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Page 1
Design of an in vitro biocatalytic cascade for the manufacture of islatravir.
Huffman MA, Fryszkowska A, Alvizo O, Borra-Garske M, Campos KR, Canada KA, Devine PN, Duan D, Forstater JH, Grosser ST, Halsey HM, Hughes GJ, Jo J, Joyce LA, Kolev JN, Liang J, Maloney KM, Mann BF, Marshall NM, McLaughlin M, Moore JC, Murphy GS, Nawrat CC, Nazor J, Novick S, Patel NR, Rodriguez-Granillo A, Robaire SA, Sherer EC, Truppo MD, Whittaker AM, Verma D, Xiao L, Xu Y, Yang H. Huffman MA, et al. Among authors: whittaker am. Science. 2019 Dec 6;366(6470):1255-1259. doi: 10.1126/science.aay8484. Science. 2019. PMID: 31806816
Nine-Step Stereoselective Synthesis of Islatravir from Deoxyribose.
Nawrat CC, Whittaker AM, Huffman MA, McLaughlin M, Cohen RD, Andreani T, Ding B, Li H, Weisel M, Tschaen DM. Nawrat CC, et al. Among authors: whittaker am. Org Lett. 2020 Mar 20;22(6):2167-2172. doi: 10.1021/acs.orglett.0c00239. Epub 2020 Feb 28. Org Lett. 2020. PMID: 32108487
Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone.
Patel NR, Nawrat CC, McLaughlin M, Xu Y, Huffman MA, Yang H, Li H, Whittaker AM, Andreani T, Lévesque F, Fryszkowska A, Brunskill A, Tschaen DM, Maloney KM. Patel NR, et al. Among authors: whittaker am. Org Lett. 2020 Jun 19;22(12):4659-4664. doi: 10.1021/acs.orglett.0c01431. Epub 2020 Jun 9. Org Lett. 2020. PMID: 32516536
18 results