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ZCCHC13-mediated induction of human liver cancer is associated with the modulation of DNA methylation and the AKT/ERK signaling pathway.
Li Z, Li Z, Wang L, Long C, Zheng Z, Zhuang X. Li Z, et al. J Transl Med. 2019 Apr 2;17(1):108. doi: 10.1186/s12967-019-1852-0. J Transl Med. 2019. PMID: 30940166 Free PMC article.
The presence of anti-ZCCHC13 antibodies was determined by an ELISA. RESULTS: ZCCHC13 expression was frequently upregulated in human liver cancer cells and tissues. Compared with heathy individuals, sera from patients with HCC displayed a significant response to the …
The presence of anti-ZCCHC13 antibodies was determined by an ELISA. RESULTS: ZCCHC13 expression was frequently upregulated in …
Novel biomarker ZCCHC13 revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia.
Li Z, Chen S, Yang Y, Zhuang X, Tzeng CM. Li Z, et al. Cell Death Discov. 2018 Feb 26;4:36. doi: 10.1038/s41420-018-0033-x. eCollection 2018 Dec. Cell Death Discov. 2018. PMID: 29531833 Free PMC article.
Mechanistic analyses indicated that ZCCHC13 increased c-MYC expression through the p-AKT and p-ERK pathways. ...Our data, for the first time, demonstrate that ZCCHC13 is an important signaling molecule that positively regulates the AKT/MAPK/c-MYC pathway and that me …
Mechanistic analyses indicated that ZCCHC13 increased c-MYC expression through the p-AKT and p-ERK pathways. ...Our data, for the fir …
X chromosome-linked genes in the mature sperm influence semen quality and fertility of breeding bulls.
Swathi D, Ramya L, Archana SS, Lavanya M, Krishnappa B, Binsila BK, Selvaraju S. Swathi D, et al. Gene. 2022 Sep 25;839:146727. doi: 10.1016/j.gene.2022.146727. Epub 2022 Jul 11. Gene. 2022. PMID: 35835407
The transcript pool corresponding to the X-linked genes represents embryonic organ development (p = 0.03) and reproduction (p = 0.02) processes in cattle and buffalo sperm, respectively. The mRNA expression levels of X-linked genes, RPL10 and ZCCHC13 in cattle; AKAP4, TSPA …
The transcript pool corresponding to the X-linked genes represents embryonic organ development (p = 0.03) and reproduction (p = 0.02) proces …
Identification of an imprinted gene cluster in the X-inactivation center.
Kobayashi S, Totoki Y, Soma M, Matsumoto K, Fujihara Y, Toyoda A, Sakaki Y, Okabe M, Ishino F. Kobayashi S, et al. PLoS One. 2013 Aug 6;8(8):e71222. doi: 10.1371/journal.pone.0071222. Print 2013. PLoS One. 2013. PMID: 23940725 Free PMC article.
Further analysis of the imprinting status of adjacent locus led to the discovery of a large cluster of imprinted genes expressed from the Xp: Jpx, Ftx and Zcchc13. To our knowledge, this is the first identified cluster of imprinted genes in the cis-acting regulatory region …
Further analysis of the imprinting status of adjacent locus led to the discovery of a large cluster of imprinted genes expressed from the Xp …
Breast cancer prediction with transcriptome profiling using feature selection and machine learning methods.
Taghizadeh E, Heydarheydari S, Saberi A, JafarpoorNesheli S, Rezaeijo SM. Taghizadeh E, et al. BMC Bioinformatics. 2022 Oct 1;23(1):410. doi: 10.1186/s12859-022-04965-8. BMC Bioinformatics. 2022. PMID: 36183055 Free PMC article.
The results showed that achieved AUC for the LGR + LGR classifier belonged to the 20 biomarkers as follows: TMEM212, SNORD115-13, ATP1A4, FRG2, CFHR4, ZCCHC13, FLJ46361, LY6G6E, ZNF323, KRT28, KRT25, LPPR5, C10orf99, PRKACG, SULT2A1, GRIN2C, EN2, GBA2, CUX2, and SNORA66. . …
The results showed that achieved AUC for the LGR + LGR classifier belonged to the 20 biomarkers as follows: TMEM212, SNORD115-13, ATP1A4, FR …
Identification of nine human-specific frameshift mutations by comparative analysis of the human and the chimpanzee genome sequences.
Hahn Y, Lee B. Hahn Y, et al. Bioinformatics. 2005 Jun;21 Suppl 1:i186-94. doi: 10.1093/bioinformatics/bti1000. Bioinformatics. 2005. PMID: 15961456
Using this procedure, we identified nine genes, BASE, DNAJB3, FLJ33674, HEJ1, NTSR2, RPL13AP, SCGB1D4, WBSCR27 and ZCCHC13, that show human-specific alterations including truncations of the C-terminus. ...
Using this procedure, we identified nine genes, BASE, DNAJB3, FLJ33674, HEJ1, NTSR2, RPL13AP, SCGB1D4, WBSCR27 and ZCCHC13, that show …