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Items: 1 to 20 of 146


CYP2D6 haplotypes with enhancer single-nucleotide polymorphism rs5758550 and rs16947 (*2 allele): implications for CYP2D6 genotyping panels.

Ray B, Ozcagli E, Sadee W, Wang D.

Pharmacogenet Genomics. 2018 Nov 28. doi: 10.1097/FPC.0000000000000363. [Epub ahead of print]


Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence.

Lee SH, Ahn WY, Seweryn M, Sadee W.

BMC Genomics. 2018 Nov 20;19(1):826. doi: 10.1186/s12864-018-5219-3.


Interactions Between Regulatory Variants in CYP7A1 (Cholesterol 7α-Hydroxylase) Promoter and Enhancer Regions Regulate CYP7A1 Expression.

Wang D, Hartmann K, Seweryn M, Sadee W.

Circ Genom Precis Med. 2018 Oct;11(10):e002082. doi: 10.1161/CIRCGEN.118.002082.


Testing genetic modifiers of behavior and response to atomoxetine in autism spectrum disorder with ADHD.

Barrie ES, Pinsonneault JK, Sadee W, Hollway JA, Handen BL, Smith T, Arnold LE, Butter E, Hansen-Kiss E, Herman GE, Aman MG.

J Dev Phys Disabil. 2018 Jun;30(3):355-371. doi: 10.1007/s10882-018-9590-4. Epub 2018 Mar 5.


IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.

Locke LW, Crouser ED, White P, Julian MW, Guirado Caceres E, Papp AC, Le VT, Sadee W, Schlesinger LS.

Am J Respir Cell Mol Biol. 2018 Aug 22. doi: 10.1165/rcmb.2018-0053OC. [Epub ahead of print]


Blood pressure signature genes and blood pressure response to thiazide diuretics: results from the PEAR and PEAR-2 studies.

Sá ACC, Webb A, Gong Y, McDonough CW, Shahin MH, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA.

BMC Med Genomics. 2018 Jun 20;11(1):55. doi: 10.1186/s12920-018-0370-x.


AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection.

Papp AC, Azad AK, Pietrzak M, Williams A, Handelman SK, Igo RP Jr, Stein CM, Hartmann K, Schlesinger LS, Sadee W.

PLoS One. 2018 May 30;13(5):e0198221. doi: 10.1371/journal.pone.0198221. eCollection 2018.


Alpha-synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3'UTR.

Barrie ES, Lee SH, Frater JT, Kataki M, Scharre DW, Sadee W.

Mol Genet Genomic Med. 2018 May 6. doi: 10.1002/mgg3.407. [Epub ahead of print]


Genetic Variants Influencing Plasma Renin Activity in Hypertensive Patients From the PEAR Study (Pharmacogenomic Evaluation of Antihypertensive Responses).

McDonough CW, Magvanjav O, Sá ACC, El Rouby NM, Dave C, Deitchman AN, Kawaguchi-Suzuki M, Mei W, Shen Y, Singh RSP, Solayman M, Bailey KR, Boerwinkle E, Chapman AB, Gums JG, Webb A, Scherer SE, Sadee W, Turner ST, Cooper-DeHoff RM, Gong Y, Johnson JA.

Circ Genom Precis Med. 2018 Apr;11(4):e001854. doi: 10.1161/CIRCGEN.117.001854.


Whole Transcriptome Sequencing Analyses Reveal Molecular Markers of Blood Pressure Response to Thiazide Diuretics.

Sá ACC, Webb A, Gong Y, McDonough CW, Datta S, Langaee TY, Turner ST, Beitelshees AL, Chapman AB, Boerwinkle E, Gums JG, Scherer SE, Cooper-DeHoff RM, Sadee W, Johnson JA.

Sci Rep. 2017 Nov 22;7(1):16068. doi: 10.1038/s41598-017-16343-z.


Elemental Ingredients in the Macrophage Cocktail: Role of ZIP8 in Host Response to Mycobacterium tuberculosis.

Pyle CJ, Azad AK, Papp AC, Sadee W, Knoell DL, Schlesinger LS.

Int J Mol Sci. 2017 Nov 9;18(11). pii: E2375. doi: 10.3390/ijms18112375. Review.


Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile.

Lavalett L, Rodriguez H, Ortega H, Sadee W, Schlesinger LS, Barrera LF.

Tuberculosis (Edinb). 2017 Dec;107:156-167. doi: 10.1016/ Epub 2017 Sep 18.


Whole Transcriptome Profiling: An RNA-Seq Primer and Implications for Pharmacogenomics Research.

Sá ACC, Sadee W, Johnson JA.

Clin Transl Sci. 2018 Mar;11(2):153-161. doi: 10.1111/cts.12511. Epub 2017 Oct 23. No abstract available.


Intronic SNP in ESR1 encoding human estrogen receptor alpha is associated with brain ESR1 mRNA isoform expression and behavioral traits.

Pinsonneault JK, Frater JT, Kompa B, Mascarenhas R, Wang D, Sadee W.

PLoS One. 2017 Jun 15;12(6):e0179020. doi: 10.1371/journal.pone.0179020. eCollection 2017.


A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.

Crouser ED, White P, Caceres EG, Julian MW, Papp AC, Locke LW, Sadee W, Schlesinger LS.

Am J Respir Cell Mol Biol. 2017 Oct;57(4):487-498. doi: 10.1165/rcmb.2016-0321OC.


Personalized Therapeutics and Pharmacogenomics: Integral to Personalized Health Care.

Sadee W.

Pharm Res. 2017 Aug;34(8):1535-1538. doi: 10.1007/s11095-017-2170-y. Epub 2017 May 10. No abstract available.


Expression and splicing of ABC and SLC transporters in the human blood-brain barrier measured with RNAseq.

Suhy AM, Webb A, Papp AC, Geier EG, Sadee W.

Eur J Pharm Sci. 2017 May 30;103:47-51. doi: 10.1016/j.ejps.2017.02.010. Epub 2017 Feb 7.


CYP2D6 Genetic Variation and Beta-Blocker Maintenance Dose in Patients with Heart Failure.

Luzum JA, Sweet KM, Binkley PF, Schmidlen TJ, Jarvis JP, Christman MF, Sadee W, Kitzmiller JP.

Pharm Res. 2017 Aug;34(8):1615-1625. doi: 10.1007/s11095-017-2104-8. Epub 2017 Feb 8.


Regulatory Variants Modulate Protein Kinase C α (PRKCA) Gene Expression in Human Heart.

Li L, Zhang L, Binkley PF, Sadee W, Wang D.

Pharm Res. 2017 Aug;34(8):1648-1657. doi: 10.1007/s11095-017-2102-x. Epub 2017 Jan 24.


Genome-Wide Prioritization and Transcriptomics Reveal Novel Signatures Associated With Thiazide Diuretics Blood Pressure Response.

Shahin MH, Sá AC, Webb A, Gong Y, Langaee T, McDonough CW, Riva A, Beitleshees AL, Chapman AB, Gums JG, Turner ST, Boerwinkle E, Scherer SE, Sadee W, Cooper-DeHoff RM, Johnson JA.

Circ Cardiovasc Genet. 2017 Jan;10(1). pii: e001404. doi: 10.1161/CIRCGENETICS.116.001404.

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