Stabilizing effect of beta-cyclodextrin on Limaprost, a PGE1 derivative, in Limaprost alfadex tablets (Opalmon) in highly humid conditions.
Inoue Y, Sekiya N, Katayama K, Narutaki S, Yamamoto M, Iohara D, Hirayama F, Uekama K.
Inoue Y, et al.
Chem Pharm Bull (Tokyo). 2014;62(8):786-92. doi: 10.1248/cpb.c14-00150. Epub 2014 May 23.
Chem Pharm Bull (Tokyo). 2014.
PMID: 24859193
Free article.
Stabilization against humidity of Limaprost (a prostaglandin E1 derivative), which is currently marketed as Opalmon, was undertaken using beta-cyclodextrin (beta-CD). Aqueous solutions of Limaprost alfadex/dextran 40 were lyophilized with and without beta-CD. Limaprost …
Stabilization against humidity of Limaprost (a prostaglandin E1 derivative), which is currently marketed as Opalmon, was undertaken using be …