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Items: 1 to 20 of 55


p63 exerts spatio-temporal control of palatal epithelial cell fate to prevent cleft palate.

Richardson R, Mitchell K, Hammond NL, Mollo MR, Kouwenhoven EN, Wyatt ND, Donaldson IJ, Zeef L, Burgis T, Blance R, van Heeringen SJ, Stunnenberg HG, Zhou H, Missero C, Romano RA, Sinha S, Dixon MJ, Dixon J.

PLoS Genet. 2017 Jun 12;13(6):e1006828. doi: 10.1371/journal.pgen.1006828. eCollection 2017 Jun.


Identification of a de novo variant in CHUK in a patient with an EEC/AEC syndrome-like phenotype and hypogammaglobulinemia.

Khandelwal KD, Ockeloen CW, Venselaar H, Boulanger C, Brichard B, Sokal E, Pfundt R, Rinne T, van Beusekom E, Bloemen M, Vriend G, Revencu N, Carels CEL, van Bokhoven H, Zhou H.

Am J Med Genet A. 2017 May 17. doi: 10.1002/ajmg.a.38274. [Epub ahead of print]


Evolutionary re-wiring of p63 and the epigenomic regulatory landscape in keratinocytes and its potential implications on species-specific gene expression and phenotypes.

Sethi I, Gluck C, Zhou H, Buck MJ, Sinha S.

Nucleic Acids Res. 2017 Aug 21;45(14):8208-8224. doi: 10.1093/nar/gkx416.


Duplicated Enhancer Region Increases Expression of CTSB and Segregates with Keratolytic Winter Erythema in South African and Norwegian Families.

Ngcungcu T, Oti M, Sitek JC, Haukanes BI, Linghu B, Bruccoleri R, Stokowy T, Oakeley EJ, Yang F, Zhu J, Sultan M, Schalkwijk J, van Vlijmen-Willems IMJJ, von der Lippe C, Brunner HG, Ersland KM, Grayson W, Buechmann-Moller S, Sundnes O, Nirmala N, Morgan TM, van Bokhoven H, Steen VM, Hull PR, Szustakowski J, Staedtler F, Zhou H, Fiskerstrand T, Ramsay M.

Am J Hum Genet. 2017 May 4;100(5):737-750. doi: 10.1016/j.ajhg.2017.03.012. Epub 2017 Apr 27.


Transcriptome Analysis Identifies Multifaceted Regulatory Mechanisms Dictating a Genetic Switch from Neuronal Network Establishment to Maintenance During Postnatal Prefrontal Cortex Development.

Kroeze Y, Oti M, van Beusekom E, Cooijmans RH, van Bokhoven H, Kolk SM, Homberg JR, Zhou H.

Cereb Cortex. 2017 Jan 19. doi: 10.1093/cercor/bhw407. [Epub ahead of print]


Novel IRF6 Mutations Detected in Orofacial Cleft Patients by Targeted Massively Parallel Sequencing.

Khandelwal KD, Ishorst N, Zhou H, Ludwig KU, Venselaar H, Gilissen C, Thonissen M, van Rooij IA, Dreesen K, Steehouwer M, van de Vorst M, Bloemen M, van Beusekom E, Roosenboom J, Borstlap W, Admiraal R, Dormaar T, Schoenaers J, Vander Poorten V, Hens G, Verdonck A, Bergé S, Roeleveldt N, Vriend G, Devriendt K, Brunner HG, Mangold E, Hoischen A, van Bokhoven H, Carels CE.

J Dent Res. 2017 Feb;96(2):179-185. doi: 10.1177/0022034516678829. Epub 2016 Nov 13.


Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis.

Ockeloen CW, Khandelwal KD, Dreesen K, Ludwig KU, Sullivan R, van Rooij IALM, Thonissen M, Swinnen S, Phan M, Conte F, Ishorst N, Gilissen C, RoaFuentes L, van de Vorst M, Henkes A, Steehouwer M, van Beusekom E, Bloemen M, Vankeirsbilck B, Bergé S, Hens G, Schoenaers J, Poorten VV, Roosenboom J, Verdonck A, Devriendt K, Roeleveldt N, Jhangiani SN, Vissers LELM, Lupski JR, de Ligt J, Von den Hoff JW, Pfundt R, Brunner HG, Zhou H, Dixon J, Mangold E, van Bokhoven H, Dixon MJ, Kleefstra T, Hoischen A, Carels CEL.

