Jul 28. J Neurol Sci. 2012. PMID: 22841884
Narcolepsy with cataplexy is caused by a selective loss of hypocretin-producing neurons, but symptomatic narcolepsy can also result from hypothalamic and brainstem lesions caused by multiple sclerosis (MS). We report a previously healthy man who developed clinical a …
Narcolepsy with cataplexy is caused by a selective loss of hypocretin-producing neurons, but symptomatic narcolepsy can also r …
Hypothalamic immunopathology in anti-Ma-associated diencephalitis with narcolepsy-cataplexy.
Dauvilliers Y, Bauer J, Rigau V, Lalloyer N, Labauge P, Carlander B, Liblau R, Peyron C, Lassmann H. Dauvilliers Y, et al. JAMA Neurol. 2013 Oct;70(10):1305-10. doi: 10.1001/jamaneurol.2013.2831. JAMA Neurol. 2013. PMID: 23939463
IMPORTANCE: Idiopathic narcolepsy with cataplexy is thought to be an autoimmune disorder targeting hypothalamic hypocretin neurons. Symptomatic narcolepsy with low hypocretin level has been described in Ma antibody-associated encephalitis; however, the mechanisms un …
IMPORTANCE: Idiopathic narcolepsy with cataplexy is thought to be an autoimmune disorder targeting hypothalamic hypocretin neurons. S …
[Clinical features of NMO according to brain MRI findings].
Shimizu Y. Shimizu Y. Brain Nerve. 2010 Sep;62(9):933-43. Brain Nerve. 2010. PMID: 20844304 Review. Japanese.
The NMO-immunoglobulin (Ig) G auto-antibody (Ab), which binds to the aquaporin-4 (AQP4) water channel protein, is a marker for NMO. These clinical and immunological features have been used to distinguish NMO from multiple sclerosis (MS). In 1999, Wingerchuk et al. broadene …
The NMO-immunoglobulin (Ig) G auto-antibody (Ab), which binds to the aquaporin-4 (AQP4) water channel protein, is a marker for NMO. T …
Discovery of peptoid ligands for anti-aquaporin 4 antibodies.
Raveendra BL, Wu H, Baccala R, Reddy MM, Schilke J, Bennett JL, Theofilopoulos AN, Kodadek T. Raveendra BL, et al. Chem Biol. 2013 Mar 21;20(3):351-9. doi: 10.1016/j.chembiol.2012.12.009. Chem Biol. 2013. PMID: 23521793 Free PMC article.
In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to drive pathology by mediating complement-dependent destruction of astrocytes. Here, we apply recently developed chemical library screening tech …
In most NMO patients, autoantibodies to the water channel protein Aquaporin 4 (AQP4) are present at high levels and are thought to dr …
12 results