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Best matches for alpha adrenergic AND ("QT" OR Torsad*):

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Items: 1 to 20 of 162

1.

Design, synthesis and cardiovascular evaluation of some aminoisopropanoloxy derivatives of xanthone.

Kubacka M, Szkaradek N, Mogilski S, Pańczyk K, Siwek A, Gryboś A, Filipek B, Żmudzki P, Marona H, Waszkielewicz AM.

Bioorg Med Chem. 2018 Jul 30;26(13):3773-3784. doi: 10.1016/j.bmc.2018.04.038. Epub 2018 Apr 18.

PMID:
29706529
3.

Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs.

Chiba K, Wada T, Nakamura Y, Cao X, Hagiwara-Nagasawa M, Izumi-Nakaseko H, Ando K, Tanaka K, Naito AT, Sugiyama A.

J Pharmacol Sci. 2017 Aug;134(4):239-246. doi: 10.1016/j.jphs.2017.08.002. Epub 2017 Aug 12.

4.

Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic.

Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu Z, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S, Soong TW.

Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295. doi: 10.1073/pnas.1617205114. Epub 2017 May 10.

5.

Hyperventilation assists proarrhythmia development during delayed repolarization in clofilium-treated, anaesthetized, mechanically ventilated rabbits.

Papp H, Sarusi A, Farkas AS, Takacs H, Kui P, Vincze D, Ivany E, Varro A, Papp JG, Forster T, Farkas A.

J Physiol Pharmacol. 2016 Oct;67(5):731-737.

6.

Mechanisms of IhERG/IKr Modulation by α1-Adrenoceptors in HEK293 Cells and Cardiac Myocytes.

Urrutia J, Alday A, Gallego M, Malagueta-Vieira LL, Aréchiga-Figueroa IA, Casis O, Sánchez-Chapula JA.

Cell Physiol Biochem. 2016;40(6):1261-1273. doi: 10.1159/000453180. Epub 2016 Dec 19.

7.

Molecular pathogenesis of long QT syndrome type 1.

Wu J, Ding WG, Horie M.

J Arrhythm. 2016 Oct;32(5):381-388. Epub 2016 Jan 27. Review.

8.

The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes.

Kuusela J, Kim J, Räsänen E, Aalto-Setälä K.

Stem Cell Rev. 2016 Dec;12(6):698-707.

9.

Acute and Long-Term Cardiovascular Effects of Stimulant, Guanfacine, and Combination Therapy for Attention-Deficit/Hyperactivity Disorder.

Sayer GR, McGough JJ, Levitt J, Cowen J, Sturm A, Castelo E, McCracken JT.

J Child Adolesc Psychopharmacol. 2016 Dec;26(10):882-888. Epub 2016 Aug 2.

10.

Shortening of the electromechanical window in the ketamine/xylazine-anesthetized guinea pig model to assess pro-arrhythmic risk in early drug development.

Morissette P, Regan C, Fitzgerald K, Gerenser P, Travis J, Wang S, Fanelli P, Sannajust F.

J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:171-82. doi: 10.1016/j.vascn.2016.06.003. Epub 2016 Jul 1.

PMID:
27377419
11.

AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders.

Ivachtchenko AV, Lavrovsky Y, Okun I.

J Alzheimers Dis. 2016 May 25;53(2):583-620. doi: 10.3233/JAD-151146. Review.

12.

A randomized, comparative, open-label study of efficacy and tolerability of alfuzosin, tamsulosin and silodosin in benign prostatic hyperplasia.

Manjunatha R, Pundarikaksha HP, Madhusudhana HR, Amarkumar J, Hanumantharaju BK.

Indian J Pharmacol. 2016 Mar-Apr;48(2):134-40. doi: 10.4103/0253-7613.178825.

13.

Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.

Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X.

Basic Res Cardiol. 2016 Jan;111(1):4. doi: 10.1007/s00395-015-0523-4. Epub 2015 Nov 26.

14.

The effects of cocaine on heart rate and electrocardiogram in zebrafish (Danio rerio).

Mersereau EJ, Poitra SL, Espinoza A, Crossley DA 2nd, Darland T.

Comp Biochem Physiol C Toxicol Pharmacol. 2015 Jun-Jul;172-173:1-6. doi: 10.1016/j.cbpc.2015.03.007. Epub 2015 Apr 3.

15.

β2 adrenergic receptor activation governs cardiac repolarization and arrhythmogenesis in a guinea pig model of heart failure.

Wang Y, Yuan J, Qian Z, Zhang X, Chen Y, Hou X, Zou J.

Sci Rep. 2015 Jan 8;5:7681. doi: 10.1038/srep07681.

16.

Assessment of anti-arrhythmic activity of antipsychotic drugs in an animal model: influence of non-cardiac α₁-adrenergic receptors.

Mow T, Frederiksen K, Thomsen MB.

Eur J Pharmacol. 2015 Feb 5;748:10-7. doi: 10.1016/j.ejphar.2014.12.012. Epub 2014 Dec 18.

PMID:
25530269
17.

Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1.

O-Uchi J, Rice JJ, Ruwald MH, Parks XX, Ronzier E, Moss AJ, Zareba W, Lopes CM.

J Mol Cell Cardiol. 2015 Feb;79:203-11. doi: 10.1016/j.yjmcc.2014.11.020. Epub 2014 Dec 2.

18.

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5383-92. doi: 10.1073/pnas.1419553111. Epub 2014 Dec 1.

19.

Use of ECG restitution (beat-to-beat QT-TQ interval analysis) to assess arrhythmogenic risk of QTc prolongation with guanfacine.

Fossa AA, Zhou M, Robinson A, Purkayastha J, Martin P.

Ann Noninvasive Electrocardiol. 2014 Nov;19(6):582-94. doi: 10.1111/anec.12202. Epub 2014 Sep 9.

PMID:
25200912
20.

Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of IKs, but preserved cAMP-dependent up-regulation.

Spätjens RL, Bébarová M, Seyen SR, Lentink V, Jongbloed RJ, Arens YH, Heijman J, Volders PG.

Cardiovasc Res. 2014 Oct 1;104(1):216-25. doi: 10.1093/cvr/cvu191. Epub 2014 Aug 18.

PMID:
25139741

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