Genet Med. 2016 Nov;18(11):1158-1162. doi: 10.1038/gim.2016.10. Epub 2016 Mar 10.


Tooth agenesis and orofacial clefting: genetic brothers in arms?

Phan M, Conte F, Khandelwal KD, Ockeloen CW, Bartzela T, Kleefstra T, van Bokhoven H, Rubini M, Zhou H, Carels CE.

Hum Genet. 2016 Dec;135(12):1299-1327. Epub 2016 Oct 3. Review.


Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling.

Benevento M, Iacono G, Selten M, Ba W, Oudakker A, Frega M, Keller J, Mancini R, Lewerissa E, Kleefstra T, Stunnenberg HG, Zhou H, van Bokhoven H, Nadif Kasri N.

Neuron. 2016 Jul 20;91(2):341-55. doi: 10.1016/j.neuron.2016.06.003. Epub 2016 Jun 30.


Retinoic acid signalling in the development of the epidermis, the limbs and the secondary palate.

Mammadova A, Zhou H, Carels CE, Von den Hoff JW.

Differentiation. 2016 Dec;92(5):326-335. doi: 10.1016/j.diff.2016.05.001. Epub 2016 May 26. Review.


Perinatal reduction of functional serotonin transporters results in developmental delay.

Kroeze Y, Dirven B, Janssen S, Kröhnke M, Barte RM, Middelman A, van Bokhoven H, Zhou H, Homberg JR.

Neuropharmacology. 2016 Oct;109:96-111. doi: 10.1016/j.neuropharm.2016.05.012. Epub 2016 May 18.


Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus.

Kroeze Y, Peeters D, Boulle F, van den Hove DL, van Bokhoven H, Zhou H, Homberg JR.

Transl Psychiatry. 2016 Apr 12;6:e779. doi: 10.1038/tp.2016.60. No abstract available.


CTCF-mediated chromatin loops enclose inducible gene regulatory domains.

Oti M, Falck J, Huynen MA, Zhou H.

BMC Genomics. 2016 Mar 22;17:252. doi: 10.1186/s12864-016-2516-6.


Systematic analysis of copy number variants of a large cohort of orofacial cleft patients identifies candidate genes for orofacial clefts.

Conte F, Oti M, Dixon J, Carels CE, Rubini M, Zhou H.

Hum Genet. 2016 Jan;135(1):41-59. doi: 10.1007/s00439-015-1606-x. Epub 2015 Nov 11.


Genome-wide p63-regulated gene expression in differentiating epidermal keratinocytes.

Oti M, Kouwenhoven EN, Zhou H.

Genom Data. 2015 Jun 9;5:159-63. doi: 10.1016/j.gdata.2015.06.002. eCollection 2015 Sep.


Choices for Induction of Pluripotency: Recent Developments in Human Induced Pluripotent Stem Cell Reprogramming Strategies.

Brouwer M, Zhou H, Nadif Kasri N.

Stem Cell Rev. 2016 Feb;12(1):54-72. doi: 10.1007/s12015-015-9622-8. Review.


Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus.

Kroeze Y, Peeters D, Boulle F, Pawluski JL, van den Hove DL, van Bokhoven H, Zhou H, Homberg JR.

Transl Psychiatry. 2015 Sep 22;5:e642. doi: 10.1038/tp.2015.145. Erratum in: Transl Psychiatry. 2016;6:e779. Pawluski, JL [Added].


p63 supports aerobic respiration through hexokinase II.

Viticchiè G, Agostini M, Lena AM, Mancini M, Zhou H, Zolla L, Dinsdale D, Saintigny G, Melino G, Candi E.

Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11577-82. doi: 10.1073/pnas.1508871112. Epub 2015 Aug 31.


p63 controls cell migration and invasion by transcriptional regulation of MTSS1.

Giacobbe A, Compagnone M, Bongiorno-Borbone L, Antonov A, Markert EK, Zhou JH, Annicchiarico-Petruzzelli M, Melino G, Peschiaroli A.

Oncogene. 2016 Mar 24;35(12):1602-8. doi: 10.1038/onc.2015.230. Epub 2015 Jun 29.


Transcription factor p63 bookmarks and regulates dynamic enhancers during epidermal differentiation.

Kouwenhoven EN, Oti M, Niehues H, van Heeringen SJ, Schalkwijk J, Stunnenberg HG, van Bokhoven H, Zhou H.

EMBO Rep. 2015 Jul;16(7):863-78. doi: 10.15252/embr.201439941. Epub 2015 Jun 1.

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