Format

Send to

Choose Destination
Int J Neurosci. 2004 Oct;114(10):1365-88.

The herbal prescription youkongdan modulates rodent memory, ischemic damage and cortical mRNA gene expression.

Author information

1
Jaseng Research Institute of Biotechnology and Bioscience, Seoul, Korea.

Abstract

The effects of the herbal prescription youkongdan (YKD) on memory performance of rodents following cerebral ischemia/reperfusion and scopolamine administration were measured and compared to the age-related changes in mRNA expression induced by dietary supplementation of YKD. Following ischemia, YKD decreased neuronal cell loss in the CA1 region of rat hippocampus by 89% relative to controls. YKD improved the water maze performance of both ischemic and scopolamine-treated animals. Dietary administration of YKD resulted in significant modulation of Egr1, Grp78, Hsp86, SOD1, and alphaB crystallin mRNA expression and a trend toward increased exploratory behavior in older mice.

PMID:
15370193
DOI:
10.1080/00207450490489107
[Indexed for MEDLINE]

Publication types, MeSH terms, Substances

Publication types

MeSH terms

Substances

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center