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Items: 1 to 20 of 58


Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5.

Chau Y, Li FS, Levsh O, Weng JK.

PLoS One. 2019 Sep 20;14(9):e0222803. doi: 10.1371/journal.pone.0222803. eCollection 2019.


Independent evolution of rosmarinic acid biosynthesis in two sister families under the Lamiids clade of flowering plants.

Levsh O, Pluskal T, Carballo V, Mitchell AJ, Weng JK.

J Biol Chem. 2019 Oct 18;294(42):15193-15205. doi: 10.1074/jbc.RA119.010454. Epub 2019 Sep 3.


MiR-421 inhibition protects H9c2 cells against hypoxia/reoxygenation-induced oxidative stress and apoptosis by targeting Sirt3.

Liu Y, Qian XM, He QC, Weng JK.

Perfusion. 2019 Aug 30:267659119870725. doi: 10.1177/0267659119870725. [Epub ahead of print]


The biosynthetic origin of psychoactive kavalactones in kava.

Pluskal T, Torrens-Spence MP, Fallon TR, De Abreu A, Shi CH, Weng JK.

Nat Plants. 2019 Aug;5(8):867-878. doi: 10.1038/s41477-019-0474-0. Epub 2019 Jul 22.


Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants.

Christ B, Xu C, Xu M, Li FS, Wada N, Mitchell AJ, Han XL, Wen ML, Fujita M, Weng JK.

Nat Commun. 2019 Jul 19;10(1):3206. doi: 10.1038/s41467-019-11286-7.


Production of nonnatural straight-chain amino acid 6-aminocaproate via an artificial iterative carbon-chain-extension cycle.

Cheng J, Hu G, Xu Y, Torrens-Spence MP, Zhou X, Wang D, Weng JK, Wang Q.

Metab Eng. 2019 Sep;55:23-32. doi: 10.1016/j.ymben.2019.06.009. Epub 2019 Jun 18.


The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis.

Zhao Q, Yang J, Cui MY, Liu J, Fang Y, Yan M, Qiu W, Shang H, Xu Z, Yidiresi R, Weng JK, Pluskal T, Vigouroux M, Steuernagel B, Wei Y, Yang L, Hu Y, Chen XY, Martin C.

Mol Plant. 2019 Jul 1;12(7):935-950. doi: 10.1016/j.molp.2019.04.002. Epub 2019 Apr 15.


PRX9 and PRX40 Are Extensin Peroxidases Essential for Maintaining Tapetum and Microspore Cell Wall Integrity during Arabidopsis Anther Development.

Jacobowitz JR, Doyle WC, Weng JK.

Plant Cell. 2019 Apr;31(4):848-861. doi: 10.1105/tpc.18.00907. Epub 2019 Mar 18.


Unleashing the Synthetic Power of Plant Oxygenases: From Mechanism to Application.

Mitchell AJ, Weng JK.

Plant Physiol. 2019 Mar;179(3):813-829. doi: 10.1104/pp.18.01223. Epub 2019 Jan 22. Review. No abstract available.


The molecular structure of plant sporopollenin.

Li FS, Phyo P, Jacobowitz J, Hong M, Weng JK.

Nat Plants. 2019 Jan;5(1):41-46. doi: 10.1038/s41477-018-0330-7. Epub 2018 Dec 17.


Monoamine Biosynthesis via a Noncanonical Calcium-Activatable Aromatic Amino Acid Decarboxylase in Psilocybin Mushroom.

Torrens-Spence MP, Liu CT, Pluskal T, Chung YK, Weng JK.

ACS Chem Biol. 2018 Dec 21;13(12):3343-3353. doi: 10.1021/acschembio.8b00821. Epub 2018 Dec 10.


Harnessing lignin evolution for biotechnological applications.

Renault H, Werck-Reichhart D, Weng JK.

Curr Opin Biotechnol. 2019 Apr;56:105-111. doi: 10.1016/j.copbio.2018.10.011. Epub 2018 Nov 13. Review.


Gene-guided discovery and engineering of branched cyclic peptides in plants.

Kersten RD, Weng JK.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10961-E10969. doi: 10.1073/pnas.1813993115. Epub 2018 Oct 29.


Structural and dynamic basis of substrate permissiveness in hydroxycinnamoyltransferase (HCT).

Chiang YC, Levsh O, Lam CK, Weng JK, Wang Y.

PLoS Comput Biol. 2018 Oct 26;14(10):e1006511. doi: 10.1371/journal.pcbi.1006511. eCollection 2018 Oct.


Contribution of Untargeted Metabolomics for Future Assessment of Biotech Crops.

Christ B, Pluskal T, Aubry S, Weng JK.

Trends Plant Sci. 2018 Dec;23(12):1047-1056. doi: 10.1016/j.tplants.2018.09.011. Epub 2018 Oct 22. Review.


Firefly genomes illuminate parallel origins of bioluminescence in beetles.

Fallon TR, Lower SE, Chang CH, Bessho-Uehara M, Martin GJ, Bewick AJ, Behringer M, Debat HJ, Wong I, Day JC, Suvorov A, Silva CJ, Stanger-Hall KF, Hall DW, Schmitz RJ, Nelson DR, Lewis SM, Shigenobu S, Bybee SM, Larracuente AM, Oba Y, Weng JK.

Elife. 2018 Oct 16;7. pii: e36495. doi: 10.7554/eLife.36495.


Mechanistic basis for the evolution of chalcone synthase catalytic cysteine reactivity in land plants.

Liou G, Chiang YC, Wang Y, Weng JK.

J Biol Chem. 2018 Nov 30;293(48):18601-18612. doi: 10.1074/jbc.RA118.005695. Epub 2018 Oct 5.


Pièce de Self-Résistance: a New Paradigm for Natural-Product Herbicide Discovery.

Hill M, Weng JK.

Mol Plant. 2018 Sep 10;11(9):1115-1116. doi: 10.1016/j.molp.2018.08.002. Epub 2018 Aug 15. Review. No abstract available.


Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis.

Ban Z, Qin H, Mitchell AJ, Liu B, Zhang F, Weng JK, Dixon RA, Wang G.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5223-E5232. doi: 10.1073/pnas.1802223115. Epub 2018 May 14.


Crystalline-Sponge-Based Structural Analysis of Crude Natural Product Extracts.

Wada N, Kersten RD, Iwai T, Lee S, Sakurai F, Kikuchi T, Fujita D, Fujita M, Weng JK.

Angew Chem Int Ed Engl. 2018 Mar 26;57(14):3671-3675. doi: 10.1002/anie.201713219. Epub 2018 Mar 5.


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