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Sci Rep. 2015 Nov 27;5:17323. doi: 10.1038/srep17323.

In vitro follicle growth supports human oocyte meiotic maturation.

Author information

1
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
2
Center for Reproductive Science, Northwestern University, Evanston, IL 60208, USA.
3
Master of Biotechnology Program, Northwestern University, Evanston, IL 60208, USA.
4
Northwestern Medical Group, Northwestern University, Chicago, IL, 60611, USA.
5
Department of Biomedical Engineering, College of Engineering and Medical School, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

In vitro follicle growth is a potential approach to preserve fertility for young women who are facing a risk of premature ovarian failure (POF) caused by radiation or chemotherapy. Our two-step follicle culture strategy recapitulated the dynamic human follicle growth environment in vitro. Follicles developed from the preantral to antral stage, and, for the first time, produced meiotically competent metaphase II (MII) oocytes after in vitro maturation (IVM).

PMID:
26612176
PMCID:
PMC4661442
DOI:
10.1038/srep17323
[Indexed for MEDLINE]
Free PMC Article

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