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Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.
J Am Chem Soc. 2006 Apr 26;128(16):5310-1. doi: 10.1021/ja058636j.
J Am Chem Soc. 2006.
PMID: 16620080
Free PMC article.
Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J.
Ghosh AK, et al. Among authors: weerasena v.
J Med Chem. 2007 May 17;50(10):2399-407. doi: 10.1021/jm061338s. Epub 2007 Apr 14.
J Med Chem. 2007.
PMID: 17432843
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Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation.
Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J.
Ghosh AK, et al. Among authors: weerasena v.
Bioorg Med Chem Lett. 2008 Feb 1;18(3):1031-6. doi: 10.1016/j.bmcl.2007.12.028. Epub 2008 Jan 3.
Bioorg Med Chem Lett. 2008.
PMID: 18180160
Free PMC article.
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In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.
Chang WP, Koelsch G, Wong S, Downs D, Da H, Weerasena V, Gordon B, Devasamudram T, Bilcer G, Ghosh AK, Tang J.
Chang WP, et al. Among authors: weerasena v.
J Neurochem. 2004 Jun;89(6):1409-16. doi: 10.1111/j.1471-4159.2004.02452.x.
J Neurochem. 2004.
PMID: 15189343
Free article.
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Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J.
Ghosh AK, et al. Among authors: weerasena v.
Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. doi: 10.1016/j.bmcl.2004.10.084.
Bioorg Med Chem Lett. 2005.
PMID: 15582402
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