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Cancer Biol Med. 2016 Dec;13(4):514-518. doi: 10.20892/j.issn.2095-3941.2016.0070.

Work-up and management of a high-risk patient with primary central nervous system lymphoma.

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Division of Hematology and Bone Marrow Transplantation.
Department of Nuclear Medicine and Molecular Imaging, N.N. Blokhin Russian Cancer Research Center, Moscow 115478, Russia.


Primary central nervous system lymphoma (PCNSL) is a rare disorder that, in 95% of cases, represents diffuse large B-cell lymphoma. As such, making an accurate diagnosis is important. At present, stereotactic-guided biopsy is a recognized method of choice for tissue analysis. However, the diagnostic work-up for high-risk patients is determined by their performance status. Here, we report a case of PCNSL in a high-risk patient, for whom diagnosis was established by cerebrospinal fluid cytology and flow cytometry, which significantly shortened a diagnostic work-up period and allowed for the immediate treatment of the patient.


Brain neoplasms; CNS; cerebrospinal fluid; flow cytometry; high risk; lymphoma

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