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Items: 1 to 20 of 48

1.

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.

Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM.

ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5.

2.

Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK).

Shapiro JA, Varga JJ, Parsonage D, Walton W, Redinbo MR, Ross LJ, White EL, Bostwick R, Wuest WM, Claiborne A, Goldberg JB.

ChemMedChem. 2019 Jan 8;14(1):78-82. doi: 10.1002/cmdc.201800652. Epub 2018 Dec 3.

PMID:
30376607
3.

An Investigation into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics.

Kontos RC, Schallenhammer SA, Bentley BS, Morrison KR, Feliciano JA, Tasca JA, Kaplan AR, Bezpalko MW, Kassel WS, Wuest WM, Minbiole KPC.

ChemMedChem. 2019 Jan 8;14(1):83-87. doi: 10.1002/cmdc.201800622. Epub 2018 Dec 18.

PMID:
30358105
4.

Epoxy Isonitriles, A Unique Class of Antibiotics: Synthesis of Their Metabolites and Biological Investigations.

Ernouf G, Wilt IK, Zahim S, Wuest WM.

Chembiochem. 2018 Dec 4;19(23):2448-2452. doi: 10.1002/cbic.201800550. Epub 2018 Oct 31.

PMID:
30277650
5.

Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product.

Shapiro JA, Morrison KR, Chodisetty SS, Musaev DG, Wuest WM.

Org Lett. 2018 Sep 21;20(18):5922-5926. doi: 10.1021/acs.orglett.8b02599. Epub 2018 Sep 10.

PMID:
30199265
6.

Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters.

Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E.

ACS Infect Dis. 2018 Nov 9;4(11):1540-1545. doi: 10.1021/acsinfecdis.8b00161. Epub 2018 Aug 28.

PMID:
30132650
7.

From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow-Spectrum Antibiotics?

Shapiro JA, Kaplan AR, Wuest WM.

Chembiochem. 2019 Jan 2;20(1):34-39. doi: 10.1002/cbic.201800383. Epub 2018 Sep 21.

PMID:
30088315
8.

Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440.

Giglio KM, Keohane CE, Stodghill PV, Steele AD, Fetzer C, Sieber SA, Filiatrault MJ, Wuest WM.

ACS Infect Dis. 2018 Aug 10;4(8):1179-1187. doi: 10.1021/acsinfecdis.8b00041. Epub 2018 Jun 5.

PMID:
29801413
9.

A new class of synthetic retinoid antibiotics effective against bacterial persisters.

Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E.

Nature. 2018 Apr 5;556(7699):103-107. doi: 10.1038/nature26157. Epub 2018 Mar 28.

PMID:
29590091
10.

Claramines: A New Class Of Broad-Spectrum Antimicrobial Agents With Bimodal Activity.

Blanchet M, Borselli D, Rodallec A, Peiretti F, Vidal N, Bolla JM, Digiorgio C, Morrison KR, Wuest WM, Brunel JM.

ChemMedChem. 2018 May 23;13(10):1018-1027. doi: 10.1002/cmdc.201800073. Epub 2018 Apr 10.

PMID:
29465814
11.

Dual Inhibitor of Staphylococcus aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins.

Hofbauer B, Vomacka J, Stahl M, Korotkov VS, Jennings MC, Wuest WM, Sieber SA.

Biochemistry. 2018 Mar 20;57(11):1814-1820. doi: 10.1021/acs.biochem.7b01271. Epub 2018 Mar 1.

PMID:
29451388
12.

Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action.

Steele AD, Ernouf G, Lee YE, Wuest WM.

Org Lett. 2018 Feb 16;20(4):1126-1129. doi: 10.1021/acs.orglett.8b00054. Epub 2018 Feb 1.

PMID:
29388431
13.

Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase.

Keohane CE, Steele AD, Fetzer C, Khowsathit J, Van Tyne D, Moynié L, Gilmore MS, Karanicolas J, Sieber SA, Wuest WM.

J Am Chem Soc. 2018 Feb 7;140(5):1774-1782. doi: 10.1021/jacs.7b11212. Epub 2018 Jan 24.

PMID:
29300464
14.

Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria.

Solinski AE, Ochoa C, Lee YE, Paniak T, Kozlowski MC, Wuest WM.

ACS Infect Dis. 2018 Feb 9;4(2):118-122. doi: 10.1021/acsinfecdis.7b00178. Epub 2017 Dec 13.

PMID:
29236466
15.

Hybrid BisQACs: Potent Biscationic Quaternary Ammonium Compounds Merging the Structures of Two Commercial Antiseptics.

Schallenhammer SA, Duggan SM, Morrison KR, Bentley BS, Wuest WM, Minbiole KPC.

ChemMedChem. 2017 Dec 7;12(23):1931-1934. doi: 10.1002/cmdc.201700597. Epub 2017 Nov 14.

16.

EroS Enzyme from Aliivibrio fischeri Plays Cupid to Choanoflagellates.

Rossiter SE, Wuest WM.

Chembiochem. 2017 Dec 5;18(23):2298-2300. doi: 10.1002/cbic.201700552. Epub 2017 Oct 27.

17.

Natural Products as Platforms To Overcome Antibiotic Resistance.

Rossiter SE, Fletcher MH, Wuest WM.

Chem Rev. 2017 Oct 11;117(19):12415-12474. doi: 10.1021/acs.chemrev.7b00283. Epub 2017 Sep 27. Review.

18.

A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method.

Fletcher MH, Burns-Lynch CE, Knouse KW, Abraham LT, DeBrosse CW, Wuest WM.

RSC Adv. 2017 Jun 7;7(47):29835-29838. doi: 10.1039/c7ra06045a.

19.

Efflux Pumps Might Not Be the Major Drivers of QAC Resistance in Methicillin-Resistant Staphylococcus aureus.

Jennings MC, Forman ME, Duggan SM, Minbiole KPC, Wuest WM.

Chembiochem. 2017 Aug 17;18(16):1573-1577. doi: 10.1002/cbic.201700233. Epub 2017 Jun 27.

20.

Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms.

Solinski AE, Koval AB, Brzozowski RS, Morrison KR, Fraboni AJ, Carson CE, Eshraghi AR, Zhou G, Quivey RG Jr, Voelz VA, Buttaro BA, Wuest WM.

J Am Chem Soc. 2017 May 31;139(21):7188-7191. doi: 10.1021/jacs.7b03879. Epub 2017 May 17.

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