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Cleve Clin J Med. 2009 Dec;76(12):724-30. doi: 10.3949/ccjm.76a.09062.

An algorithm for managing warfarin resistance.

Author information

1
Department of Cardiovascular Medicine, Section of Vascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Abstract

Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.

PMID:
19952297
DOI:
10.3949/ccjm.76a.09062
[Indexed for MEDLINE]

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