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Items: 17

1.

Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.

Ninou I, Kaffe E, Müller S, Budd DC, Stevenson CS, Ullmer C, Aidinis V.

Pulm Pharmacol Ther. 2018 Oct;52:32-40. doi: 10.1016/j.pupt.2018.08.003. Epub 2018 Sep 7.

PMID:
30201409
2.

Autotaxin-Lysophosphatidic Acid Signaling Contributes to Obesity-Induced Insulin Resistance in Muscle and Impairs Mitochondrial Metabolism.

D'Souza K, Nzirorera C, Cowie AM, Varghese GP, Trivedi P, Eichmann TO, Biswas D, Touaibia M, Morris AJ, Aidinis V, Kane DA, Pulinilkunnil T, Kienesberger PC.

J Lipid Res. 2018 Aug 2. pii: jlr.M082008. doi: 10.1194/jlr.M082008. [Epub ahead of print]

3.

Autotaxin in Pathophysiology and Pulmonary Fibrosis.

Ninou I, Magkrioti C, Aidinis V.

Front Med (Lausanne). 2018 Jun 13;5:180. doi: 10.3389/fmed.2018.00180. eCollection 2018. Review.

4.

The Autotaxin-Lysophosphatidic Acid Axis Promotes Lung Carcinogenesis.

Magkrioti C, Oikonomou N, Kaffe E, Mouratis MA, Xylourgidis N, Barbayianni I, Megadoukas P, Harokopos V, Valavanis C, Chun J, Kosma A, Stathopoulos GT, Bouros E, Bouros D, Syrigos K, Aidinis V.

Cancer Res. 2018 Jul 1;78(13):3634-3644. doi: 10.1158/0008-5472.CAN-17-3797. Epub 2018 May 3.

PMID:
29724718
5.

Hydroxamic Acids Constitute a Novel Class of Autotaxin Inhibitors that Exhibit in Vivo Efficacy in a Pulmonary Fibrosis Model.

Nikolaou A, Ninou I, Kokotou MG, Kaffe E, Afantitis A, Aidinis V, Kokotos G.

J Med Chem. 2018 Apr 26;61(8):3697-3711. doi: 10.1021/acs.jmedchem.8b00232. Epub 2018 Apr 18.

PMID:
29620892
6.

Hepatocyte autotaxin expression promotes liver fibrosis and cancer.

Kaffe E, Katsifa A, Xylourgidis N, Ninou I, Zannikou M, Harokopos V, Foka P, Dimitriadis A, Evangelou K, Moulas AN, Georgopoulou U, Gorgoulis VG, Dalekos GN, Aidinis V.

Hepatology. 2017 Apr;65(4):1369-1383. doi: 10.1002/hep.28973. Epub 2017 Feb 7.

PMID:
27981605
7.

Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors.

Vrontaki E, Melagraki G, Kaffe E, Mavromoustakos T, Kokotos G, Aidinis V, Afantitis A.

Curr Med Chem. 2016;23(17):1708-24. Review.

PMID:
26997151
8.

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life.

Katsifa A, Kaffe E, Nikolaidou-Katsaridou N, Economides AN, Newbigging S, McKerlie C, Aidinis V.

PLoS One. 2015 Nov 16;10(11):e0143083. doi: 10.1371/journal.pone.0143083. eCollection 2015.

9.

Autotaxin and Endotoxin-Induced Acute Lung Injury.

Mouratis MA, Magkrioti C, Oikonomou N, Katsifa A, Prestwich GD, Kaffe E, Aidinis V.

PLoS One. 2015 Jul 21;10(7):e0133619. doi: 10.1371/journal.pone.0133619. eCollection 2015.

10.

Non-cell autonomous and non-catalytic activities of ATX in the developing brain.

Greenman R, Gorelik A, Sapir T, Baumgart J, Zamor V, Segal-Salto M, Levin-Zaidman S, Aidinis V, Aoki J, Nitsch R, Vogt J, Reiner O.

Front Neurosci. 2015 Mar 4;9:53. doi: 10.3389/fnins.2015.00053. eCollection 2015.

11.

Autotaxin, a secreted lysophospholipase D, as a promising therapeutic target in chronic inflammation and cancer.

Barbayianni E, Kaffe E, Aidinis V, Kokotos G.

Prog Lipid Res. 2015 Apr;58:76-96. doi: 10.1016/j.plipres.2015.02.001. Epub 2015 Feb 20. Review.

PMID:
25704398
12.

Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.

Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y, Chung S, Karpurapu M, Deng J, Ranjan R, Xiao L, Jaffe HA, Corbridge SJ, Kelly EA, Jarjour NN, Chun J, Prestwich GD, Kaffe E, Ninou I, Aidinis V, Morris AJ, Smyth SS, Ackerman SJ, Natarajan V, Christman JW.

Am J Respir Crit Care Med. 2013 Oct 15;188(8):928-40. doi: 10.1164/rccm.201306-1014OC.

13.

A metabolically-stabilized phosphonate analog of lysophosphatidic acid attenuates collagen-induced arthritis.

Nikitopoulou I, Kaffe E, Sevastou I, Sirioti I, Samiotaki M, Madan D, Prestwich GD, Aidinis V.

PLoS One. 2013 Jul 29;8(7):e70941. doi: 10.1371/journal.pone.0070941. Print 2013.

14.

Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.

Sevastou I, Kaffe E, Mouratis MA, Aidinis V.

Biochim Biophys Acta. 2013 Jan;1831(1):42-60. doi: 10.1016/j.bbalip.2012.07.019. Epub 2012 Jul 31. Review.

PMID:
22867755
15.

Pulmonary autotaxin expression contributes to the pathogenesis of pulmonary fibrosis.

Oikonomou N, Mouratis MA, Tzouvelekis A, Kaffe E, Valavanis C, Vilaras G, Karameris A, Prestwich GD, Bouros D, Aidinis V.

Am J Respir Cell Mol Biol. 2012 Nov;47(5):566-74. doi: 10.1165/rcmb.2012-0004OC. Epub 2012 Jun 28.

PMID:
22744859
16.

Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.

Nikitopoulou I, Oikonomou N, Karouzakis E, Sevastou I, Nikolaidou-Katsaridou N, Zhao Z, Mersinias V, Armaka M, Xu Y, Masu M, Mills GB, Gay S, Kollias G, Aidinis V.

J Exp Med. 2012 May 7;209(5):925-33. doi: 10.1084/jem.20112012. Epub 2012 Apr 9.

17.

ATX expression and LPA signalling are vital for the development of the nervous system.

Fotopoulou S, Oikonomou N, Grigorieva E, Nikitopoulou I, Paparountas T, Thanassopoulou A, Zhao Z, Xu Y, Kontoyiannis DL, Remboutsika E, Aidinis V.

Dev Biol. 2010 Mar 15;339(2):451-64. doi: 10.1016/j.ydbio.2010.01.007. Epub 2010 Jan 15.

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