Transethnic genome-wide scan identifies novel Alzheimer's disease loci

Affiliations

• ¹ Neurogenetics and Integrated Genomics, Andover Innovative Medicines Institute, Eisai Inc, Andover, MA, USA; Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA.
• ² Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA.
• ³ Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA.
• ⁴ Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
• ⁵ The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
• ⁶ Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA.
• ⁷ Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA; Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY, USA.
• ⁸ Department of Biology, North Carolina A&T State University, Greensboro, NC, USA.
• ⁹ Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
• ¹⁰ Department of Medicine, University of Washington, Seattle, WA, USA.
• ¹¹ Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St Louis, MO, USA; Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
• ¹² Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology & Psychiatry, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
• ¹³ Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA.
• ¹⁴ Department of Mental Health, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
• ¹⁵ Department of Medical & Molecular Genetics, Indiana University, Indianapolis, IN, USA.
• ¹⁶ Department of Neurology, University of Louisville, Louisville, KY, USA.
• ¹⁷ Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA.
• ¹⁸ Department of Psychiatry, Indiana University, Indianapolis, IN, USA; Regenstrief Institute, Inc, Indianapolis, IN, USA.
• ¹⁹ Regenstrief Institute, Inc, Indianapolis, IN, USA; Department of Medicine, Indiana University, Indianapolis, IN, USA.
• ²⁰ Department of Neurology and Neurosurgery, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
• ²¹ University of Pittsburgh Alzheimer's Disease Research Center and Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
• ²² Department of Biology, Brigham Young University, Provo, UT, USA.
• ²³ Department of Epidemiology, University of Washington, Seattle, WA, USA; National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA.
• ²⁴ Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
• ²⁵ Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA; Group Health, Group Health Research Institute, Seattle, WA, USA.
• ²⁶ Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurological Sciences and Rush Alzheimer's Disease Center, Chicago, IL, USA; National Center for PTSD, Behavioral Science Division, Boston VA Healthcare System, Boston, MA, USA.
• ²⁷ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
• ²⁸ Department of Pathology, Stanford University, Stanford, CA, USA.
• ²⁹ Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
• ³⁰ Arizona Alzheimer's Consortium, Phoenix, AZ, USA; Department of Psychiatry, University of Arizona, Phoenix, AZ, USA; Banner Alzheimer's Institute, Phoenix, AZ, USA; Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.
• ³¹ The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
• ³² Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Canada; Cambridge Institute for Medical Research and Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
• ³³ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
• ³⁴ Arizona Alzheimer's Consortium, Phoenix, AZ, USA.
• ³⁵ PharmaTherapeutics Clinical Research, Pfizer Worldwide Research and Development, Cambridge, MA, USA.
• ³⁶ Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA.
• ³⁷ The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Department of Epidemiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
• ³⁸ Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA.
• ³⁹ Department of Medicine (Biomedical Genetics), Boston University Schools of Medicine, Boston, MA, USA; Department of Neurology, Boston University Schools of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University Schools of Public Health, Boston, MA, USA; Department of Ophthalmology, Boston University Schools of Medicine, Boston, MA, USA; Department of Epidemiology, Boston University Schools of Public Health, Boston, MA, USA. Electronic address: farrer@bu.edu.