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World J Clin Oncol. 2018 Dec 20;9(8):180-187. doi: 10.5306/wjco.v9.i8.180.

Role of senescence induction in cancer treatment.

Author information

1
Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, United States.

Abstract

Cellular senescence is a form of permanent cell cycle arrest that can be triggered by a variety of cell-intrinsic and extrinsic stimuli, including telomere shortening, DNA damage, oxidative stress, and exposure to chemotherapeutic agents and ionizing radiation. Although the induction of apoptotic cell death is a desirable outcome in cancer therapy, mutations and/or deficiencies in the apoptotic signaling pathways have been frequently identified in many human cancer types, suggesting the importance of alternative apoptosis-independent therapeutic approaches for cancer treatment. A growing body of evidence has documented that senescence induction in tumor cells is a frequent response to many anticancer modalities including cyclin-dependent kinases 4/6 small molecule inhibitor-based targeted therapeutics and T helper-1 cytokine-mediated immunotherapy. This review discusses the recent advances and clinical relevance of therapy-induced senescence in cancer treatment.

KEYWORDS:

Aurora kinase inhibitor; Cancer treatment; Cellular senescence; Chemotherapy; Cyclin-dependent kinases 4/6 inhibitor; Immunotherapy; Ionizing radiation; T helper-1 cells; T helper-1 cytokines

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