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Transpl Int. 2017 Jan;30(1):68-75. doi: 10.1111/tri.12874. Epub 2016 Nov 2.

Balancing competing needs in kidney transplantation: does an allocation system prioritizing children affect the renal transplant function?

Author information

1
University Children's Hospital Zurich, Zurich, Switzerland.
2
Children's Hospital, Lucerne, Switzerland.
3
Institute for Social and Preventive Medicine, Berne, Switzerland.
4
University Children's Hospital, Geneva, Switzerland.
5
University Children's Hospital, Lausanne, Switzerland.
6
University Children's Hospital, Berne, Switzerland.
7
Swisstransplant, Berne, Switzerland.

Abstract

Children often merit priority in access to deceased donor kidneys by organ-sharing organizations. We report the impact of the new Swiss Organ Allocation System (SOAS) introduced in 2007, offering all kidney allografts from deceased donors <60 years preferentially to children. The retrospective cohort study included all paediatric transplant patients (<20 years of age) before (n = 19) and after (n = 32) the new SOAS (from 2001 to 2014). Estimated glomerular filtration rate (eGFR), urine protein-to-creatinine ratio (UPC), need for antihypertensive medication, waiting times to kidney transplantation (KTX), number of pre-emptive transplantations and rejections, and the proportion of living donor transplants were considered as outcome parameters. Patients after the new SOAS had significantly better eGFRs 2 years after KTX (Mean Difference, MD = 25.7 ml/min/1.73 m2 , P = 0.025), lower UPC ratios (Median Difference, MeD = -14.5 g/mol, P = 0.004), decreased waiting times to KTX (MeD = -97 days, P = 0.021) and a higher proportion of pre-emptive transplantations (Odds Ratio = 9.4, 95% CI = 1.1-80.3, P = 0.018), while the need for antihypertensive medication, number of rejections and living donor transplantations remained stable. The new SOAS is associated with improved short-term clinical outcomes and more rapid access to KTX. Despite lacking long-term research, the study results should encourage other policy makers to adopt the SOAS approach.

KEYWORDS:

children; kidney allocation; kidney transplant function; policy analysis

PMID:
27732754
DOI:
10.1111/tri.12874
[Indexed for MEDLINE]
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