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Items: 1 to 20 of 47

1.

Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group.

Berger M, Schenning KJ, Brown CH 4th, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z; Perioperative Neurotoxicity Working Group.

Anesth Analg. 2018 Oct 9. doi: 10.1213/ANE.0000000000003841. [Epub ahead of print]

PMID:
30303868
2.

Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia.

Wang DS, Kaneshwaran K, Lei G, Mostafa F, Wang J, Lecker I, Avramescu S, Xie YF, Chan NK, Fernandez-Escobar A, Woo J, Chan D, Ramsey AJ, Sivak JM, Lee CJ, Bonin RP, Orser BA.

Anesthesiology. 2018 Sep;129(3):477-489. doi: 10.1097/ALN.0000000000002311.

PMID:
29889105
3.

Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.

Wang DS, Mazer CD, Orser BA.

N Engl J Med. 2017 May 11;376(19):1891-2. doi: 10.1056/NEJMc1703369. No abstract available.

PMID:
28492070
4.

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors.

Lecker I, Wang DS, Kaneshwaran K, Mazer CD, Orser BA.

Anesthesiology. 2017 Jul;127(1):89-97. doi: 10.1097/ALN.0000000000001665.

PMID:
28475556
5.

Preventing delirium: beyond dexmedetomidine.

Avramescu S, Wang DS, Choi S, Orser BA.

Lancet. 2017 Mar 11;389(10073):1009. doi: 10.1016/S0140-6736(17)30661-X. No abstract available.

PMID:
28290991
6.

Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons.

Wang DS, Penna A, Orser BA.

Anesthesiology. 2017 Apr;126(4):666-677. doi: 10.1097/ALN.0000000000001483.

PMID:
27984263
7.

δGABAA Receptors Are Necessary for Synaptic Plasticity in the Hippocampus: Implications for Memory Behavior.

Whissell PD, Avramescu S, Wang DS, Orser BA.

Anesth Analg. 2016 Nov;123(5):1247-1252.

PMID:
27464975
8.

In Reply.

Avramescu S, Wang DS, Horner RL, Orser BA.

Anesthesiology. 2016 Sep;125(3):604-5. doi: 10.1097/ALN.0000000000001206. No abstract available.

PMID:
27529857
9.

Tranexamic acid-associated seizures: Causes and treatment.

Lecker I, Wang DS, Whissell PD, Avramescu S, Mazer CD, Orser BA.

Ann Neurol. 2016 Jan;79(1):18-26. doi: 10.1002/ana.24558. Epub 2015 Dec 15. Review.

10.

Inflammation Increases Neuronal Sensitivity to General Anesthetics.

Avramescu S, Wang DS, Lecker I, To WT, Penna A, Whissell PD, Mesbah-Oskui L, Horner RL, Orser BA.

Anesthesiology. 2016 Feb;124(2):417-27. doi: 10.1097/ALN.0000000000000943.

PMID:
26566283
11.

Sustained increase in α5GABAA receptor function impairs memory after anesthesia.

Zurek AA, Yu J, Wang DS, Haffey SC, Bridgwater EM, Penna A, Lecker I, Lei G, Chang T, Salter EW, Orser BA.

J Clin Invest. 2014 Dec;124(12):5437-41. doi: 10.1172/JCI76669. Epub 2014 Nov 3.

12.

Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure.

Zhou M, Luo P, Lu Y, Li CJ, Wang DS, Lu Q, Xu XL, He Z, Guo LJ.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:207-14. doi: 10.1016/j.pnpbp.2014.09.010. Epub 2014 Oct 7.

PMID:
25301101
13.

Altered expression of δGABAA receptors in health and disease.

Whissell PD, Lecker I, Wang DS, Yu J, Orser BA.

Neuropharmacology. 2015 Jan;88:24-35. doi: 10.1016/j.neuropharm.2014.08.003. Epub 2014 Aug 13. Review.

PMID:
25128850
14.

Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons.

Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA.

J Neurosci. 2014 Aug 6;34(32):10624-34. doi: 10.1523/JNEUROSCI.0335-14.2014.

15.

Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus.

Whissell PD, Eng D, Lecker I, Martin LJ, Wang DS, Orser BA.

Front Neural Circuits. 2013 Sep 17;7:146. doi: 10.3389/fncir.2013.00146. eCollection 2013.

16.

γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus.

Whissell PD, Rosenzweig S, Lecker I, Wang DS, Wojtowicz JM, Orser BA.

Ann Neurol. 2013 Oct;74(4):611-21. doi: 10.1002/ana.23941. Epub 2013 Jul 8.

PMID:
23686887
17.

Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists.

Lecker I, Yin Y, Wang DS, Orser BA.

Br J Anaesth. 2013 Jun;110 Suppl 1:i73-81. doi: 10.1093/bja/aet038. Epub 2013 Mar 27.

18.

Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.

Lecker I, Wang DS, Romaschin AD, Peterson M, Mazer CD, Orser BA.

J Clin Invest. 2012 Dec;122(12):4654-66. doi: 10.1172/JCI63375. Epub 2012 Nov 26.

19.

Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors.

Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA.

Cell Rep. 2012 Sep 27;2(3):488-96. doi: 10.1016/j.celrep.2012.08.022. Epub 2012 Sep 20.

20.

Role of acid-sensing ion channel 1a in the secondary damage of traumatic spinal cord injury.

Hu R, Duan B, Wang D, Yu Y, Li W, Luo H, Lu P, Lin J, Zhu G, Wan Q, Feng H.

Ann Surg. 2011 Aug;254(2):353-62. doi: 10.1097/SLA.0b013e31822645b4.

PMID:
21725232

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