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Items: 1 to 20 of 34

1.
2.

Nmnat mitigates sensory dysfunction in a Drosophila model of paclitaxel-induced peripheral neuropathy.

Brazill JM, Cruz B, Zhu Y, Zhai RG.

Dis Model Mech. 2018 Jun 12;11(6). pii: dmm032938. doi: 10.1242/dmm.032938.

3.

Publisher Correction: Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.

Li C, Brazill JM, Liu S, Bello C, Zhu Y, Morimoto M, Cascio L, Pauly R, Diaz-Perez Z, Malicdan MCV, Wang H, Boccuto L, Schwartz CE, Gahl WA, Boerkoel CF, Zhai RG.

Nat Commun. 2018 Jan 18;9(1):337. doi: 10.1038/s41467-017-02462-8.

4.

Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.

Li C, Brazill JM, Liu S, Bello C, Zhu Y, Morimoto M, Cascio L, Pauly R, Diaz-Perez Z, Malicdan MCV, Wang H, Boccuto L, Schwartz CE, Gahl WA, Boerkoel CF, Zhai RG.

Nat Commun. 2017 Nov 2;8(1):1257. doi: 10.1038/s41467-017-01289-7. Erratum in: Nat Commun. 2018 Jan 18;9(1):337.

5.

Defining Disease, Diagnosis, and Translational Medicine within a Homeostatic Perturbation Paradigm: The National Institutes of Health Undiagnosed Diseases Program Experience.

Gall T, Valkanas E, Bello C, Markello T, Adams C, Bone WP, Brandt AJ, Brazill JM, Carmichael L, Davids M, Davis J, Diaz-Perez Z, Draper D, Elson J, Flynn ED, Godfrey R, Groden C, Hsieh CK, Fischer R, Golas GA, Guzman J, Huang Y, Kane MS, Lee E, Li C, Links AE, Maduro V, Malicdan MCV, Malik FS, Nehrebecky M, Park J, Pemberton P, Schaffer K, Simeonov D, Sincan M, Smedley D, Valivullah Z, Wahl C, Washington N, Wolfe LA, Xu K, Zhu Y, Gahl WA, Tifft CJ, Toro C, Adams DR, He M, Robinson PN, Haendel MA, Zhai RG, Boerkoel CF.

Front Med (Lausanne). 2017 May 26;4:62. doi: 10.3389/fmed.2017.00062. eCollection 2017.

6.

NMNAT: It's an NAD+ synthase… It's a chaperone… It's a neuroprotector.

Brazill JM, Li C, Zhu Y, Zhai RG.

Curr Opin Genet Dev. 2017 Jun;44:156-162. doi: 10.1016/j.gde.2017.03.014. Epub 2017 Apr 23. Review.

7.

Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging.

Ruetenik AL, Ocampo A, Ruan K, Zhu Y, Li C, Zhai RG, Barrientos A.

Microb Cell. 2016 Jul 26;3(8):338-351. doi: 10.15698/mic2016.08.518.

8.

Alternative splicing of Drosophila Nmnat functions as a switch to enhance neuroprotection under stress.

Ruan K, Zhu Y, Li C, Brazill JM, Zhai RG.

Nat Commun. 2015 Nov 30;6:10057. doi: 10.1038/ncomms10057.

9.

NMNATs, evolutionarily conserved neuronal maintenance factors.

Ali YO, Li-Kroeger D, Bellen HJ, Zhai RG, Lu HC.

Trends Neurosci. 2013 Nov;36(11):632-40. doi: 10.1016/j.tins.2013.07.002. Epub 2013 Aug 20. Review.

10.

Mislocalization of neuronal mitochondria reveals regulation of Wallerian degeneration and NMNAT/WLD(S)-mediated axon protection independent of axonal mitochondria.

Kitay BM, McCormack R, Wang Y, Tsoulfas P, Zhai RG.

Hum Mol Genet. 2013 Apr 15;22(8):1601-14. doi: 10.1093/hmg/ddt009. Epub 2013 Jan 11.

11.

The role of autophagy in Nmnat-mediated protection against hypoxia-induced dendrite degeneration.

Wen Y, Zhai RG, Kim MD.

Mol Cell Neurosci. 2013 Jan;52:140-51. doi: 10.1016/j.mcn.2012.11.008. Epub 2012 Nov 15.

12.

Nicotinamide mononucleotide adenylyltransferase maintains active zone structure by stabilizing Bruchpilot.

Zang S, Ali YO, Ruan K, Zhai RG.

EMBO Rep. 2013 Jan;14(1):87-94. doi: 10.1038/embor.2012.181. Epub 2012 Nov 16.

13.

β-N-methylamino-L-alanine induces neurological deficits and shortened life span in Drosophila.

Zhou X, Escala W, Papapetropoulos S, Zhai RG.

Toxins (Basel). 2010 Nov;2(11):2663-79. doi: 10.3390/toxins2112663. Epub 2010 Nov 3.

14.

Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini.

Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG.

J Biol Chem. 2012 Jan 20;287(4):2317-27. doi: 10.1074/jbc.M111.273730. Epub 2011 Nov 8.

15.

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy.

Ljungberg MC, Ali YO, Zhu J, Wu CS, Oka K, Zhai RG, Lu HC.

Hum Mol Genet. 2012 Jan 15;21(2):251-67. doi: 10.1093/hmg/ddr492. Epub 2011 Oct 25.

16.

NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy.

Ali YO, Ruan K, Zhai RG.

Hum Mol Genet. 2012 Jan 15;21(2):237-50. doi: 10.1093/hmg/ddr449. Epub 2011 Sep 30.

17.

Nmnat exerts neuroprotective effects in dendrites and axons.

Wen Y, Parrish JZ, He R, Zhai RG, Kim MD.

Mol Cell Neurosci. 2011 Sep;48(1):1-8. doi: 10.1016/j.mcn.2011.05.002. Epub 2011 May 9.

18.

Nicotinamide mononucleotide adenylyltransferase is a stress response protein regulated by the heat shock factor/hypoxia-inducible factor 1alpha pathway.

Ali YO, McCormack R, Darr A, Zhai RG.

J Biol Chem. 2011 May 27;286(21):19089-99. doi: 10.1074/jbc.M111.219295. Epub 2011 Apr 8.

19.

Assaying locomotor, learning, and memory deficits in Drosophila models of neurodegeneration.

Ali YO, Escala W, Ruan K, Zhai RG.

J Vis Exp. 2011 Mar 11;(49). pii: 2504. doi: 10.3791/2504.

20.

Dealing with misfolded proteins: examining the neuroprotective role of molecular chaperones in neurodegeneration.

Ali YO, Kitay BM, Zhai RG.

Molecules. 2010 Oct 8;15(10):6859-87. doi: 10.3390/molecules15106859. Review.

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