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Items: 1 to 20 of 26

1.

Single injection of PTH improves osteoclastic parameters of remodeling at a stress fracture site in rats.

Bakr MM, Kelly WL, Brunt AR, Paterson BC, Massa HM, Morrison NA, Forwood MR.

J Orthop Res. 2019 Feb 28. doi: 10.1002/jor.24262. [Epub ahead of print]

PMID:
30816593
2.

Biosynthesis of the Thiopeptins and Identification of an F420H2-Dependent Dehydropiperidine Reductase.

Ichikawa H, Bashiri G, Kelly WL.

J Am Chem Soc. 2018 Aug 29;140(34):10749-10756. doi: 10.1021/jacs.8b04238. Epub 2018 Aug 17.

PMID:
30118217
3.

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12432-12437. Epub 2016 Oct 17.

4.

Spectroscopic and Electrochemical Characterization of the Iron-Sulfur and Cobalamin Cofactors of TsrM, an Unusual Radical S-Adenosylmethionine Methylase.

Blaszczyk AJ, Silakov A, Zhang B, Maiocco SJ, Lanz ND, Kelly WL, Elliott SJ, Krebs C, Booker SJ.

J Am Chem Soc. 2016 Mar 16;138(10):3416-26. doi: 10.1021/jacs.5b12592. Epub 2016 Mar 3.

PMID:
26841310
5.

Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue.

Zhang F, Li C, Kelly WL.

ACS Chem Biol. 2016 Feb 19;11(2):415-24. doi: 10.1021/acschembio.5b00731. Epub 2015 Dec 14.

6.

Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.

Zhang F, Kelly WL.

ACS Chem Biol. 2015 Apr 17;10(4):998-1009. doi: 10.1021/cb5007745. Epub 2015 Jan 20.

7.

Osteocyte expression of caspase-3, COX-2, IL-6 and sclerostin are spatially and temporally associated following stress fracture initiation.

Wu AC, Kidd LJ, Cowling NR, Kelly WL, Forwood MR.

Bonekey Rep. 2014 Sep 3;3:571. doi: 10.1038/bonekey.2014.66. eCollection 2014.

8.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

9.

In vivo production of thiopeptide variants.

Zhang F, Kelly WL.

Methods Enzymol. 2012;516:3-24. doi: 10.1016/B978-0-12-394291-3.00022-8.

PMID:
23034221
10.

Selective and non-selective cyclooxygenase inhibitors delay stress fracture healing in the rat ulna.

Kidd LJ, Cowling NR, Wu AC, Kelly WL, Forwood MR.

J Orthop Res. 2013 Feb;31(2):235-42. doi: 10.1002/jor.22203. Epub 2012 Jul 30.

11.

Biosynthesis: Ringing in a new view.

Kelly WL.

Nat Chem Biol. 2012 May 17;8(6):505-7. doi: 10.1038/nchembio.973. No abstract available.

PMID:
22596200
12.

Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function.

Li C, Zhang F, Kelly WL.

Chem Commun (Camb). 2012 Jan 14;48(4):558-60. doi: 10.1039/c1cc14281j. Epub 2011 Nov 8.

13.

Biochemistry: life imitates art.

Kelly WL.

Nature. 2011 May 5;473(7345):35-6. doi: 10.1038/473035a. No abstract available.

PMID:
21544137
14.

Identification of a tetraene-containing product of the indanomycin biosynthetic pathway.

Rommel KR, Li C, Kelly WL.

Org Lett. 2011 May 20;13(10):2536-9. doi: 10.1021/ol200570u. Epub 2011 Apr 14.

PMID:
21491871
15.

Heterologous production of thiostrepton A and biosynthetic engineering of thiostrepton analogs.

Li C, Zhang F, Kelly WL.

Mol Biosyst. 2011 Jan;7(1):82-90. doi: 10.1039/c0mb00129e. Epub 2010 Nov 25.

PMID:
21107477
16.

Recent advances in thiopeptide antibiotic biosynthesis.

Li C, Kelly WL.

Nat Prod Rep. 2010 Feb;27(2):153-64. doi: 10.1039/b922434c. Epub 2009 Dec 7. Review.

PMID:
20111801
17.

Analysis of the indanomycin biosynthetic gene cluster from Streptomyces antibioticus NRRL 8167.

Li C, Roege KE, Kelly WL.

Chembiochem. 2009 Apr 17;10(6):1064-72. doi: 10.1002/cbic.200800822.

PMID:
19301315
18.

Thiostrepton biosynthesis: prototype for a new family of bacteriocins.

Kelly WL, Pan L, Li C.

J Am Chem Soc. 2009 Apr 1;131(12):4327-34. doi: 10.1021/ja807890a.

PMID:
19265401
19.

Biosynthetic origins of the ionophore antibiotic indanomycin.

Roege KE, Kelly WL.

Org Lett. 2009 Jan 15;11(2):297-300. doi: 10.1021/ol802422n.

PMID:
19072095
20.

Intramolecular cyclizations of polyketide biosynthesis: mining for a "Diels-Alderase"?

Kelly WL.

Org Biomol Chem. 2008 Dec 21;6(24):4483-93. doi: 10.1039/b814552k. Epub 2008 Nov 4. Review.

PMID:
19039353

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