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Page 1
BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells.
J Immunother Cancer. 2023 Apr;11(4):e006567. doi: 10.1136/jitc-2022-006567.
J Immunother Cancer. 2023.
PMID: 37068796
Free PMC article.
Novel Evasion Mechanisms of the Classical Complement Pathway.
Garcia BL, Zwarthoff SA, Rooijakkers SH, Geisbrecht BV.
Garcia BL, et al. Among authors: zwarthoff sa.
J Immunol. 2016 Sep 15;197(6):2051-60. doi: 10.4049/jimmunol.1600863.
J Immunol. 2016.
PMID: 27591336
Free PMC article.
Review.
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Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae.
Aguinagalde Salazar L, den Boer MA, Castenmiller SM, Zwarthoff SA, de Haas C, Aerts PC, Beurskens FJ, Schuurman J, Heck AJR, van Kessel K, Rooijakkers SHM.
Aguinagalde Salazar L, et al. Among authors: zwarthoff sa.
Elife. 2023 Mar 22;12:e80669. doi: 10.7554/eLife.80669.
Elife. 2023.
PMID: 36947116
Free PMC article.
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C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases.
Zwarthoff SA, Widmer K, Kuipers A, Strasser J, Ruyken M, Aerts PC, de Haas CJC, Ugurlar D, den Boer MA, Vidarsson G, van Strijp JAG, Gros P, Parren PWHI, van Kessel KPM, Preiner J, Beurskens FJ, Schuurman J, Ricklin D, Rooijakkers SHM.
Zwarthoff SA, et al.
Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2102787118. doi: 10.1073/pnas.2102787118.
Proc Natl Acad Sci U S A. 2021.
PMID: 34155115
Free PMC article.
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Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation.
Cruz AR, Boer MAD, Strasser J, Zwarthoff SA, Beurskens FJ, de Haas CJC, Aerts PC, Wang G, de Jong RN, Bagnoli F, van Strijp JAG, van Kessel KPM, Schuurman J, Preiner J, Heck AJR, Rooijakkers SHM.
Cruz AR, et al. Among authors: zwarthoff sa.
Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2016772118. doi: 10.1073/pnas.2016772118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33563762
Free PMC article.
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Method for Depletion of IgG and IgM from Human Serum as Naive Complement Source.
Zwarthoff SA, Magnoni S, Aerts PC, van Kessel KPM, Rooijakkers SHM.
Zwarthoff SA, et al.
Methods Mol Biol. 2021;2227:21-32. doi: 10.1007/978-1-0716-1016-9_2.
Methods Mol Biol. 2021.
PMID: 33847927
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Functional Characterization of Alternative and Classical Pathway C3/C5 Convertase Activity and Inhibition Using Purified Models.
Zwarthoff SA, Berends ETM, Mol S, Ruyken M, Aerts PC, Józsi M, de Haas CJC, Rooijakkers SHM, Gorham RD Jr.
Zwarthoff SA, et al.
Front Immunol. 2018 Jul 23;9:1691. doi: 10.3389/fimmu.2018.01691. eCollection 2018.
Front Immunol. 2018.
PMID: 30083158
Free PMC article.
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