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Synthesis and biological application of glyco- and peptide derivatives of fullerene C(60).
Tanzi L, Terreni M, Zhang Y. Tanzi L, et al. Eur J Med Chem. 2022 Feb 15;230:114104. doi: 10.1016/j.ejmech.2022.114104. Epub 2022 Jan 10. Eur J Med Chem. 2022. PMID: 35051749 Free article. Review.
Fullerenes have attracted considerable attention for their possible use in human therapy. Pure C(60) is soluble only in some organic solvents, but this could be overcome by chemical modifications. ...Also, amino acids-derivatives of fullerenes have been studied as anti-inf …
Fullerenes have attracted considerable attention for their possible use in human therapy. Pure C(60) is soluble only in some organic …
Distinct Binding Dynamics, Sites and Interactions of Fullerene and Fullerenols with Amyloid-β Peptides Revealed by Molecular Dynamics Simulations.
Liu Z, Zou Y, Zhang Q, Chen P, Liu Y, Qian Z. Liu Z, et al. Int J Mol Sci. 2019 Apr 25;20(8):2048. doi: 10.3390/ijms20082048. Int J Mol Sci. 2019. PMID: 31027286 Free PMC article.
The pathology Alzheimer's disease (AD) is associated with the self-assembly of amyloid-beta (Abeta) peptides into beta-sheet enriched fibrillar aggregates. ...The binding behaviors of C(60)/C(60)(OH)(6)/C(60)(OH)(12) to the Abeta(40) prot …
The pathology Alzheimer's disease (AD) is associated with the self-assembly of amyloid-beta (Abeta) peptides into beta- …
Effect of carbonaceous ultrafine particles on the structure and oligomerization of Aβ42 peptide.
Kaumbekova S, Amouei Torkmahalleh M, Umezawa M, Wang Y, Shah D. Kaumbekova S, et al. Environ Pollut. 2023 Apr 15;323:121273. doi: 10.1016/j.envpol.2023.121273. Epub 2023 Feb 11. Environ Pollut. 2023. PMID: 36780974
Among different air pollutants, ultrafine particles (UFPs; with aerodynamic diameter <100 nm) might pass through biological barriers and have a severe impact on human health, including early progression of neurodegenerative diseases such as Alzheimer's disease
Among different air pollutants, ultrafine particles (UFPs; with aerodynamic diameter <100 nm) might pass through biological barriers and …
Impact of ultrafine particles and secondary inorganic ions on early onset and progression of amyloid aggregation: Insights from molecular simulations.
Kaumbekova S, Torkmahalleh MA, Shah D. Kaumbekova S, et al. Environ Pollut. 2021 Sep 1;284:117147. doi: 10.1016/j.envpol.2021.117147. Epub 2021 Apr 14. Environ Pollut. 2021. PMID: 33894535
Alzheimer's disease (AD) is a neurodegenerative disorder, associated with the aggregation of amyloid beta (Abeta) peptides and formation of plaques. The impact of airborne particulate matter (PM) and ultrafine particles (UFPs), on early onset and progression
Alzheimer's disease (AD) is a neurodegenerative disorder, associated with the aggregation of amyloid beta (Abeta) pepti
Fullerenolates: metallated polyhydroxylated fullerenes with potent anti-amyloid activity.
Bobylev AG, Kornev AB, Bobyleva LG, Shpagina MD, Fadeeva IS, Fadeev RS, Deryabin DG, Balzarini J, Troshin PA, Podlubnaya ZA. Bobylev AG, et al. Org Biomol Chem. 2011 Aug 21;9(16):5714-9. doi: 10.1039/c1ob05067b. Epub 2011 Jun 28. Org Biomol Chem. 2011. PMID: 21713297 Free article.
It has been revealed for the first time that sodium fullerenolate Na(4)[C(60)(OH)(30)] (NaFL), a water soluble polyhydroxylated [60]fullerene derivative, destroys amyloid fibrils of the Abeta(1-42) peptide in the brain and prevents their formation in in vitro experi …
It has been revealed for the first time that sodium fullerenolate Na(4)[C(60)(OH)(30)] (NaFL), a water soluble polyhydroxylated [6
Dimensionality of carbon nanomaterials determines the binding and dynamics of amyloidogenic peptides: multiscale theoretical simulations.
Todorova N, Makarucha AJ, Hine ND, Mostofi AA, Yarovsky I. Todorova N, et al. PLoS Comput Biol. 2013;9(12):e1003360. doi: 10.1371/journal.pcbi.1003360. Epub 2013 Dec 5. PLoS Comput Biol. 2013. PMID: 24339760 Free PMC article.
Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the development of protein misfolding diseases such as Alzheimer's, Parkinson's and prion disease caused by aggregation and fibri …
Experimental studies have demonstrated that nanoparticles can affect the rate of protein self-assembly, possibly interfering with the develo …